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Inguinal or Ilio-inguinal Lymphadenectomy for Patients With Metastatic Melanoma to Groin Lymph Nodes and no Evidence of Pelvic Disease on PET/CT Scan - A Randomised Phase III Trial (EAGLE FM)

This study aims to provide a more rational evidence base for appropriate management for metastatic melanoma in the groin LNs, through assessing the effect of the addition of ipsilateral pelvic lymphadenectomy on patient disease-free survival (DFS),…

Music Under Surgery In Children

The main objective of this study is to investigate whether a music intervention as complementary treatment is effective in reducing anxiety and distress around surgery. Secondary objectives are effects of music on pain, on preoperative anxiety, on…

A multicenter randomized controlled trial comparing long term scar quality after hydrosurgical versus conventional tangential excision of deep dermal burns

To assess and compare long term scar quality of deep dermal burns after debridement with hydrosurgical- and conventional tangential excision.

Closure after small skin incisions and excisions with a new closing system

compare the SoClose system with traditional skin wound closure with intracutaneous suturs of small skin excision on: cosmetics, wound healing, closing time, patient comfort and costs.

Wireless Micro Current Stimulation: adjunctive therapy for hard-to-heal chronic wounds * a double-blind, placebo controlled trial

Our aim is to determine whether Wireless Micro Current Stimulation accelerates wound healing in hard-to-heal chronic wounds as compared to standard wound care treatment by conducting a double-blind, placebo controlled trial.

A multicenter, multinational, randomized, controlled, open label study, performed in children with thermal burns, to evaluate the efficacy and safety of NexoBrid as compared to standard of care (SOC) treatment

To evaluate the safety and clinical benefit of NexoBrid in hospitalized children (0-18 years) with deep partial and/or full thickness thermal burns of 1-30% TBSA and to compare NexoBrid to standard of care (SOC).

Efficacy of Verapamil/ Verapamil-Kenacort injection versus Kenacort injection in Scar Treatment

Scar volume and POSAS score will be measured in the Verapamil group, these will be compared to the scar volume and POSAS score in the Kenacort+Verapamil group and the Kenacort group. In addition, complications/ adverse effects will be reported.

Effect of infrapatellar nerve block on chronic anterior knee pain after tibial nailing.

To study the effect of a nerve block of the infrapatellar nerve with local infiltration with lidocaine or saline on chronic anterior knee pain after tibial nailing.Secondairy objectives:- to measure knee pain on a VAS for eight different activities…

Remifentanil use for procedural sedation and analgesia in the emergency department

Answering the following questions:1. Main question: Is remifentanil a usefull medication for PSA in the emergency department?2. What is the recovery time of the patient when using fentanyl / propofol / remifentanil (time between last gift PSA…

The use of activated Platelet Rich Plasma (PRP) in human autologous fat transfer.

To objectify improvements in local skin quality and graft take by the addition of PRP.

Perforator based interposition flaps for sustainable release of scar contractures: a reliable, simple and versatile technique.

A randomised controlled multcenter trial is performed to evaluate the perforator-based interposition plasty in comparison to full thichness grafts for scar contracture releases.

A randomized clinical trial on the effectiveness, cost-effectiveness and quality of life of Flaminal® versus Flammazine® in the treatment of superficial and deep partial thickness burns.

To evaluate the effectiveness, cost-effectiveness and quality of life of Flaminal® versus Flammazine® in the treatment of superficial and deep partial thickness burns.

Effect of a Platelet Rich Plasma (PRP) injection on the outcome of chronic lateral epicondylitis.
A double blinded randomized controlled clinical trial.

The effectiveness of PRP treatment in patients suffering from chronic lateral epicondylitis is still ambiguous. Therefore we study PRP treatment in a double blind randomized controlled trial in a homogeny patient population with respect to duration…

The treatment of moderate to severe onychocryptosis with either a wedge resection with or without phenolization or partial nailmatrix resection with phenolization, a randomized controled trial.

The objectification of the most effective surgical treatment, in which three operationprocedures are compared.

Wireless Micro Current Stimulation: adjunctive therapy for acute and chronic wounds * a randomized controlled trial.

Our aim is to determine whether Wireless Micro Current Stimulation accelerates wound healing in chronic wounds as well as surgical wounds healing by secondary intention, as compared to standard treatment. Furthermore, by usage evaluation we intend…

Clinical Application of a Dermal Substitute based on glycerol
preserved Allograft: GLYADERM®
A multicentre, prospective, controlled, randomized, comparative
trial of Glyaderm® and split thickness skin graft versus split
thickness skin graft alone in full thickness skin defects

Objective: The main objective is to evaluate the difference in scar quality, after skin restoration of full thickness defects treated with Glyaderm® and STSG versus STSG alone.Secondary objectives are: to evaluate the percentage of Glyaderm® take…

Treatment of surgical scars in breast reduction with laser device, to prevent scar hypertrophy.

There are indications that early laser treatment of wounds can reduce scar formation. With the laser device the wound will be heated, which is thought to be responsible for a reduced inflammatory reaction and hence for a reduced scar formation. The…

A phase II study of ARA 290 as therapeutic strategy in no-option critical limb ischemia patients.

A proof of concept study to test whether ARA 290 improves wound healing and reduces neuropathic pain in no-option patients with CLI

A pilot randomized controlled trial comparing the effect of a percutaneous and lipofilling technique in patients with a secondary Dupuytren*s contracture with standard fasciectomy surgery on convalenscence, contracture correction and recurrence rate.

To compare treatment of secondary Dupuytren*s contracture by standard limited (dermo)fasciectomy and by the modified percutaneous release combined with fat grafting. We focus specifically on return to function and if applicable to return to work (…

Treatment of subcutaneous abdominal wound healing impairment after surgery without fascial dehiscence by Vacuum-Assisted Closure® (V.A.C. ® SAWHI-Study) versus standard conventional wound therapy

The primary objective of this multicenter, parallel design, prospective, randomized clinical trial, with repeated observations over time, is to compare the clinical, safety, and economic outcomes of V.A.C.® Therapy and SCWT based on an open…