Search for a trial

Mindfulness versus Cognitive Behavioural Therapy in Tinnitus Patients - A Randomized Controlled, Non Inferiority Trial

Primary Objective: The primary objective is to determine whether MBCT is non inferior in the effectiveness on TFI reduction as CBT in adults with chronic tinnitus. Non inferioirty would be declared if the mean decrease in TFI score for MBCT is no…

Neural mechanisms of noradrenaline and cortisol effects on memory accuracy vs. generalization over time

The aim of this experiment is to determine the differential effects of noradrenaline and cortisol on memory accuracy versus generalization and to investigate the divergent effects of these stress mediators on the neural mechanisms underlying the…

An Open Label, Randomized Phase 2 Trial of Pomalidomide/Dexamethasone With or Without Elotuzumab in relapsed and refractory Multiple Myeloma.

The study will look at patients with relapsed (returned after prior treatment) and refractory (not responsive to prior treatment) multiple myeloma. The research aims to compare a new drug called elotuzamab combined with standard of care (…

A Double-blind, Randomized, Placebo-controlled, Multicenter Study to Assess the Efficacy and Safety of Omecamtiv Mecarbil on Mortality and Morbidity in Subjects With Chronic Heart Failure With Reduced Ejection Fraction

Primary Objective:- to evaluate the effect of treatment with omecamtiv mecarbil (OM) compared with placebo on the time to cardiovascular (CV) death of first HF event, whichever occurs first, in subjects with chronic HF with reduced ejection fraction…

Stress reduction in formerly preeclamptic women; sofa or sports?

To investigate whether online mindfulness-based stress reduction (MBSR) therapy and an aerobe training intervention both leading to stress reduction and reduced circulatory risk in formerly preeclamptic women with increased mental stress levels…

Virtual Reality Training for Aggression Control in a Dutch prison-based population - a randomized controlled trial.

The primary objective of this randomized controlled trial is to investigate the effect of the VR-TRAC on aggression in a prison-based population.

BioNIR Ridaforolimus Eluting Coronary Stent System (BioNIR)
European Angiography Study

The BioNIR is non-inferior to the Resolute for the primary angiographic of in-stent late loss at 6 months

Preservation of both cruciate ligaments as essential step to the forgotten knee. Do we need the anterior cruciate
ligament for better functional outcomes?
A randomized controlled gait analysis trial

Primary Objective:To evaluate tibia rotation after TKA with the Vanguard total knee system with either the XP tibia implant compared to thestandard CR tibia implant.Secondary Objective:Comparing operative, clinical and radiological outcome of either…

A Multicenter, Randomized, Double-Blind Study to Evaluate Higher Versus Standard Adalimumab Dosing Regimens for Induction and Maintenance Therapy in Subjects with Moderately to Severely Active Crohn's Disease and Evidence of Mucosal Ulceration.

The objective of Study M14-115 is to evaluate efficacy and safety of higher induction and maintenance dosing regimens in subjects with moderately to severely active Crohn's disease.

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Ramucirumab plus Docetaxel versus Placebo plus Docetaxel in Patients with Locally Advanced or Unresectable or Metastatic Urothelial Carcinoma Who Progressed on or after Platinum-Based Therapy.

The primary objective of this study is to compare the progression-free survival (PFS) of ramucirumab in combination with docetaxel with the PFS of placebo in combination with docetaxel, in patients with locally advanced or unresectable or metastatic…

A Double-Blind, Randomized, Multicenter Study of Higher Versus Standard Adalimumab Dosing Regimens for Induction and Maintenance Therapy in Subjects with Moderately to Severely Active Ulcerative Colitis

The objective is to evaluate safety and efficacy of higher induction and maintenance dosing regimens in subjects with moderately to severely active Ulcerative Colitis (UC).

A Phase 1b, Randomized, Double-Blind, Placebo-Controlled, Multi-Center, Single Ascending Dose Study to Assess the Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of DS-1040b when Added to Standard of Care Anticoagulation Therapy in Subjects with Acute
Submassive Pulmonary Embolism.

The primary objective of this study is to evaluate the safety and tolerability using bleeding as the primary endpoint. Secondarily, this study will serve as a proof-of concept by evaluating the effect that DS-1040b administration has on total…

Study protocol for a randomized clinical trial of a continuous butylscopolamine infusion versus a placebo in patients with a renal colic not responding to oral NSAIDs

The purpose of this study is to analyse the effect on pain reduction of butylscopolamine in a continuous intravenous infusion compared to a placebo in patients with renal colics not responding to oral NSAIDs.

Cumulative live birth rate after cleavage-stage(day three) or blastocyst stage(day five) embryo transfer in good prognosis IVF/ICSI cycles.

To determine whether blastocyst stage embryo transfers improve the cumulative live birth rate compared with cleavage stageembryo transfers in IVF/ICSI treatments

Swiss trial of decompressive craniectomy versus best medical treatment of spontaneous supratentorial intracerebral hemorrhage: a randomized controlled trial

The primary objective of this randomized controlled trial is to determine whether decompressive surgery and best medical treatment in patients with spontaneous ICH will improve outcome compared to best medical treatment only. Secondary objectives…

A randomized controlled trial comparing venous stenting with conservative treatment in patients with Deep Venous Obstruction

Primary Objective: Measure QoL (VEINES QoL/Sym) change in patients with DVO at one year after PTA and stenting compared to conventional therapy (short class II elastic compressions stockings, exercise, lymph drainage therapy and the use of (pain)…

An adaptive seamless randomized, double-blind, placebo-controlled, dose ranging study to investigate the efficacy and safety of LNP023 in primary IgA nephropathy patients

To evaluate the dose response relationship of LNP023 on the reduction in proteinuria versus placebo after 90 days of treatment in patients with IgA nephropathy.

A randomized controlled trial on the effect of beetroot juice on VO2max in patients undergoing a minimally invasive esophagectomy

The primary aim of this study is to investigate the added effect of one consecutive week of BRJ consumption on VO2max in prehabilitated patients scheduled to undergo a minimally invasive esophagectomy for cancer.

Efficacy, safety and tolerability of a bowel cleansing preparation (Eziclen®/Izinova®)
in paediatric subjects undergoing colonoscopy: a Phase III, multicentre, randomised, comparative study versus Klean-Prep® (PEG-Electrolytes), administered on the day before colonoscopy,
Investigator-blinded, non-inferiority in adolescents of 12 to 17 years of age (inclusive) > 40 kg.

Primary objective:To demonstrate that Eziclen, given on the day before colonoscopy has non-inferior efficacy to Klean-Prep on colon cleansing in adolescents aged 12 to 17 years (inclusive) with a body weight > 40 kg, scheduled to undergo a…

PeRsonalIzed MEdicine in Rheumatoid Arthritis (PRIMERA trial): a multicenter, single-blinded, randomized controlled trial comparing usual care with a tailor-made approach

This study has been transitioned to CTIS with ID 2024-511530-12-01 check the CTIS register for the current data. We hypothesize that treatment of RA can be individualized by taking into account the presence of autoantibodies and quick response to…