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Effectiveness of Septoplasty

What is the effectiveness of septoplasty compared to a watchful waiting strategy in adults interms of health related quality of life and nasal passage? What is the relation between costs and effects of this procedure?Which patients benefit most from…

Safety and Performance of a Bioabsorbable Fluticasone Propionate-eluting sinus dressing
(SinuBand) in the Postoperative management of Functional Endoscopic Sinus Surgery in patients
with Chronic Rhinosinusitis

This study is designed to evaluate the safety and performance of SinuBand, a bioresorbablefluticasone propionate-eluting sinus dressing in the postoperative management of FESS in patientswith chronic rhinosinusitis. The study will collect both…

Lobectomy for the treatment of non-small cell lung cancer (NSCLC):
video-assisted minithoracotomy (VAMT) versus muscle-sparing thoracotomy (MST)

see K1

A randomized clinical trial of surgery or radiosurgery (stereotactic radiotherapy) in patients with stage IA non-small cell lung cancer who are fit to undergo primary resection

To compare the outcomes of stereotactic radiotherapy (experimental arm) with that following primary surgery (standard arm) in a prospective phase III trial.

The effect of duration of nonabsorbable nasal packing (merocel) soaked with oxytetracycline and hydrocortisone (terrracortril) in the post-operative management of functional endoscopic sinus surgery in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) on healing of the sinus cavity

The primary objective is to assess whether a 10-14 day Merocel with TC packing of the sinus is better than a one day Merocel with TC packing in the improvement of clinical and sinus parameters in patients with symmetrical CRSwNP following FESS. The…

Optimal postoperative Pain management After Lung surgery (OPtriAL): multi-centre randomised trial

The main objective is to compare regional continuous paravertebral block (PVB), single shot multi-level intercostal nerve block (ICNB) and thoracic epidural analgesia (TEA) as pain relief techniques in order to provide safe, effective and efficient…

Optimal postoperative chest tube and pain management in patients surgically treated for primary spontaneous pneumothorax; a randomized controlled trial.

Our objective is to compare the efficacy of early chest tube removal combined with single-shot PVB versus standard treatment (chest tube for at least 3 days and thoracic epidural analgesia (TEA)) after surgery for PSP. Efficacy is defined as proving…

EORTC randomized phase II study of pleurectomy/decortication preceded or followed by chemotherapy in patients with early stage malignant pleural mesothelioma.

To investigate the feasibility of immediate P/D followed by cisplatin/pemetrexed chemotherapy (or carboplatin/pemetrexed chemotherapy) or deferred P/D after cisplatin/pemetrexed chemotherapy (or carboplatin/pemetrexed chemotherapy) in patients with…

CO2-lasertonsillotomy versus tonsillectomy in adult patients; a multicenter randomized controlled trial

The purpose of this study is to evaluate the added value of CO2-laser tonsillotomy for tonsil related diseases.

Effects of STB* wound dressing on nasal wound healing after radiofrequent coblation of the inferior turbinate

In this study we will compare the therapeutic value of nasal saline irrigations only versus nasal saline irrigations combined with nasal application of STB* ointment in patients who received inferior turbinate coblation by radiofrequency (ITC-RF).…