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A multi-site randomized controlled trial comparing Schema Therapy and Dialectical Behavior Therapy for borderline personality disorder: A framework for the study of (differential) change processes and the empirical search for treatment selection criteria

The aim of the present study is to optimize treatment selection by examining patient characteristics that predict (differential) treatment response across DBT and ST. These characteristics will be investigated and converted to actuarial formulas (…

Optimizing patient experience during cardiac stress testing

Primary objective: To determine whether adding information and coaching support to the standard diagnostic testing environment for the inducibility of myocardial ischemia improves patient psychological wellbeing.The role of the testing environment…

A Randomized, Open-label Phase 2 Clinical Trial of BMS-986012 in Combination with Carboplatin, Etoposide, and Nivolumab as First-line Therapy in Extensive-stage Small Cell Lung Cancer

This study has been transitioned to CTIS with ID 2024-510700-36-00 check the CTIS register for the current data. Study CA001-050 is a Phase 2 randomized, open label, multicenter clinical study designed to assess the safety and tolerability, of…

Distal Evaluation of Functional Performance With Intravascular Sensors to Assess the Narrowing Effect: Guided Physiologic Stenting;Substudy: Characterization of Intermediate Lesions

• Demonstrate that PCI guided by iFR Co-registration is associated with superior clinical outcomes compared to PCI guided by angiography alone• To evaluate the cost-effectiveness of physiology guidance with SyncVision compared to a standard of care…

Androgen Deprivation therapy for Oligo-recurrent Prostate cancer in addition to radioTherapy

This study has been transitioned to CTIS with ID 2024-511252-41-00 check the CTIS register for the current data. The aim of the current study is to extend the time to develop new disease progression in prostate cancer patients with recurrent disease…

A Phase 3, Randomized, Double-blind Trial of Pembrolizumab (MK-3475) Plus Enzalutamide Versus Placebo Plus Enzalutamide in Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC) (KEYNOTE-641)

This study has been transitioned to CTIS with ID 2022-500785-10-00 check the CTIS register for the current data. 1) To compare pembrolizumab plus enzalutamide versus placebo plus enzalutamide with respect to overall survival (OS)2) To compare…

Intravascular Ultrasound Guidance for Complex High-Risk Indicated Procedures

To assess the superiority of an IVUS-guided approach versus a qualitative angio-guided approach in patients with complex coronary lesions undergoing PCI.

LBL 2018 - International cooperative treatment protocol for children and adolescents with lymphoblastic lymphoma

This study has been transitioned to CTIS with ID 2023-508101-24-00 check the CTIS register for the current data. The primary objective of the first randomized question (R1) open for allLBL patients (pts) of the core study cohort, is to evaluate…

A PHASE III, MULTICENTER, RANDOMIZED, OPEN-LABEL STUDY OF
ATEZOLIZUMAB (ANTI-PD-L1 ANTIBODY) PLUS BEVACIZUMAB VERSUS
ACTIVE SURVEILLANCE AS ADJUVANT THERAPY IN PATIENTS WITH
HEPATOCELLULAR CARCINOMA AT HIGH RISK OF RECURRENCE AFTER
SURGICAL RESECTION OR ABLATION

This study has been transitioned to CTIS with ID 2023-504303-86-00 check the CTIS register for the current data. Primary objective:To evaluate the efficacy of atezolizumab plus bevacizumab compared with active surveillance on the basis of recurrence…

DRIGITAT: Doppler Ratio In fetal Growth restriction Intervention Trial At (near) Term

Does, in late preterm fetuses identified as small-for-gestational-age (SGA), timing of delivery based on abnormal umbilicocerebral ratio (UCR) improve neurodevelopmental outcome?

A Stratification trial to determine key immunological factors predicting Tofacitinib efficacy in Psoriatic Arthritis (PsA). TOFA-PREDICT

This study has been transitioned to CTIS with ID 2024-510903-12-00 check the CTIS register for the current data. Primary objective:Identify pre-treatment profiles with integrated clinical, transcriptomic, metabolomic, proteomic, flow cytometric, and…