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Dutch randomized trial comparing Ultrasound-accElerated Thrombolysis with standard dose Urokinase versus half dose Urokinase for thrombo-embolic infra-inguinal arterial disease (DUET II)

To demonstrate that the use of US-accelerated catheter-derived thrombolysis in patients with recently (less than 7 weeks) thrombosed infra-inguinal bypass grafts or native arteries with half the dose urokinase (50.000 IU/h) will significantly reduce…

Prophylaxis of venous thromboembolism in patients with a fracture of the lower extremity being treated conservatively with a below-knee plaster cast.

The purpose of this study is to determine the need for thromboprofylaxis in patients being treated in a below-knee plaster cast after trauma of a lower extremity and if there is, to assess if both of the two tested prophylactic treatments are suited…

Multi Center Clinical trial of endovascular treatment of acute ischemic stroke in the Netherlands.

The primary objective of this study is to estimate the effect of endovascular treatment on overall functional outcome after acute ischemic stroke of less than six hour duration, in patients with a symptomatic anterior circulation IAO. The secondary…

Prospective study to the Optimal duration of Compression Therapy As prevention of chronic Venous Insufficiency After deep venous thrombosis

ACT reduces the incidence of PTS after DVT. In the Dutch CBO-guidelines current therapy is adviced for 2 years after diagnosis because most PTS develops within 2 years after DVT, with a peak incidence in the first year.Some clinicians claim that one…

Individually tailored elastic compression therapy after deep venous thrombosis in relation to the incidence of post thrombotic syndrome, a randomized multicenter trial

To assess the costs and effects of tailoring the duration of elastic compression stocking (ECS) therapy after deep vein thrombosis (DVT) to individual patients needs.

EUropean Pharmacogenetics of AntiCoagulant Therapy trial

To determine whether a dosing algorithm containing genetic information increases the time within therapeutic INR range during anticoagulation therapy with phenprocoumon compared to a dosing regimen that does not contain this genetic information.…

EUropean Pharmacogenetics of AntiCoagulation Therapy trial

To determine whether a dosing algorithm containing genetic information increases the time within therapeutic INR range during anticoagulation therapy with acenocoumarol compared to a dosing regimen that does not contain this genetic information.…

Assessment of the WATCHMAN TM Device in Patients Unsuitable for Oral Anticoagulation (ASAP-TOO)

The primary objective of this study is to establish the safety and effectiveness of the WATCHMAN TM Left Atrial Appendage Closure (LAAC) Device including the post-implant medication regimen for subjects with non-valvular atrial fibrillation who are…

Hospitalization or Outpatient ManagEment of patients with Pulmonary Embolism: a randomized controlled trial - HOME-PE

Main safety objective: To demonstrate, in normotensive PE patients, that a strategy based on the HESTIA rule compared to a strategy based on the simplified PESI score is at least as safe as regards the 30-day-rate of adverse events (recurrent VTE,…