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Allogeneic mesenchymal Stromal cells for Angiogenesis and neovascularization in no-option Ischemic Limbs

Primary Objective: To investigate whether intramuscular administration of allogeneic MSCs is safe and potentially effectiveSecondary Objective: To investigate the potential of various markers related to inflammation, angiogenesis, and…

BIoresorbable polymer-coated ORSIRO versus durable polymer-coated RESOLUTE ONYX stents [BIONYX]: A randomized Trial With stENT Evaluation in all-comers IV [TWENTE IV]

The aim of the study is to compare the outcome of the bioresorbable polymer coated stent (ORSIRO) and a new generation permanent polymer coated stent (RESOLUTE ONYX) in an allcomers patient population and non-inferiority setting.

Does Increasing Oxygen Nurture Your Symptomatic Ischemic Ulcer Sufficiently?

This study has been transitioned to CTIS with ID 2024-511743-26-00 check the CTIS register for the current data. Primary Objective: Major amputation rate after 12-months of follow-upSecondary Objectives: - Amputation-free survival- Health-related…

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Upadacitinib in Subjects with Giant Cell Arteritis. SELECT-GCA

This study has been transitioned to CTIS with ID 2023-505476-29-00 check the CTIS register for the current data. This study consists of two periods. The objective of Period 1 is to evaluate the efficacy of upadacitinib in combination with a 26-week…

A Randomised, Parallel, Double-Blind, Placebo-Controlled Phase 2b Study to Assess the Safety, Tolerability and Efficacy of AZD8233 Treatment in Participants with Hyperlipidaemia (SOLANO)

To assess the safety and tolerability of AZD8233 as compared with placebo in participants with hyperlipidaemia receiving maximally tolerated statin and/or ezetimibe therapy as defined by the investigator.

Tailoring P2Y12 Inhibiting Therapy in Patients requiring Oral Anticoagulation after undergoing Percutaneous Coronary Intervention: The Switching Anti-Platelet and Anti-Coagulant Therapy - 2 Study

The aim of this study is to assess the pharmacodynamic effects of different P2Y12 inhibiting therapy (clopdiogrel vs ticagrelor) in patients at high risk for HPR identified according to the ABCD-GENE score in PCI treated patients also requiring OAC…

The Effect of an Online Plant-Based Dietary Program on Cardiovascular Risk Factors in Persons with Type 2 Diabetes Mellitus: A Randomized Controlled Trial

Primary Objective:• To evaluate the effect of an online 12 week plant-based dietary program compared to usual diet on change in glycated hemoglobin and estimated relative CVD risk in persons with type 2 diabetes. Secondary Objective(s): • To…

Genotype-guided strategy for antithrombotic treatment versus conventional clopidogrel therapy in peripheral arterial disease.

This study has been transitioned to CTIS with ID 2024-518122-33-00 check the CTIS register for the current data. The primary aim of the GENPAD study is to evaluate the ability of genotype-guided antithrombotic treatment to reduce adverse clinical…

PeRcutaneous cOronary intervention of native Coronary arTery versus venous bypass graft in patients with prior cORonary artery bypass graft surgery - the PROCTOR trial

To compare the clinical and angiographic outcomes of a strategy of native vessel PCI with SVG PCI in patients with prior CABG presenting with SVG failure and a clinical indication for repeat revascularization, as determined by the local Heart Team.

PIONEER III: A Prospective Multicenter Global Randomized Controlled Trial Assessing the Safety and Efficacy of the BuMA Supreme* Biodegradable Drug Coated Coronary Stent System for Coronary Revascularization in Patients with Stable Coronary Artery Disease or Non-ST Segment Elevation Acute Coronary Syndromes.

