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The added effect of oral ondansetron to care-as-usual on persisting
vomiting in children aged 6 months to 6 years, presenting at primary care
out of hours service with acute gastro-enteritis and concomitant vomiting

The primary objective is to determine the added effect of oral ondansetron to care-as-usual (including ORT) (CAU) on persisting vomiting within the first 4 hours after presentation at an out-of-hours primary care service (OHS) in children aged 6…

Effectiveness of a prenatally implemented parenting support intervention on preventing postpartum parental distress and enhancing infant well-being.

The primary objective is to assess the effect of the parenting support intervention on parental stress. Secondary objectives are the effect of theintervention on other parental outcomes (anxiety and depression, satisfaction with the parental role,…

Influence of early goal-directed therapy using arterial waveform cardiac output measurement in high-risk surgery

To determine whether early goal-directed therapy, aimed at optimizing cardiac output measured by arterial waveform analysis, improves outcome in high-risk, abdominal surgery.

The effect of concentrated beetroot juice with or without vitamin C on the levels of N-nitroso compounds in urine

The main aim of the study will be to compare the urinary N-nitroso compounds levels after intake of 70 ml of concentrated red beetroot juice containing 400 mg nitrate either with or without supplementation with 1 g vitamin C.

Neo-adjuvant chemotherapy followed by surgery versus surgery alone in high-risk patients with resectable colorectal liver metastases ;The CHARISMA randomized multicenter clinical trial

The primary study objective is to compare the efficacy, as assessed by overall survival, of surgery and neo-adjuvant chemotherapy to surgery alone in patients with resectable liver metastases of colorectal cancer and a high clinical risk score.…

SUCCESS STUDY; Smoking reduction by a smoking cessation strategy in the national cervical cancer screening program

We hypothesize that a smoking cessation strategy for smoking cervical cancer screening participants will increase their motivation to quit and will lead to an increased proportion of smokers performing a serious quit attempt. Eventually this will…

The value of completion axillary treatment in sentinel node positive breast cancer patients undergoing a mastectomy: a Dutch multicentre cohort study l

The study aim is to decrease the number of breast cancer patients receiving overtreatment of the axilla, in order to positively influence the axillary morbidity rate and quality of life. Therefore, we investigate whether completion axillary…

A Randomized Phase 3 Open Label Study of Nivolumab versus Bevacizumab and a Safety Study
of Nivolumab or Nivolumab in Combination with Ipilimumab in Adult Subjects with Recurrent
Glioblastoma (GBM)

This study will investigate whether treatment with Nivolumab is comparable to Bevacizumab in patients with Glioblastoma. We will measure this by comparing how many patients arestill alive after a certain period of time once they have started…

Ultra low-dose chest ct with iteratIve reconstructions as an alternative to conventional chest x-ray prior to heart surgery

To assess if information about aortic calcification obtained from routine preoperative ultra low-dose chest CT reconstructed with IR lowers the postoperative stroke rate in patients undergoing heart surgery by optimizing surgical strategy compared…

Prospective Open label study of Parenteral vs Enteral iron in Young IBD patients and Effect on physical fitness

To examine if intravenous administration of iron ismore efficacious than oral iron in improvement offitness scores, iron status and reduction of fatigue

RCT to investigate the quality of the of endometrial sample obtained by aspiration when performed before or after the SIS in postmenopausal women.

The primary objective is to investigate the quality (whether assessable by a pathologist or not) of the endometrial sample obtained by aspiration when performed directly before or after the SIS in postmenopausal women. Secondary objectives are to…

Treatment of bulimia nervosa and eating disorders not otherwise specified: Cognitive Behaviour Therapy versus Cognitive Therapy

The goal of this study is to learn whether:The above described CBT according to protocol is more effective than CT according to protocol without behavioral interventions (binge cue exposure with respons prevention and body exposure including…

Multi-center, randomized clinical trial to study the impact of in-hospital guidance for acutely decompensated heart failure treatment by predefined NT-proBNP targets (>30% reduction in NT-proBNP during admission) on the reduction of readmission rates and mortality

The primary objective of the present study is to demonstrate that NT-proBNP guidance during in-hospital treatment for acutely decompensated heart failure (to strive for >30% reduction) reduces readmissions and mortality and increases the…

Pre-emptive, OCT guided angioplasty of vulnerable, intermediate coronary lesions: a randomized trial

To determine the effect of the stenting of intermediate, vulnerable coronary lesions on the prevention of future ACS, in patients with residual non-obstructive CAD after PCI for myocardial infarction.

The role of executive functions in the efficacy of VR as pain relief during experimental pain

The primary objective is investigating the influence of Virtual Reality distraction on pain. The secondary objectives were, investigating if (1) the executive functions and catastrophizing thoughts influence the effect of VR as pain relief; (2) the…

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Effectiveness of ultrasound imaging in general practice: optimising the management of patients with non-chronic shoulder complaints.

To optimize the management of non-chronic shoulder pain in primary care by the introduction of ultrasound as a diagnostic triage tool. The following research questions will be addressed:1. What are the effects of diagnostic ultrasound and its…

Cortrak bedside Or Regular Endoscopic placement of nasoenteral feeding tubes in surgical patients (CORE): a randomized controlled multicenter non-inferiority trial

To determine the (cost-)effectiveness and budget impact EM-guided bedside placement as compared to endoscopic placement of a nasoenteral feeding tube in surgical patients.

What should be done in women with an incomplete evacuation of the uterus after treatment with misoprostol for miscarriage? An analysis of costs and effects.

To assess costs and effects of curettage versus expectant management in women with incomplete evacuation of a miscarriage, as diagnosed with sonography, after misoprostol.

A phase 2 multicentre randomized controlled comparative efficacy and safety study of Tiscover and AS210 in chronic (arterio-)venous ulcers

Determine the safety and efficacy of Tiscover compared to AS210 (acellular donor dermis, construct Tiscover is cultured on) for the treatment of chronic, therapy resistant (arterio-) veneus leg/foot ulcers in an out patient setting.