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The added effect of oral ondansetron to care-as-usual on persisting
vomiting in children aged 6 months to 6 years, presenting at primary care
out of hours service with acute gastro-enteritis and concomitant vomiting

The primary objective is to determine the added effect of oral ondansetron to care-as-usual (including ORT) (CAU) on persisting vomiting within the first 4 hours after presentation at an out-of-hours primary care service (OHS) in children aged 6…

Effectiveness of a prenatally implemented parenting support intervention on preventing postpartum parental distress and enhancing infant well-being.

The primary objective is to assess the effect of the parenting support intervention on parental stress. Secondary objectives are the effect of theintervention on other parental outcomes (anxiety and depression, satisfaction with the parental role,…

The effect of concentrated beetroot juice with or without vitamin C on the levels of N-nitroso compounds in urine

The main aim of the study will be to compare the urinary N-nitroso compounds levels after intake of 70 ml of concentrated red beetroot juice containing 400 mg nitrate either with or without supplementation with 1 g vitamin C.

Uniform FDG-PET guided gradient dose prescription to reduce late radiation toxicity (UPGRADE RT): a randomised controlled trial with dose reduction to the elective neck in head and neck squamous cell carcinoma

The UPGRADE-RT trial will investigate whether de-escalation of the elective radiation dose and introduction of an intermediate dose-level in the treatment of head and neck cancer will results in less radiation sequelae and improved quality of life…

A Randomized, Placebocontrolled, Double blind, Single Ascending Dose Study to Investigate Safety and Tolerability, Pharmacokinetics and Pharmacodynamics of JNJ-61393215 in Healthy Subjects

The primary objectives of this study in healthy subjects are:- To investigate the safety and tolerability of JNJ-61393215 versus placebo after single oral dose administration under fasted (ascending dose levels) and fed condition.- To characterize…

RCT to investigate the quality of the of endometrial sample obtained by aspiration when performed before or after the SIS in postmenopausal women.

The primary objective is to investigate the quality (whether assessable by a pathologist or not) of the endometrial sample obtained by aspiration when performed directly before or after the SIS in postmenopausal women. Secondary objectives are to…

Somatosensory electrical stimulation to augment skill acquisition and motor memory consolidation: An electroencephalography study

To determine the mechanisms underlying motor skill training, somatosensory electrical stimulation, and a combined intervention on motor skill acquisition, motor memory consolidation, and interlimb transfer in healthy younger and older adults.

Pre-emptive, OCT guided angioplasty of vulnerable, intermediate coronary lesions: a randomized trial

To determine the effect of the stenting of intermediate, vulnerable coronary lesions on the prevention of future ACS, in patients with residual non-obstructive CAD after PCI for myocardial infarction.

Mifepristone and misoprostol versus misoprostol alone for uterine evacuation after early pregnancy failure: a pilot study

Th**is study will compare sequential mifepristone and misoprostol (*M&M*) treatment versus misoprostol treatment alone, which is currently the standard medical treatment in the Netherlands.

The role of executive functions in the efficacy of VR as pain relief during experimental pain

The primary objective is investigating the influence of Virtual Reality distraction on pain. The secondary objectives were, investigating if (1) the executive functions and catastrophizing thoughts influence the effect of VR as pain relief; (2) the…

Self-monitoring and personalized feedback as a tool to boost depression treatment

The main aim of the ZELF-i project is to investigate the effectiveness of self-monitoring and personalized feedback as an add-on tool in the treatment of depression. By starting directly after intake, patients can make the most out of the usual…

Nociceptive-Level (NoL)-guided analgesia versus standard practice during general remifentanil/propofol anesthesia in ASA 1-3 patients

To guide the analgesic component of anesthesia using the Nociceptive Level (NoL) index in ASA 1-3 patients under general anesthesia for elective abdominal surgery.

A First-in-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Ascending Oral Doses of DNL104 in Healthy Subjects

- Investigate the safety and tolerability of single ascending doses of DNL104 in healthy volunteers.- Characterize the pharmacokinetics of DNL104 in plasma, CSF, and urine.- Characterize the effect of a high fat meal on the pharmacokinetics of…

Effects of collagen peptide supplementation on knee JOINT discomfort during and after repetitive low-INtensity exercise

To study the effects of collagen peptide supplementation on knee joint discomfort in active elderly with activity-related knee discomfort.

A randomized, double-blind, placebo-controlled, parallel-group study to investigate the safety, tolerability, and pharmacodynamics of JNJ-54175446 in subjects with major depressive disorder.

Primary objective:-To investigate the safety and tolerability of JNJ-54175446 in subjects with major depressive disorder.Secondary objectives:-Investigate the effect of JNJ-54175446 versus placebo on total sleep deprivation-induced changes in…

Free-hand versus navigation guided percutaneous liver tumor ablation

The objective of the study is to compare free-hand needle placement with navigation guided needle placement.

A randomized controlled trial comparing Dried Blood Spot sampling to venous sampling for Therapeutic Drug Monitoring in tacrolimus using kidney transplant patients: a cost minimization analysis.

To determine the difference in the amount (average per patient) of clinical check-ups performed in the hospital for the DBS and the non-DBS group. To compare the total economic burden for the intervention and non-intervention groups from a societal…

ReActiv8 Implantable Neurostimulation System for Chronic Low Back Pain

To evaluate the safety and efficacy of ReActiv8 for the treatment of adults with Chronic Low Back Pain and no prior spine surgery when used in conjunction with medical management.

Evaluation of a novel alternative protein source to stimulate post-exercise muscle protein synthesis

From p11 of C1 protocol document:1) To define the characteristics of mealworm protein ingestion on protein/digestion absorption kinetics and both whole-body and myofibrillar muscle protein synthesis after a single bout of resistance exercise in…

A Phase 4, Double-Blind, Randomized, Placebo-Controlled Multicenter Study to Assess the Safety and Efficacy of Adalimumab Used in Conjunction with Surgery in Subjects with Moderate to Severe Hidradenitis Suppurativa

Primary objective:Assess the safety and efficacy of adalimumab prior to surgery in subjects with moderate to severe HS who are surgical candidates.Secondary objectives:Assess the impact of adalimumab on the planned HS surgical site before surgery,…