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Randomized trial of Legflow® Paclitaxel eluting balloon (LPEB) with stentplacement vs. standard PTA with stentplacement for the treatment of intermediate (>5 cm and < 15 cm) and long (>15 cm) lesions of the superficial femoral artery (SFA). The RAPID trial.

The primary objective is to assess the difference in absence of binary restenosis rate of endovascular treatment of intermediate and long lesions of the superficial femoral artery with the Legflow® PEB and nitinol stent, when compared to uncoated…

IOinated contrast DILution in digital subtraction angiography of the limb:
a randomized controlled trial with three different concentrations of iodine

To compare the confidence of the interventional radiologist in diagnosing and treating arterial stenoses and occlusions by digital subtraction angiography with contrast concentrations of 300, 240 and 140 mg iodine per ml. Also, we will compare the…

Reducing the amount of contrast medium in CTAs of the abdominal aorta using a multiphasic injection technique

Primary Objective: Is it possible to reduce the amount of contrast medium used in CTAs of the abdominal aorta by injecting the contrast medium with a multiphasic protocol, without losing image quality?Secondary Objective: What does the contrast…

Reducing the amount of contrast medium in CTAs of the abdominal aorta using a multiphasic injection technique and a test bolus to reduce the bolus volume

Primary Objective: Is it possible to reduce the amount of contrast medium used in CTAs of the abdominal aorta by injecting the contrast medium with an exponential decay and with a bolus reduction, without losing image quality?Secondary Objectives:…

Reducing the effective radiation dose and the amount of contrast medium in CTA of the abdominal aorta

Primary Objective: Is it possible to reduce the effective radiation dose and reduce the amount of contrast medium used in CTAs for patients, without losing image quality, using a reduced tube voltage protocol (80 kV) or CARE kV scanning protocol…

Effect of transient high blood glucose on brachial artery function

To study the effect of transient high blood glucose level on the brachial artery FMD response, and to determine the reproducibility of the measurements and observed effect.

Exploratory research into the effect of temporarily withdrawal of PPIs (Proton Pump Inhibitor) use, to reduce the stomach wall uptake of 99mTc-Sestamibi in a myocardial perfusion imaging

4.1 The main questionWhat is the effect of temporarily stopping PPI use on the stomach wall uptake of Tc99m Sestamibi with a myocardial perfusion?4.2 Sub-questions:- What is the relative maagwanduptake a myocardial perfusion Tc99m Sestamibi with…

Novel transcatheter arterial embolization for treatment of knee osteoarthritis: a randomized sham-controlled clinical trial

The main objective is to assess whether transcatheter arterial embolization of neovessels in patients with symptomatic knee OA results in significant pain reduction after 4 months compared to sham treatment.We hypothesize that novel transcatheter…

Virtual Monoenergetic Imaging of the Lower Extremities Using Dual-Energy CT Angiography in Patients with Diabetes Mellitus: A Randomized Controlled Trial

Several observational studies have been published evaluating DECTA for imaging of the lower legs, comparing this technique with conventional CTA. However, to the best of our knowledge, no randomised controlled trial has been conducted comparing both…

Intravascular Ultrasound Guidance for Complex High-Risk Indicated Procedures

To assess the superiority of an IVUS-guided approach versus a qualitative angio-guided approach in patients with complex coronary lesions undergoing PCI.

Efficacy of Diltiazem to improve coronary microvascular dysfunction: A randomized clinical trial

This study has been transitioned to CTIS with ID 2024-512030-15-00 check the CTIS register for the current data. Our primary objective is to assess the effect of diltiazem on coronary microvascular function as assessed by coronary reactivity testing…

Placebo-controlled double-blind randomized controlled trial investigating vitamin K supplementation on vascular calcification propensity in vitamin K deficient renal transplant recipients

To study the effect of vitamin K supplementation on calcification propensity and vitamin K status in RTRs with vitamin K deficiency.

Effects of vitamin K2 supplementation on [18]F-NaF PET/MRI in patients with carotid and coronary artery disease

To test our hypothesis that vitamin K2 supplementation will induce a clinically relevant reduction in the degree of micro-calcification from carotid artery disease patients, when comparing to a placebo, after 3 months.