121 results
Aim of this study is to examine the mechanisms by which attachment style and emotion regulation relate to depressive symptoms and anxiety symptoms in a clinical and non-clinical Dutch population.
to investigate whether microbial transplantation from either allogenic (healthy) or autologous (own) donor, administered through a small intestinal tube, has beneficial effects on immune status, betacell function c-peptide secretion upon mixed meal…
Primary objective: To assess the effects of hypercaloric overfeeding in humans on vascular and metabolic insulin sensitivity and moreover, to establish whether insulin resistance develops in the vasculature before it occurs in peripheral tissue…
To gain further insight into the interaction and possibly shared pathophysiological mechanisms of female-specific cardiovascular risk factors and events we will quantify white matter hyperintensities on brain MRI and assess endothelial function in…
Primairy objective:To compare the incidence of inflammation between the test group (MIPS technique using an Oticon Medical Ponto abutment and implant) and control group ( Hultcrantz technique using an Oticon Medical Ponto abutment and implant) after…
The main objective of this study is to assess whether ICD therapy in dialysis patients reduces sudden (arrhythmogenic) cardiac death. The first secondary end point is to compare total mortality death between the two groups. An other is to evaluate…
To study the effectiveness of gut-directed hypnotherapy in the treatment of IBS-like symptoms in patients with inflammatory bowel disease.
Primary objective:- To investigate if exercise can modulate neurogenesis and angiogenesis in vivo, and whether this is associated with changes in hippocampal function, such as pattern separationSecondary objectives:- To assess whether exercise-…
Study I aims to explore dysregulation of biological stress systems among traumatized youths with and without ID in residential care, and compare them with a healthy control group. Study II aims to conduct a randomized controlled trial (RCT) to test…
Primary objective: Investigate the effects of acute stress on resting state and task-induced connectivity in the brain of healthy individuals and unaffected siblings of schizophrenia patients. Secondary objectives: - Correlate the endocrine stress…
In the proposed study, we will experimentally elucidate the effect of DBS on various critical dimensions of cognitive control including: the free will experience, instrumental learning, environmental change detection and working memory.
This study has two main objectives. One objective is to investigate which cognitive and affective mechanisms can be influenced through treatment which leads to improved social functioning. We will use a carefully selected set of behavioral,…
The primary objective of our study is to determine the efficacy and safety of top-down IFX treatment in moderate-to-severe pediatric CD.Secundary objectives are determination of PK data and predictors of response to IFX in pediatric CD.
Primary objective 1: Does repeated relevant checking in general lead to automatization in OCD patients? Primary objective 2: If automatization as a result of repeated relevant checking occurs, do OCD patients differ from other anxiety disorder…
(i) To compare the DBF response to capsaicin between cystinosis patients, homozygous and heterozygous for the 57-kb deletion, and matched controls.(ii) To compare the skin sensitivity response after capsaicin application between cystinosis patients,…
The primary objective is to study the course of muscle (fiber) atrophy in elderly males and females with a fall-related hip fracture or elective hip surgery and the influence of additional nutritional support during hospital admission. Secondary…
- To determine the effects of the pacing site on prevention of AF episodes - To examine the relation between the pacing site, reduction of AF episodes, quality of life, heart failure, number of cardioversions, frequency and duration of hospital…
To compare the digestibility, bioavailability and subsequent muscle protein synthetic response to casein, with casein protein provided in an isolated manner versus casein in a milk matrix, in healthy elderly subjects
The primary objective of the clinical part of EPISTOP project is to identify the clinical and molecular biomarkers of epileptogenesis in a prospective clinical study of patients with TSC. Secondary objective of the clinical part of EPISTOP is to…
Primary objective: - Investigate the effects of childhood maltreatment on basal and stress-induced in vivo metabolite concentrations in the brain measured with 7T-MRS. Secondary objectives: - Correlate the endocrine, autonomic and subjective stress…