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Immune monitoring to characterize T-cell responses of kidney transplant patients during co-stimulation blockade by belatacept

Here, we postulate that the balance between the effect of belatacept on regulatory T-cell function and the relative insensitivity of memory T-cells for belatacept leads to donor-specific alloreactivity. We plan to study the peripheral CD28-dependent…

Follow-up Protocol to the Double-Blind Parts A and B of the Phase II Opsona Study OPN305-102 (A Three-Part, Multi-Centre, Randomised, Double-Blind, Placebo-Controlled, Parallel-Group, Sequential Adaptive, Phase II Study to Evaluate the Safety, Tolerability and Efficacy of OPN-305, a Humanised Monoclonal Antibody that Blocks Toll-Like Receptor 2, in Renal Transplant Patients at High Risk of Delayed Graft Function)

To assess out to one-year the clinical status of patients who completed the double-blind part B of the 6-month study period in the Opsona phase II protocol (OPN305-102) by recording the following:• Incidence of biopsy-proven allograft rejection or…

A phase IV, blinded, randomized controlled trial to compare the effectiveness of low pressure pneumoperitoneum during laparoscopic donor nephrectomy to optimize the quality-of-recovery during the early post-operative phase

To investigate whether the use of low pressure pneumoperitoneum during laparoscopic donor nephrectomy improves the quality-of-recovery during the early post-operative phase as compared to the use of standard pressure pneumoperitoneum.

A randomized controlled trial comparing deep versus moderate neuromuscular block - in low pressure pneumoperitoneum - to optimize the surgical conditions during laparoscopic donor nephrectomy

To investigate whether the use of deep neuromuscular block improves surgical conditions in low pressure laparoscopic donor nephrectomy

Randomized Phase III trial comparing immediate versus deferred nephrectomy in
patients with synchronous metastatic renal cell carcinoma.
EORTC 30073 SURTIME

The principal objective of the trial is to investigate whether the sequence of the nephrectomy in patients who receive sunitinib has an effect on patient outcome.

Effect of deep neuromuscular block and variations in arterial PCO2 on the surgical rating scale, extubation conditions and postoperative conditions following reversal with sugammadex

To assess whether the implementation of a deep neuromuscular block (NMB) (PTC 1-2) combined with induction of relative hypocapnia creates optimal surgical conditions as measured by the surgeon (using the 5-point Leiden surgical rating scale) versus…

Catheterbased REnal SympatheCtomy for hypErteNsion after kidneyTranplantation

To test the efficacy of renal sympathetic denervation therapy with a special focus on preservation of renal allograft function.

A single centre, prospective, randomised, double-blind, placebo controlled,
sequential, dose-escalating phase I study to assess the safety and tolerability of intravenously infused single doses of OPN-305 in healthy subjects.

Primary : - to assess the safety and tolerability of a single ascending intravenous iv infused doses of OPN-305 in healthy subjects- determination of dose and infusion time for Phase II studiesSecondary : - to determine the pharmacokinetic profile…

Pilot Study of BB3 to Improve Renal Function in Patients with Signs and Symptoms of Significant Renal Injury after Kidney Transplantation from Donors after Cardiac Death

To evaluate the safety and activity of BB3 compared to placebo in improving renal function in the immediate post-transplant period in patientswho have received a DCD kidney transplantation.

Pilot Study of BB3 to Improve Renal Function in Patients with Signs and Symptoms of Significant Renal Injury after Kidney Transplantation from Donors after Cardiac Death.

To evaluate the safety and activity of BB3 compared to placebo in improving renal function in the immediate post-transplant period in patients who have received a DCD kidney transplantation.

A PROSPECTIVE RANDOMIZED STUDY ON THE EFFICACY AND SAFETY OF THE PROPHYLACTIC USE OF RITUXIMAB, ADDED TO STANDARD IMMUNOSUPPRESSIVE TREATMENT IN COMPARISON WITH STANDARD IMMUNOSUPPRESSIVE TREATMENT ALONE IN RENAL TRANSPLANTATION

To determine the effect of rituximab, when added to standard immunsuppressive therapy, on the incidence and severity of biopsy-confirmed acute rejection within the first six months after transplantation.

The effectiveness of deep versus moderate neuromuscular blockade
during laparoscopic donor nephrectomy in enhancing postoperative recovery.

To establish the relationship between the use of deep neuromuscular blockade (NMB) during laparoscopic donor nephrectomy (LDN) -with standard pressure pneumoperitoneum- and the early quality of recovery.

Omission of stent placement on ileal urinary conduit

To assess whether the omission of IOS placement in patients undergoing cystectomy and ileal urinary conduit results in a similar per patient event-free 30-day survival rate as compared to those who receive regular IOS placement.

Lymphadenectomy in urothelial carcinoma in the renal pelvis and ureter - A randomized international clinical trial on lymphadenectomy in urothelial carcinoma in the renal pelvis and ureter

Hypothesis: Complete lymphadenectomy during nephroureterectomy because of invasive urothelial carcinoma may reduce the incidence of lymph nodes metastasis, local recurrence, and distant metastasis and improve the cancer survival rate.Purpose: To…

Fasting before live kidney donation, effect on donor wellbeing and postoperative recovery

The primary objective is to determine the effect of nutritional preconditioning by fasting with a lowdose laxative on the severity of postoperative fatigue at 4 weeks after donor nephrectomy in adult patients.

A prospective study of primary metastatic renal cell carcinoma treated with immunecheckpoint inhibitors and cytoreductive nephrectomy vs primary tumour in place

The aim of this study is to investigate whether performing a cytoreductive nephrectomy has a beneficial effect on overall survival in patients with metastatic renal cancer receiving systemic therapy using immunocheckpoint inhibitors.

Fasting Intervention for children with Unilateral Renal Tumours to reduce Toxicity

to investigate the effect of a pre-operative fasting diet on post-operative recovery after renal tumour surgery

The IMAGE1 S* Non-Muscle-Invasive bladder cancer study:
A multicenter international randomized controlled study to compare the outcome using the IMAGE1 S* System versus White Light Imaging (WLI) during TURB of Non-Muscle-Invasive Bladder Cancer (NMIBC).

To compare the recurrence rate of tumor at 12 months following IMAGE1 S* assisted TURB (Arm A) with White Light Imaging only assisted TURB (Arm B) in patients with primary or recurrent non-muscle-invasive urothelial bladder cancer (NMIBC Ta/T1/CIS…

SUBLIME study: patient controlled sublingual sufentanil tablets versus intravenous morphine
to enhance the quality of recovery after laparoscopic donor nephrectomy.

To investigate if patient controlled sublingual sufentanil tablets as compared to patient controlled intravenous morphine lead to improved independent mobilization on postoperative day 1 after laparoscopic donor nephrectomy (LDN).

A phase 1, randomized, double blind, placebo-controlled, single and repeated ascending dose study to assess safety, tolerability and pharmacokinetics of ZW800-1 injected intravenously into healthy volunteers

Primary Objective- To determine safety and tolerability of a single dose of ZW800-1 in healthy volunteers.Secondary Objectives- To determine the pharmacokinetics of a single dose of ZW800-1 by measuring the fluorescence of blood and urine.- To…