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A phase III randomized study of preoperative radiotherapy plus surgery versus surgery alone for patients with retroperitoneal sarcoma (RPS)

To assess whether preoperative radiotherapy, as an adjunct to curative-intent surgery, improves the abdominal local recurrence-free survival.

Cryotherapy in the recovery of bursectomy for subacromial pain syndrome. A pragmatic randomized controlled trial.

The purpose of this study is to investigate the value of postoperative cryotherapy on subjective patients-reported pain; shoulder function and quality of life in patients operated for SAPS .

Trans rectus sheath preperitoneal mesh repair (TREPP) versus transinguinal preperitoneal procedure (TIPP) for inguinal hernia repair: a multi-center randomized controlled trial.

Reduce postoperative chronic pain after open inguinal hernia repair.

The efficacy of virtual reality on gait and stair descending in patients with an Anterior Cruciate Ligament reconstruction.

The aim of this study is to investigate the efficacy of virtual reality on gait and stair descending in patients with an Anterior Cruciate Ligament reconstruction.

A Phase 3, Randomized, Single-Blind, Controlled Trial of Topical Fibrocaps* in Intraoperative Surgical Haemostasis

Primary:The primary objective of the study is to demonstrate the superiority of Fibrocaps plus gelatin sponge, as compared to gelatin sponge alone, for achieving hemostasis in subjects undergoing spine, liver, vascular or soft tissue surgery, when…

A pilot study on the effectiveness of the echoguided Transversus Abdominis Plane block during inguinal hernia repair surgery.

-The objective of this study is to determine, whether the use of an perioperative echo guided unilateral TAP block has an superior effect on postoperative pain after open hernia inguinal repair compared to wound infiltration with a long acting local…

Suture Techniques to reduce the Incidence of The inCisional Hernia

Primary question• Which bite size should be used to close a midline incision to prevent incisional hernia?Secondary questions• Is there a difference in postoperative complications between the two patient groups?• Is there a difference in…

The evaluation of treatment after zone II flexor tendon repair: modified Kleinert versus controlled early active mobilisation, a pilot study

The aim of this pilot study is to analyse the effects of two different hand therapy treatments after flexor tendon repair. These two hand therapy treatments concern the active mobilization protocol of the Belfast regime and the passive mobilization…

A double-blind randomized controlled trial comparing PArietene self-fixing semi-Resorbable mesh with standard heavy-weight polypropylene mesh on chronic inguinal pAin DEvelopment

Primary:Does the implementation of a Parietene® self-fixing semi-resorbable mesh (Covidien-Sofradim) result in less chronic inguinal pain as compared to a standard polypropylene mesh (Marlex®; Bard) in the treatment of a inguinal hernia using the…

Comparison of wound closure in sternotomy scars: intracutaneous closure versus Steristrip-S

The aim of this study is 1. to compare scarformation in two different operative protocols in a prospective manner of children who undergo sternotomy because of cardiologic disease. 2. to differentioate scar pain from sternotomy pain. 3. to estimate…

Surgical Management of Deep Posterior Compartment Syndrome of the Leg

Compare two surgical techniques for treatment of posterior CECS.

The efficacy of Trigger Finger treatment: a randomised, controlled, prospective clinical multicenter trial.

We would like to investigate the efficiacy of the treatment of Trigger Fingers by means of a reliable, randomised, controlled, prospective multi-center trial at a large-scale with a long term follow-up. After completion of the trial we will be able…

Tilburg double blind randomised controlled trial comparing inguinal hernia correction with anterior approach via Lichtenstein or Polysoft.

To compare postoperative pain after anterior inguinal repair with mesh according to Lichtenstein or open repair with Polysoft® mesh

Pre-incisional bupivacaine infiltration trocarincions, reduction of postoperative pain?

The purpose of this study is to monitor whether preicncisional bupivacaine (bupivacaïne 0,5% with epinefrine 1:200.000), infiltration in trocarcincisions reduces postoperative wound pain.

Pre-injection analgesic effects of low-level laser/light therapy (LLLT) in preparation for third molar surgery

The aim of this study is to evaluate the analgesic effects of LLLT on maxillary and mandibular block pre-injection sites in patients scheduled for elective third molar removal.

A randomised, double blind clinical trial comparison the effect of a ultrasound-guided transversus abdominis plane (TAP) block and wound infiltration on postoperative pain (48h) for open inguinal hernia repair in day-care

The objective of this study is to determine, whether the use of an perioperative echo guided unilateral TAP block has an superior effect onpostoperative pain after open hernia inguinal repair compared to wound infiltration with a long acting local…

Clinical, microbiological and radiographical evaluation of implant surface decontamination using air polishing in the surgical treatment of peri-implantitis; a randomized controlled study

The primary objective of this randomized controlled trial is to compare the clinical effect of decontamination of the implant surface during the surgical treatment of peri-implantitis using air polishing or hand instruments. The secondary objective…

The Dangle Study

Primary objective parameter: to assess whether a no dangling protocol is non-inferior to a dangling protocol in terms of proportion of patients who experienced partial flaps loss which did not require another free lap procedure at six months after…

A randomized phase III study of neoadjuvant chemotherapy followed by surgery versus surgery alone for patients with High Risk RetroPeritoneal Sarcoma

This study has been transitioned to CTIS with ID 2023-505261-84-00 check the CTIS register for the current data. The primary objective of this study is to assess whether preoperative chemotherapy, as an adjunct to curative-intent surgery, improves…

Timing of inguinal hernia repair in premature infants: A randomized trial

The objective of this study is to determine whether early inguinal hernia repair (prior to discharge home) or late inguinal hernia repair (approximately 5 months after discharge home) is the safer surgical approach for premature infants who are…