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Effect of simvastatin on myocardial triglyceride accumulation, cardiac function and al vessel wall thickness in patients with type 2 diabetes mellitus

To study the possible beneficial effect of simvastatin on accumulation of triglycerides in the myocardium of patients with DM2 and the effect on vessel wall thickness using magnetic resonance imaging and spectroscopy

Comparison of Biolimus Eluted from a Erodable Stent Coating with Bare-metal Stents in Acute ST-elevation Myocardial Infarction & In Vivo 3-Vessel Assessment of Time-Related Changes of Culprit and Non-Culprit Lessions by Grayscale IVUS, IVUS-VH and OCT in Acute Myocardial Infarction.

To establish superiority of the biolimus-eluting (BiomatrixTM) stent compared with an otherwise identical bare-metal stent (GazelleTM) in acute ST-segment elevation myocardial infarction (STEMI) in terms of the composite endpoint of cardiac death,…

Does ATP cause Annexin A5 targeting in the human forearm?

To study the impact on intra-arterial ATP infusion on Annexin A5 targeting.

A Clinical Evaluation of the XIENCE TM V Everolimus Eluting Coronary Stent System in the Treatment of Patients with de novo Coronary Artery Lesions

The purpose of this Clinical Evaluation is a continuation in the assessment of the performance of the XIENCE* V Everolimus Eluting Coronary Stent System (XIENCE* V EECSS) in the treatment of patients with de novo coronary artery lesions.

Clopidogrel for the prevention of late cardiac events in patients with asymptomatic perioperative acute coronary syndrome.

The primary objective of this study is to determine whether clopidogrel + best medical treatment is superior to best medical treatment only in preventing:A) cardiovascular death, MI, stroke, or severe ischemia of the coronary or peripheral arterial…

Organ protection by noble gases * Helium induced Early and Late Preconditioning (HELP) in human endothelium

The aim of this clinical study is to investigate whether the non-anaesthetic noble gas helium induces EPC and LPC of human endothelium in vivo.

High dose adenosine in acute myocardial infarction study

This study is designed to investigate the limiting effect on infarct size of high dose intravenous adenosine during primary angioplasty

Effects of a mindfulness based stress reduction program on psychological, cognitive and physiological measures in PCI-patients.

The aim is to evaluate the effectivity of training in mindfulness with patient who underwent a PCI-procedure on different variables: (i) psychological wellbeing (mood, anxiety, depression and quality of life), (ii) clinical relevant physiological…

Internet-based vascular Riskfactor Intervention and Selfmanagement study

The objective of the proposed study is to evaluate the efficacy on risk factor management and toevaluate cost-effectiveness of an internet-based risk factor management program for patients at highcardiovascular risk.The research questions are…

The Real-World Endeavor Resolute versus Xience V Drug-Eluting Stent Study in Twente

Primary research questions:* To investigate whether the clinical outcome following the randomized implantation of the Endeavor Resolute® versus XIENCE V® drug-eluting stent is similar, as assessed in a non-inferiority setting by comparing target-…

"HIV (ge) VAT" Vascular care in HIV infected patients; Reduction of vascular risks in HIV-1 infected patients
A pilot study

To study the impact of treating potentially modifiable vascular risk factors in HIV-1 infected patients by a nurse-led vascular intervention program

A PHASE 3 DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED STUDY TO EVALUATE THE SAFETY AND EFFICACY OF AMG0001 IN SUBJECTS WITH CRITICAL LIMB ISCHEMIA

The primary objectives of the clinical trial are:1. To estimate the treatment benefit (AMG0001 compared to placebo), in terms of a combined endpoint (major amputations or all-cause death)2. To evaluate the overall safety and efficacy of AMG0001.

DISCOVER: Dutch Iliac Stent trial: COVERed balloon-expandable versus uncovered balloon-expandable stents. A prospective, randomized, controlled, triple-blind, multi-center trial comparing PTFE-covered balloon-expandable stents versus uncovered balloon-expandable stents in patients with advanced occlusive disease of the common iliac artery in terms of morphologic, clinical, and hemodynamic outcome after a 2-year follow-up.

Our primary objective is to assess the absence of binary restenosis rate, the reocclusion rate and target-lesion revascularization rate of endovascular treatment of advanced atherosclerotic lesions of the common iliac artery with a balloon…

A Randomized, Multi-Center, Placebo-Controlled, Parallel Group Study to Determine the Effects of AMG 145 Treatment on Atherosclerotic Disease Burden As Measured By Intravascular Ultrasound in Subjects Undergoing Coronary Catheterization (GLAGOV study, 20120153)

Primary: To evaluate the effect of AMG 145 on the change in burden of coronary atherosclerosis as measured by percent atheroma volume (assessed with intravascular ultrasound, IVUS) in patients with coronary artery disease requiring angiography for a…

Exploratory research into the effect of temporarily withdrawal of PPIs (Proton Pump Inhibitor) use, to reduce the stomach wall uptake of 99mTc-Sestamibi in a myocardial perfusion imaging

4.1 The main questionWhat is the effect of temporarily stopping PPI use on the stomach wall uptake of Tc99m Sestamibi with a myocardial perfusion?4.2 Sub-questions:- What is the relative maagwanduptake a myocardial perfusion Tc99m Sestamibi with…

Does Applying More Oxygen Cure Lower Extremity Sores?

To assess the relative effectiveness of HBOT as an adjunct to standard wound care in terms of preventing amputations and improving wound healing in ischemic diabetic ulcers, and its cost-effectiveness. Secondary objectives are to assess the patients…

A phase 4, monocenter, randomized, double-blind, comparator-controlled, 3-armed parallel mechanistic intervention trial to assess the effect of 8-week empagliflozin (SGLT-2 inhibitor) monotherapy, followed by 8-week empagliflozin and linagliptin (DPP-4 inhibitor) combination therapy versus 8-week linagliptin monotherapy, followed by 8-week linagliptin and empagliflozin combination therapy versus 8-week gliclazide (Sulfonylurea derivate), followed by 8-week gliclazide intensification therapy on r

To examine the effects of mono- and combination therapy with linagliptin and empagliflozine on renal hemodynamics

On-Site Augmented-Reality Computed Tomography Plus Angiography versus Angiography Alone for Guiding Percutaneous Coronary Intervention in Native Coronary Lesions * Randomized Study.

The objective is to assess whether analysis of the initial coronary CTA datasets using AR technology would affect the PCI treatment strategy and its immediate results as compared to traditional PCI under angiographic guidance alone.

Restriction of dietary AGEs to prevent diabetes in overweight individuals: a randomized controlled trial

The objective of this project is to study the effects of low levels of dietary AGEs in overweight subjects on insulin sensitivity, *-cell function, micro- and macrovascular function, and gut microbiota. The obtained insights can be used to attenuate…

Novel transcatheter arterial embolization for treatment of knee osteoarthritis: a randomized sham-controlled clinical trial

The main objective is to assess whether transcatheter arterial embolization of neovessels in patients with symptomatic knee OA results in significant pain reduction after 4 months compared to sham treatment.We hypothesize that novel transcatheter…