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External Vacuum Expansion: evaluation in breast reconstructive surgery

The primary effectiveness objective of this study is to determine whether breast reconstruction with fat grafting is more successful with the EVEBRA Device than a breast reconstruction with fat grafting without the EVEBRA.The primary safety…

Prehabilitation and rehabilitation in breast cancer surgery patients: a pilot study

The objectives of the BREHAB pilot study include both process and research objectives. Analysis of the process objectives will enable the feasibility of a larger RCT to be assessed. They focus on the feasibility of prehabilitation and rehabilitation…

the BREAST trial (the Breast Reconstruction with External pre-expansion and Autologous fat transfer vs Standard Therapy trial)

This study aims to determine the effectiveness of a new breast reconstruction technique: Autologous fat transfer (AFT). This technique combines the advantages of using the patients* own tissue (fat cells), while being minimally invasive compared to…

Non-inferiority in operation time when using 3D SPECT/CT imaging, compared to standard 2D imaging, during sentinel node procedure for breast cancer patients

PRIMARY QUESTIONDuring the sentinel node procedure in breast cancer patients, does a 3D SPECT/CT protocol not lead to a longer operation time to remove axillary sentinel nodes, compared to the 2D standard protocol?• H0: OK-time(SPECT/CT) - OK-time(…

Clinically node negative breast cancer patients undergoing breast conserving therapy: Sentinel lymph node procedure versus follow-up. A Dutch randomized controlled multicentre trial.

The objective of this study is to decrease the number of breast cancer patients receiving overtreatment of the axilla, in order to positively influence the axillary morbidity rate and quality of life. Therefore, we investigate whether the sentinel…

Ultrasound-guided erector spinae plane block versus paravertebral block in breast cancer patients undergoing mastectomy with immediate reconstruction - a non-inferiority trial.

The objective of this study is to assess the non-inferiority of analgesic efficacy of ESP vs PVB for patients undergoing unilateral mastectomy followed by immediate reconstruction.

Long-term results of two-stage breast reconstruction with polyurethane-covered versus textured implants: a prospective, multicenter randomized controlled trial

Primary Objective: to determine whether polyurethane covered silicone implants (PCI) give a different capsular contracture rate than textured silicone implants (TI) in two-stage implant breast reconstruction after mastectomy in women.Secondary…

Effects of discharge with drain in situ on the risk of infection after placement of a tissue expander.

The primary objective of the study is to objective if there is a greater risk of loss of the tissue expander due to infection if patients are discharged with a surgical drain in situ.

Seroma reduction and drain free mastectomy - SARA trial

To prove that omitting drains after mastectomy and flap fixation does not contribute to higher incidence of seroma formation and therefore reducing patient disutility such as seroma aspirations and visits to the outpatient clinic, as well as…

A randomized controlled trial testing hyaluronic acid spacer injection for skin toxicity reduction of Permanent Breast Seed Implant (PBSI)

The primary objective is to evaluate and report the effect of an injected hyaluronic acid spacer on the rate of telangiectasia following PBSI.

Three-Dimensional Ultrasound Volume Ratio for Improving Cosmetic Results in Breast Cancer Patients; TURACOS trial

The value of implementation and cost-efficacy of Tumor Volume / Breast Volume Ratio, as measured by Automated Breast Volume Scanner (ABVS), during the preoperative workup in breast cancer patients on 1) cosmetic result after BCS, and 2) surgical…