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Insulin-induced microvascular dilatation during a physiological stimulus - Studies in hypertension and obesity.

1 : Will the intake of a liquid meal lead to insulin-induced microvascular dilatation in healthy subjects? 2: Does meal composition (high fat meal vs. high carb meal) play a role in the occurence of insulin-induced microvascular dilatation in…

Modulation of the plasma volume compartment by aerobic exercise in women at risk for hypertensive reproductive complications

Primary objective:• To investigate whether physical exercise prior to pregnancy in formerly preeclamptic women results in a comparable improvement of vascular and endothelial functioning as in women who had an uneventful pregnancy.Secondary…

Local microvascular reactivity to Acetylcholine in patients with essential hypertension: possible interactions with the local renin-angiotensin system.

We aim to study the vasoactive effects of Acetylcholine (NO dependent) in hypertensive patients and normotensive participants. Second, the correlation between the vasoreactivity of Acetylcholine and Angiotensin II will be studied. Third, the…

Butyrate: effect of oral administration in patients with mild hypertension

The primary objective of this study is to assess the effect of oral butyrate on blood pressure. Secondary objectives are to assess the effect of oral butyrate on faecal and plasma SCFA levels, gut microbiome composition, diuresis, renin and…

Effects of aldosterone antagonism on microvascular function in obese individuals

Primary objectives:1. Is plasma aldosterone concentration associated with microvascular function, specifically insulin-mediated capillary recruitment, in obese subjects?2. Does mineralocorticoid receptor antagonism result in improvement of…