Search for a trial

European Fans in Training (EuroFIT): A multicentre randomised controlled trial of a gender-sensitised programme to increase physcal activity and reduce sedentary time delivered to men aged 30-65 in elite European football clubs

The main aim of the EuroFIT trial is to assess the effectiveness and cost-effectiveness of the EuroFIT programme in supporting men to achieve an increase of at least 1000 steps per day (about 10 minutes on average per day, or 70 minutes per week)…

Phase III Randomized Double-Blind Trial of Bepanthen® Cream Versus Cetomacrogol Cream in the Prevention of Papulopustular eruption in Patients Receiving Epidermal Growth Factor Receptor Inhibitors (EGFRI): BeCet

To assess the preemptive effect of Bepanthen® on decreasing the incidence of specific >= grade 2 dermatological side effects of interest in respect of compliance to EGFRI agents, HRQoL and the adherence during the 6-week skin treatment period…

The effect of vitamin D-supplementation on insulin sensitivity in non-western immigrants in the Netherlands

To assess whether supplemention of vitamin D3 (1200 IU/day) in vitamin-D deficient non-western immigrants at risk for type 2 diabetes mellitus can improve the insulin resistance and betacell function as well.

PRODEO: PROfylactic Haloperidol in patients defined as high risk for DElirium with delirium risk mOdel

Research questionWill prophylactic administration of haloperidol to patients with a high risk of developing a delirium according to DEMO, reduce the incidence of a delirium? HypothesesProphylactic administration of haloperidol in post-operative…

A Randomized, Double-Blind, Placebo-Controlled Study of Galcanezumab in Adolescent Patients 12 to 17 Years of Age with Chronic Migraine - the REBUILD-2

This study has been transitioned to CTIS with ID 2023-505835-11-00 check the CTIS register for the current data. PrimaryTo demonstrate the superiority of galcanezumab versus placebo in the prevention of migraine in an adolescent population (12 to 17…

A Randomized, Double-Blind, Placebo-Controlled Study of Galcanezumab in Patients 6 to 17 Years of Age with Episodic Migraine - the REBUILD-1

This study has been transitioned to CTIS with ID 2023-505836-36-00 check the CTIS register for the current data. Main Objective:To demonstrate the superiority of galcanezumab versus placebo in the prevention of migraine in (at least) 1 of the…

Comparison of clinical and radiographical outcomes following placement of hybrid and moderate rough implants in the posterior mandible of periodontally compromised patients: a 3-year randomized clinical trial

Thel aim of this project is to analyse hybrid implants placed in de posterior mandible of periodontally compromised patients and to compare the treatment outcome of either moderate rough or hybrid implants.

Effect of protein supplementation on fat free mass preservation after bariatric surgery, a randomized double-blind placebo-controlled trial.

The main aim of this study is to assess whether protein supplementation could prevent excessive fat free mass loss during the first year after bariatric surgery.

KopOpOuders for PTSD: Randomized controlled trial of a blended care preventive parenting intervention for parents with PTSD.

Main objective: to test the effectiveness of KOO-PTSD on parenting skills at the macro- and micro-level.Secondary objectives: to test the effectiveness of KOO-PTSD on perceived parenting competence, social support, parenting stress, child…

FiberUP in clinical practice

To investigate the feasibility of increasing preoperative dietary fiber intake in CRC patients undergoing surgery via 1) personalized dietary advice (Vezel-UP tool), or 2) vegetable product containing natural fibers (WholeFiber) compared to 3)…

The Vold-study: The effect of a 12-week self-composed vegan diet with or without concurrent resistance exercise on thigh muscle volume in older adults

Primary: To assess the effects of a 12-week self-composed vegan diet in comparison to an omnivorous diet on thigh muscle volume (TMV) in community-dwelling older adults. And to assess the effect of a 12-week self-composed vegan diet combined with…

Phase 2, Multicenter, Randomized, Parallel, 3-arm, Placebo-controlled Study to Assess Efficacy and Safety of CDR132L in Patients with Reduced Left Ventricular Ejection Fraction (<= 45%) After Myocardial Infarction (HF-REVERT)

This study has been transitioned to CTIS with ID 2023-507569-24-00 check the CTIS register for the current data. This is a Phase 2, multicenter, randomized, parallel, 3-arm, placebo-controlled study to assess theefficacy and safety of CDR132L in…

A placebo-controlled, double-blind randomized trial evaluating the effect of etidronate in young patients with pseudoxanthoma elasticum on ectopic mineralization.

This study has been transitioned to CTIS with ID 2024-512133-33-00 check the CTIS register for the current data. Primary Objective To determine if 24 months of treatment with etidronate halts the progression of arterial calcification in the legs and…

Protein and calorie restriction as treatment for prevention of cardiotoxicity in women receiving chemotherapy.

To investigate the effects of a 5-day diet with 30% caloric and 70% protein restriction on cardiotoxicity induced by anthracycline treatment in women with triple negative or hormone receptor-positive breast cancer. The biomarker high-sensitivity…

Spinal Muscular Atrophy Randomized Controlled Trial on Cough Techniques
(Patient tailored airway clearance in patients with Spinal Muscular Atrophy: a randomized controlled trial comparing air stacking and mechanical insufflation-exsufflation.)

The aim of this study is to compare the effect of twice daily MI-E to twice daily AS with MAC on increase of PECF in patients with SMA with weak cough over a period of 3 years.

Non-invasive vagus nerve stimulation in acute ischemic stroke.

The main objective will be to investigate whether treatment with nVNS on top of best medical practice in acute ischemic stroke patients results in smaller infarct volumes compared with the infarct volumes of patients not treated with nVNS.

ACTION-1: ACT Guided Heparinization During Open Abdominal Aortic Aneurysm Repair, a Randomised Trial.

Primary Objective: To establish that ACT guided heparinization results in safe and optimal anticoagulation during open AAA repair. We hypothesize that ACT guided heparinization will result in a decrease of thrombo-embolic complications, without a…

Slow-SPEED-NL: Slowing Parkinson's Early through Exercise Dosage-Netherlands

The primary objective is to determine the feasibility of a remote intervention study to promote physical activity in people with iRBD. The secondary objectives are to determine the longitudinal effect of an exercise intervention in people with iRBD…