163 results
"The primary objective of this study is to compare the clinical therapeutic effects of intravenous DP-b99 at adose of 1.0 mg/kg initiated within nine hours of stroke onset and administered daily over 2 hours for 4consecutive days versus placebo…
The primary efficacy variable is the change in PV from baseline as assessed by 3 D ultrasonography after 78 weeks of double-blind treatment with OM 20-40 mg daily compared to ATE 50-100 mg daily.Secondary efficacy variables:Change from baseline PV…
The primary objective of the study is to demonstrate that among subjects undergoing primary PCI for anterior STEMI treated with a bivalirudin monotherapy anticoagulation strategy, the intracoronary infusion of an abciximab bolus with or without…
The main objective is to investigate whether and at what dose vitamin K2 increases carboxylation of MGP. Secondary objective is to investigate the effect of vitamin K2 on markers of CVD (osteocalcin, blood lipids, inflammatory factors and insulin…
Primary Objective: Is it possible to reduce the amount of contrast medium used in CTAs of the abdominal aorta by injecting the contrast medium with a multiphasic protocol, without losing image quality?Secondary Objective: What does the contrast…
Primary Objective: Is it possible to reduce the amount of contrast medium used in CTAs of the abdominal aorta by injecting the contrast medium with an exponential decay and with a bolus reduction, without losing image quality?Secondary Objectives:…
The study investigates the inhibition of restenosis by the Paclitaxel-eluting PTA balloon Freeway versus stenting-PTA or PTA alone in the treatment of de-novo occluded, stenotic or reoccluded, restenotic superficial femoral (SFA) or popliteal…
The primary goal of this trial is to demonstrate that a physical activity program, which consists of an exercise program and follow-up care, under supervision of a specialized physiotherapist can prevent the frequently observed decline in global…
1. To proof local delivery of intravenously administered liposomal glucocorticoids (Nanocort) in subjects with peripheral artery disease by demonstrating Nanocort in atherosclerotic tissue. 2. To determine the differences between cytokine production…
A practical demonstration project in 5 European countries to show that intensive smoking intervention during a preventive cardiovascular risk management programme for patients with cardiovascular (CVD) or other atherosclerotic disease, asymptomatic…
To validate and extend findings from the TACT sytudy group as well as our own preliminary data in a randomized, placebo controlled study in patients with and without diabetes.
ObjectiveTo investigate the performance of paclitaxel-coated balloon expandable stainless steel coronary stent for the treatment of infrapopliteal stenoses and occlusions in patients with critical limb ischemia compared to percutaneous transluminal…
To examine the impact of walking training on the lifetime risk for cardiovascular disease in DMT2 and DMT1 patients and to assess whether these effects are preserved 3 months after the Nijmegen 4-Day marches. Results will be compared with a control…
Objectives:The following objectives are designed to address the effects of SCH 530348 when administered orally in addition to the standard of care for a minimum of 1 year in subjects with documented atherosclerotic disease.Primary Objective: The…
The purpose of this study is to assess the safety of the new modified release (MR) formulation of ivabradine administered orally, at titrated doses if necessary, in patients with stable coronary artery disease (CAD) with or without angina pectoris.
To compare in a prospective randomised way the effect of two different immunosuppressive regimens - mTOR-based regimen or CNI-based regimen - on the progression of coronary artery calcification in renal transplant patients measured at baseline, 1, 2…
Primary Objective: Is it possible to reduce the effective radiation dose and reduce the amount of contrast medium used in CTAs for patients, without losing image quality, using a reduced tube voltage protocol (80 kV) or CARE kV scanning protocol…
Evaluation of the rise in serum creatinine and the incidence of CIN following angiography in patients treated with a short hydration regime during 1 hour with sodium bicarbonate compared to a hydration regime with saline during 6-24 hours.
The purpose of this study is to demonstrate the beneficial effect of ivabradine on plaque burden, morphology and composition, as well as on arterial wall shear stress (WSS) in patients with CAD who have a clinical indication for coronary angiography…
The aim of the research is to demonstrate a possible significant difference in procedural success and / or clinical success of duplex-guided PTAs compared with conventional PTA in an RCT.The study describes the above hypothesis and has led to the…