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Paediatric pelvic physiotherapy added to conventional treatment of functional constipation in children in primary care.

The primary objective is to study the effect of paediatric pelvic physiotherapy in addition to conventional therapy on the number of patients with treatment success in children aged 4-17 years presenting in primary care with functional constipation…

Effect of domperidone and omeprazole in gastro-oesophageal reflux disease in infants between 0 and 2 years.

To measure the effect of domperidone and omeprazole on reflux-time, duration, and symptoms of GERD

A Multicenter Randomized Parallel Group Phase III Study Comparing the Bowel Cleansing Efficacy, Safety and Tolerability of NER1006 (a Low Volume Bowel Cleansing Solution) versus a Sodium Picosulfate and Magnesium Salt (SP+MS) Solution Using a Day Before-Only Dosing Regimen in Adults

Primary Objectives: To evaluate the overall bowel cleansing efficacy and the *Excellent plus Good* cleansing rate in the colon ascendens of a 1-day day before-only split-dosing regimen with NER1006 compared to a 1-day day before-only split-dosing…

Hypnotherapy through self-exercises in children with functional abdominal pain
in primary care

To determine the (cost)-effectiveness of home-based hypnotherapy by self-exercises added to usual care (UC) of general practitioners (GPs) compared with UC of GPs alone in children with FAP or IBS.

HELIOS-A: A Phase 3 Global, Randomized, Open-label Study to Evaluate the Efficacy and Safety of ALN-TTRSC02 in Patients with Hereditary Transthyretin Amyloidosis (hATTR Amyloidosis)

This study has been transitioned to CTIS with ID 2023-508365-33-00 check the CTIS register for the current data. To determine the efficacy of ALNTTRSC02 in patients with hATTR amyloidosis by evaluating the effect on neurologic impairment. To…

Toddlers receiving synbiotics after antibiotics

To investigate the effect of a cows-milk-based formula supplemented with synbiotics from t=0 to t=21, t=42 and t=84 days after amoxicillin or amoxicillin/clavulanic acid treatment in toddlers aged 1, 2 and 3 years old on: - change in proportion of…

Face-to-face versus online hypnotherapy for the treatment of Irritable Bowel Syndrome, according to a non-inferiority design. Three-armed randomized controlled trial. (FORTITUDE)

Primary objective:To compare the efficacy of online hypnotherapy versus face-to-face according to a non-inferiority design for the treatment of IBS.Hypothesis: Hypnotherapy delivered in the form of online exercises has non-inferior efficacy to face-…