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Treatment of Fatigue in Multiple Sclerosis: Aerobic Training, Cognitive Behavioural Therapy, Energy Conservation Management

To determine whether rehabilitation treatment strategies effectively reduce fatigue and improve participation in MS patients with fatigue, and how they exert their effects.Research questionsQ1) Does AT result in reduced fatigue and improved…

A Multicenter, Randomized, Rater-Blind, Parallel-Group, Active Controlled Study to Evaluate the Benefits of Switching Therapy (Glatiramer Acetate or Interferon β-1a) to Natalizumab in Subjects with Relapsing Remitting Multiple Sclerosis

The primary objective of this study is to evaluate the efficacy (clinical and MRI) of switching tonatalizumab compared to receiving interferon β1-a or glatiramer acetate.

A Phase 3 Randomized, Rater- and Dose-Blinded Study Comparing Two Annual Cycles of Intravenous Low- and High-Dose Alemtuzumab to Three-Times Weekly Subcutaneous Interferon Beta-1a (Rebif®) in Patients with Relapsing-Remitting Multiple Scleroris Who Have Relapsed On Therapy

The objectives of this study are to compare the safety and efficacy of 2 annual cycles of intravenous (IV) alemtuzumab to 3-times weekly subcutaneous (SC) interferon beta 1a (Rebif*) in patients with active relapsing-remitting multiple sclerosis (…

Supplementation of Vigantol oil versus placebo as Add-on in patients with relapsing remitting multiple sclerosis receiving Rebif treatment (immune modulating effects of vitamin D3)

The primary objective of this study is to assess whether the CD4+ T cell compartment displays a less pro-inflammatory profile in patients which are supplemented for the SOLAR study with high doses of vitamin D3 when compared to patients which are…

Efficacy of client-centred occupational therapy in patients with multiple sclerosis: a cluster-randomized trial

The main research question of this study is:Is client-centred occupational therapy according to the Occupational Performance Process Model more effective than usual-care occuaptional therapy in patients with multiple sclerosis?

High-field magnetic resonance imaging in multiple sclerosis

The objective of this study is the visualisation of diffuse and focal lesion in the brain in Multiple Sclerosis on higher main magnetic fields. Images from 1.5 Tesla MR scanners will be compared with images acquired at 3 Tesla and images made on 3…

Randomized Autologous heMatopoietic stem cell transplantation versus alemtuzumab, cladribine or ocrelizumab for patients with relapsing remitting Multiple Sclerosis

This study has been transitioned to CTIS with ID 2024-510630-40-00 check the CTIS register for the current data. The objective of this prospective, randomized study is to investigate the efficacy and safety of HSCT compared to the comparator group (…

Blended versus face-to-face Cognitive Behavioural Therapy in treating severe fatigue in patients with MS - an observer-blinded randomized clinical trial testing non-inferiority at post-treatment and long-term effectiveness.

1. To investigate the non-inferiority of blended CBT compared to proven effective face-to-face CBT according to the TREFAMS-CBT treatment protocol in severely fatigued patients with MS, using a non-inferiority margin of 5.3 points on the Checklist…

Efficacy, safety and cost-effectiveness of B cell tailored ocrelizumab versus standard ocrelizumab in relapsing remitting multiple sclerosis: a randomized controlled trial

With this study we aim to prove that personalized B cell tailored ocrelizumab treatment is non-inferior in the suppression of MS disease activity (clinically and radiologically) compared to the standard (fixed 24 week interval) treatment.

Postponing cognitive decline and preventing early unemployment in patients with multiple sclerosis - strengthening the brain and mind (part of the Don't be late! study)

(1) To compare the efficacy of two innovative preventative interventions with a control intervention in improving quality of life, cognition, work participation and productivity, brain plasticity and resilience, (2) to gain insight into the…

A PHASE III MULTICENTER, RANDOMIZED, DOUBLE-BLIND, DOUBLE-DUMMY, PARALLEL-GROUP STUDY TO EVALUATE THE EFFICACY AND SAFETY OF FENEBRUTINIB COMPARED WITH TERIFLUNOMIDE IN ADULT PATIENTS WITH RELAPSING MULTIPLE SCLEROSIS

The goal of the fenebrutinib development program in MS is to evaluate the benefits and risks of fenebrutinib treatment across the spectrum of patients with MS. Based on the existing toxicology, pharmacology, and clinical experience with fenebrutinib…

A PHASE IIIB MULTICENTER, RANDOMIZED, DOUBLE-BLIND, CONTROLLED STUDY TO EVALUATE THE EFFICACY, SAFETY AND PHARMACOKINETICS OF A HIGHER DOSE OF OCRELIZUMAB IN ADULTS WITH RELAPSING MULTIPLE SCLEROSIS

This study will evaluate the efficacy, safety, and pharmacokinetics of a higher dose of ocrelizumab compared with the approved dose of ocrelizumab in patients with relapsing forms of multiple sclerosis.

The effect of cognitive rehabilitation therapy and mindfulness based cognitive therapy on cognitive functioning in multiple sclerosis.

The main aim of the current study is to investigate whether two promising therapies, namely cognitive rehabilitation therapy (CRT) and mindfulness based cognitive therapy (MBCT), may improve cognitive functioning of patients with MS. Additionally,…

Need for speed: a pilot study on feasibility of cognitive rehabilitation for patients with progressive multiple sclerosis (MS)

The aim of this pilot study is to investigate the feasibility and to gain preliminary information on the effectiveness of a cognitive rehabilitation program in patients with (severe) progressive MS, i.e. a speed of processing training (SPT).…