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Cardiovascular Riskprofile in Women: Microvascular Status

To gain further insight into the interaction and possibly shared pathophysiological mechanisms of female-specific cardiovascular risk factors and events we will quantify white matter hyperintensities on brain MRI and assess endothelial function in…

Transcendental Meditation or Hypnotherapy versus Standard Medical Care for the Treatment of Children with Primary Headaches: a Multi-Centre, Pragmatic, Randomized Clinical Study

The goal of this pragmatic, randomized controlled study is to determine the effectiveness of two relaxation techniques, eg. TM or HT added to the treatment of paediatric primary headaches in comparison to standard medical treatment (SMT). TM or HT…

Effectiveness of treatment for chronic tension headache by the general practitioner or manual therapist: pilot study for a randomized clinical trial

The objective of this pilot study is to test the feasiblity of all procedures of the RCT. The aim of the final study is to investigate the short term and long term effects of manual therapy on the frequency of headache and the use of pain medication…

GM-11: A randomized, multicentre, double-blind, parallel, sham-controlled study of the gammaCore®-R, a non-invasive neurostimulator device, for the prevention of episodic migraine

Primary objective:The primary objective is the difference between the gammaCore®-R and the sham treatment groups in mean reduction in number of episodic migraine days during the last four weeks in the twelve-week randomized period compared with the…

Effectiveness of manual therapy compared to usual care by the general practitioner for migraine: a pilot study

Objective of the pilot study is to examine whether a pragmatic randomised trial on the effectiveness of manual therapy compared to general practice care in migraine is feasible.For this purpose we use the following questions.* Is it possible to…

Open-label randomized controlled trial for the effects of continuous ethinylestradiol/levonorgestrel (30/150 µg/day) compared with vitamin E (400 IU/day) in the treatment of menstrually-related migraine and migraine during perimenopause

This study has been transitioned to CTIS with ID 2024-517127-40-00 check the CTIS register for the current data. To study the effects of continuous use of ethinylestradiol/levonorgestrel (30/150 µg/day) compared to vitamin E (400 IU/day) in the…

A 12-month prospective, randomized, interventional, global, multi-center, active-controlled study comparing sustained benefit of two treatment paradigms (erenumab qm vs. oral prophylactics) in adult episodic migraine patients

The purpose of this study is to determine the sustained benefit on safety and efficacy of AMG 334 compared to oral prophylactics in episodic migraine patients who have previously failed 1 to 2 prophylactic migraine treatments and therefore have a…

Manual therapy as a prophylactic treatment for migraine. A pragmatic RCT

The objective of our randomized controlled trial (RCT) is to assess the effectiveness of a multimodal manual therapy treatment compared to usual care for the prophylactic treatment of migraine.

The feasibility, desirability and effects of physical activity coaching and feedback on the level of physical activity of patients with migraine - a pilot study

Primary objective is firstly to test the feasibility and the desirability of an intervention including coaching sessions and a pedometer both to improve the level of physical activity of patients with migraine, secondly to explore the difference in…

Occipital nerve stimulation in medically intractable, chronic cluster headache

Primary: To demonstrate that high (100%) stimulation of ONS therapy reduces the mean attack frequency (MAF) in MICCH by at least 35% compared to low (30%) stimulation of ONS.Secondary: To evaluate • the rate of responders (>= 50% reduction in…