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Anticoagulants for Living Fetuses in women with recurrent miscarriage and inherited thrombophilia; ALIFE2 study

To evaluate the efficacy of low molecular weight heparin (LMWH) in women with inherited thrombophilia and recurrent miscarriage on live birth.

Cyclopentolate induced EEG changes in children

To compare the EEG pattern after administration of cyclopentolate with the EEG pattern after placebo eye-drops.Primary outcomeEEG pattern changes after administration of two drops of cyclopentolate1% compared with placebo.Secondary outcomes- Pattern…

Rosacea and the subpurpuric pulsed dye laser treatment efficacy - a randomized controlled trial

Primary objectiveTo compare the efficacy of subpurpuric pulsed dye laser treatment with different intervals between treatment sessions.Secondary objectiveTo evaluate the safety and the long-term effects of subpurpuric pulsed dye laser treatment.

INDEX:Costs and effects of induction of labour versus expectant management in women with impending post-term pregnancies: the 41 week-42 week dilemma

First ObjectiveIn this study we compare a policy of labour induction at 41 weeks with a policy of expectant management until 42 weeks, with an outpatient check for CTG monitoring and ultrasound measurement in the 42nd week, with respect to the…

Effect of long biliopancreatic limb length in laparoscopic Roux-en-Y Gastric Bypass on weight loss and comorbidities in patients with morbid obesity: a prospective randomized control trial

To investigate the effect of variations in the length of bilipancreatic limb on weightreduction in morbidly obese patients undergoing RYGB-surgery.

Use of platelet rich plasma(PRP) as an adjunct in the treatment of high peri-anal fistulas.

Objective: the use of autologous platelet rich plasma (PRP) as an adjunct to the staged mucosal advancement flap to achieve a better closure rate of high peri-anal fistula*s.

The effects of a yoga-based stress reduction program on fatigue and quality of life in women with chemotherapy for breast cancer: a mono-centre, pragmatic, randomized clinical study

To investigate whether an adjunctive YBSR program added to standard care compared to standard care alone, can reduce:1.fatigue symptoms (primary objective)2.psychological distressand improve:3.health-related quality of life4.sense of coherence5.…

The WOW! Study, Weight-bearing or Non-Weight bearing. A prospective randomised multicenter comparison of three different care regimens after operatively fixed ankle fractures.

Primary Objective: Compare functional results of the three postoperative care regimens assessed with the Olerud-Molander ankle score 12 weeks after surgery.Secondary Objective(s): 1) Compare functional results and patient satisfaction of the three…

Hypnotherapy for adolescents and adults with inflammatory bowel disease and symptoms compatible with irritable bowel syndrome.

To study the effectiveness of gut-directed hypnotherapy in the treatment of IBS-like symptoms in patients with inflammatory bowel disease.

Perioperative selective decontamination of the digestive tract (SDD) in elective colorectal cancer patients: a multicenter randomized clinical trial

The primary objective of this randomized clinical trial is to evaluate if perioperative SDD can reduce anastomotic leakage rate and other infectious complications while thereby simultaneously improving long-term oncological outcome. Secondary…

Fatigue in palliative cancer care: are graded exercise and cognitive behaviour therapy effective treatments and what mediates the treatment response?

Research questions1. What are the effects of GET and CBT in severely fatigued patients receiving first line of palliative treatment for breast or colon cancer on fatigue severity compared to usual care?2. What are the mediators of the change in…

Effect of local anesthetic dose versus volume on block duration of single shot ultrasound-guided axillary brachial plexus block with mepivacaine.

Primary objective: to determine the effect of mepivacaine dose and volume on the duration of sensory axillary brachial plexus block (overall and individual nerves).Our hypothesis (H0) is that there is no difference (less than 60 min) in duration of…

Effect of a PReoperative Information Video on Anxiety in Deep Brain Stimulation surgery patients

Our aim is to investigate whether patients who are informed by video will have less preoperative anxiety than the patients who receive usual information.

A Double-Blind, Randomized, Parallel Group, Multi-Centre Study to Evaluate the Efficacy and Safety of Mirabegron Compared to Solifenacin in Subjects with Overactive Bladder (OAB) Treated with Antimuscarinics and Dissatisfied due to Lack of Efficacy

To assess the efficacy of Mirabegron 50mg versus Solifenacin 5mg in the treatment of subjects with OAB who were dissatisfied with their treatment due to lack of efficacy.

A prospective randomised controlled study to evaluate ankle dorsiflexion after cast immobiliation and percutaneous gastrocnemius lengthening, for neurologic healthy children (6-18) with an symptomatic equinus contracture.

By making this design study we wish to contribute to profound research on percutaneous gastrocnemius lengthening for for children with an equinus contracture and prevent publication bias for this open-labelled randomized trial.

Protocol I2R-MC-BIAO;
The Impact of LY2605541 versus Insulin Glargine for Patients with Type 1 Diabetes Mellitus Treated with Preprandial Insulin Lispro: a Double-Blind, Randomized, 52 Week Study ;The IMAGINE 3 Study;

The primary objective is to demonstrate that glycemic control, as measured by hemoglobin A1c(HbA1c) at 52 weeks for LY2605541 is noninferior to insulin glargine, when each is combined with preprandial insulin lispro, in patients with type 1 diabetes…

Effect of a cognitive behavioral intervention with or without a Functional Capacity Evaluation on work ability in patients with musculoskeletal pain

To measure whether adding a FCE to a cognitive behavioral intervention will improve work ability, quality of life and self efficacy.

A randomized clinical trial to study results of vaginoplasty with and without the use of additional full thickness skin graft in male to female transsexuals

The aim of this study is to measure if there are differences in maintaining vaginal depth and in aesthetic results between patients who underwent construction of a neo-vagina with penile skin only, or with penile skin combined with FTG.

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of the Effects of Ranolazine on Major Adverse Cardiovascular Events in Subjects with a History of Chronic Angina Who Undergo Percutaneous Coronary Intervention with Incomplete Revascularization

The primary objective of this study is to:• Evaluate the efficacy of ranolazine as compared with placebowhen used as part of standard medical therapy in chronicangina subjects with incomplete revascularization post percutaneous coronary intervention…

Effects of melatonin treatment, light therapy, and sleep improvement on psychosocial, cognitive, and behavioural outcomes in children with Delayed Sleep Phase Syndrome and their parents

The general aim of the present study is to investigate, in a longitudinal-experimental design, the effects of melatonin treatment and light therapy in children on sleep, health, and various psychosocial, behavioural, and cognitive outcomes. A second…