30 results
- to evaluate (cost-) effectiveness of a personalized health intervention among workers of 40 years and older with high physical work demands to contribute to a reduction in CVD and sustainable employability.
The objective of the study can be defined into two goals1. Reduction of CIN using the Renalguard with furosemide forced diuresis in patients known with chronic kidney failure whom require an endovascular intervention of the lower limbs. 2. Early…
Objective: Our main objective is to evaluate the additional effect of omega-3 fatty acids on maximal walking distance in patients with IC receiving SET. Our secondary objective is to evaluate the effect of omega-3 fatty acids on hemorheological…
Primary Objective: To study effects of RWPs on insulin sensitivity, glucose tolerance, microvascular function (skin and muscle), insulin-mediated microvascular responsiveness, and blood pressure.Secondary objectives: To study effects of RWPs on…
To compare ticagrelor with clopidogrel treatment on the risk of cardiovascular death, myocardial infarction and ischaemic stroke in patients with established peripheral artery disease.
The primary goal of this trial is to demonstrate that a physical activity program, which consists of an exercise program and follow-up care, under supervision of a specialized physiotherapist can prevent the frequently observed decline in global…
To examine the impact of walking training on the lifetime risk for cardiovascular disease in DMT2 and DMT1 patients and to assess whether these effects are preserved 3 months after the Nijmegen 4-Day marches. Results will be compared with a control…
Objectives:The following objectives are designed to address the effects of SCH 530348 when administered orally in addition to the standard of care for a minimum of 1 year in subjects with documented atherosclerotic disease.Primary Objective: The…
Evaluation of the rise in serum creatinine and the incidence of CIN following angiography in patients treated with a short hydration regime during 1 hour with sodium bicarbonate compared to a hydration regime with saline during 6-24 hours.
The purpose of this study is to demonstrate the beneficial effect of ivabradine on plaque burden, morphology and composition, as well as on arterial wall shear stress (WSS) in patients with CAD who have a clinical indication for coronary angiography…
To study the protective effect of pretreatment (both 3 day and 7 day) with rosuvastatin and atorvastatin on flow mediated dilation after 15 minutes ischemia and 15 minutes reperfusion.
The main objective of the study is to evaluate the effectiveness of an individually- based lifestyle intervention for male workers with an elevated CVD risk in the construction industry in The Netherlands.
To assess the effect of increased intake of cis9,trans11-CLA on development of atherosclerosis, as assessed with aortic pulse wave velocity and on alternative biomarkers.
The primary aim of this study is to investigate if a tight multiple cardiovascular risk reduction program is effective in reducing progression of Intima media thickness progression (subclinical atherosclerosis) in patients with RA compared to usual…
This prospective randomised study has the primary objective to prove a reduction of postoperative wound infections after direct preoperative use of a microbial sealant in the form of Integuseal for vascular procedures on lower extremities. We aim at…
The objective of this trial is to investigate whether remote ischemic preconditioning or remote ischemic postconditioning improves clinical outcome after coronary artery bypass grafting surgery, as measured by the incidence of postoperative atrial…
The objective of this study is to investigate what the value is of SET after a radiological or surgical intervention for peripheral arterial disease in the aorto-iliacal, femoro-popliteal and crural segments in comparison with a control group.
To establish superiority of the biolimus-eluting (BiomatrixTM) stent compared with an otherwise identical bare-metal stent (GazelleTM) in acute ST-segment elevation myocardial infarction (STEMI) in terms of the composite endpoint of cardiac death,…
The primary objective of this study is to determine whether clopidogrel + best medical treatment is superior to best medical treatment only in preventing:A) cardiovascular death, MI, stroke, or severe ischemia of the coronary or peripheral arterial…
The aim of this clinical study is to investigate whether the non-anaesthetic noble gas helium induces EPC and LPC of human endothelium in vivo.