The primary objective is to demonstrate the safety and efficacy of the BuMA DES in patients with functionally significant ischemia requiring percutaneous coronary intervention (PCI) with implantation of drug eluting stents for the treatment of…

The GORE VBX FORWARD Clinical Study: A Comparison of the GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis to Bare Metal Stenting for Patients with Complex Iliac Occlusive Disease

The primary objective of this trial is to demonstrate the superiority of the GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis for primary patency when compared to bare metal stenting for the treatment of patients with complex iliac occlusive…

A randomized, double-blind, placebo -controlled, multicenter trial, assessing the impact of inclisiran on major adverse cardiovascular events in participants with established cardiovascular disease (VICTORION-2 PREVENT)

This study has been transitioned to CTIS with ID 2024-510735-21-00 check the CTIS register for the current data. Study CKJX839B12302 is a pivotal Phase III study designed to test the hypothesis that treatment with inclisiran sodium 300 mg s.c.…

A randomized double-blind, placebo-controlled, multicenter trial assessing the impact of lipoprotein (a) lowering with pelacarsen (TQJ230) on major cardiovascular events in patients with established cardiovascular disease (CVD).

This study has been transitioned to CTIS with ID 2023-508292-37-00 check the CTIS register for the current data. The study has two primary objectives addressing the same scientific hypothesis: one in the full study population who is at a high risk…

A randomized placebo-controlled double-blind trial studying the effect of single antiplatelet therapy (clopidogrel) versus dual antiplatelet therapy (clopidogrel + aspirin) on the occurrence of atherothrombotic events following lower extremity peripheral transluminal angioplasty

To assess whether and to what extent dual therapy clopidogrel 75 mg/acetylsalicylic acid 80 mg daily is superior to monotherapy clopidogrel 75 mg daily, in reducing the combined endpoint all-cause death and cardiovascular adverse events after one-…

A randomized controlled trial evaluating the safety and efficacy of the endovascular treatment of subjects with stenotic or restenotic lesions of the common femoral artery with the Supera Vascular Mimetic Implant compared to surgical Common Femoral Artery Endarterectomy

The objective of this study is to evaluate the 12-month outcomes of stenting with the Supera Peripheral Stent System (Abbott Vascular) versus endarterectomy in symptomatic (Rutherford 2-4) atherosclerotic lesions in the common femoral artery (CFA) (…

Inhibition of Mast cell Activation in AtheroScleroTic lesions using an Anti-IgE antibody approach (MAST-trial)

This study has been transitioned to CTIS with ID 2024-513581-19-00 check the CTIS register for the current data. The primary objective is, to determine whether short term anti-IgE treatment with an anti-IgE monoclonal antibody (omalizumab) can limit…

Effectiveness of mindfulness-based stress reduction for improving quality of life in patients with cardiovascular disease: a randomised controlled trial

In the Happy Hart study we investigate whether adding this mindfulness program to the standard treatment of people with cardiovascular diseases leads to a better quality of life, better mental health and a healthier lifestyle compared to the…

Virtual Monoenergetic Imaging of the Lower Extremities Using Dual-Energy CT Angiography in Patients with Diabetes Mellitus: A Randomized Controlled Trial

Several observational studies have been published evaluating DECTA for imaging of the lower legs, comparing this technique with conventional CTA. However, to the best of our knowledge, no randomised controlled trial has been conducted comparing both…

Investigating the effect of the digital Patient Benefit Assessment Scale, a goals-based tool, on patient-centred outcomes in the healthcare process.

To measure the effect of the digital picture based Patient Benefit Assessment Scale on patient-centred outcomes regarding their health care process, the first eight domains of the factor health care process of the PPPC-R questionnaire (appendix 2)…

A first-in-human, randomized, double-blind, placebo-controlled, single and multiple ascending dose study to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of INS-3001 in healthy subjects and patients with moderate aortic valve stenosis

SAD PartIn this part we will investigate how safe the new compound INS-3001 is and how well it is tolerated when it is used by healthy participants.We will also investigate how quickly and to what extent INS-3001 is absorbed, transported, and…