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Comprehensive Cardiac CT versus Exercise Testing
in Suspected Coronary Artery Disease (CRESCENT II Trial)

The overall aim of the study is to demonstrate that a comprehensive cardiac CT examination improves the diagnostic workup of stable chest pain in terms of accuracy, efficiency and costs. In concrete terms, the purpose of this randomized controlled…

A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, SAFETY, TOLERABILITY AND PHARMACOKINETIC STUDY OF SINGLE INTRAVENOUS DOSES OF GNX-5086 IN HEALTHY SUBJECTS

The purpose of the study is to investigate to what extent GNX-5086 is tolerated. It will also be investigated how quickly and to what extent GNX-5086 is absorbed and eliminated from the body (this is called pharmacokinetics).

Comparison of the ABSORB TM Everolimus Eluting Bioresorbable Vascular Scaffold System With a Drug- Eluting Metal Stent (XienceTM) in Acute ST-Elevation Myocardial Infarction

The primary objective of this study is to assess the neointimal healing score (as evaluated by intra-coronary OFDI) in patients with STEMI and treated with Abbott Vascular ABSORB everolimus eluting bioresorbable vascular scaffold (BVS) at 6 months…

A RANDOMIZED, OPEN-LABEL, MULTI-CENTER, ACTIVE-CONTROLLED, PARALLEL GROUP STUDY TO DETERMINE THE EFFICACY AND SAFETY OF THE REG1 ANTICOAGULATION SYSTEM COMPARED TO BIVALIRUDIN IN PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION

Primary To determine the efficacy of REG1 compared to bivalirudin in patients with coronary artery disease (CAD) undergoing Percutaneous Coronary Intervention (PCI) for preventing the composite of death, nonfatal myocardial infarction, nonfatal…

The effects of on the rheologic properties and oxygen transport capacity of red blood cells processed by 3 different types of cell savers, and its effects on microcirculatory blood flow and tissue oxygenation in vivo

The objective of this study is to determine in vitro the rheologic and oxygen transport capacity of the washed blood processed by one of 3 different cell savers and to measure in vivo after retransfusion of this processed blood in the patient the…

Epidural anesthesia for OPCAB, a randomized comparison between general anesthesia alone or general anesthesia combined with high thoracic epidural anesthesia for off pump CABG

In the present study we will determine the effect of sympathetic blockade by TEA on major outcome parameters after off-pump CABG.

INcrease Of VAgal TonE in chronic Heart Failure (INOVATE-HF) - A randomized study to establish the safety and efficacy of Cardiofit for the treatment of subjects with heart failure and left ventricular dysfunction.
A pivotal trial to establish the long-term safety and efficacy of the cardiofit system.

To determine the efficacy and safety of the CardioFit system for the treatment of subjects with systolic heart failure who have failed to achieve symptom relief through standard evidence-based management per applicable guidelines.

Novel diagnostic test to improve cardiovascular disease risk reduction in subjects with type 2 diabetes, increasing cost effectiveness and quality of life.

The aim of this study is to answer the question: *Will the addition of the lipoprotein profile to the conventional diagnostics for dyslipidemia in T2D patients, lead to a better risk classification of CVD development?*. The improved risk…

Early mitral valve repair versus watchful waiting in asymptomatic patients with severe organic mitral regurgitation; a multicenter, randomised trial.

To compare early mitral valve repair versus watchful waiting.

Serial hybrid atrial fibrillation ablation

To assess if serial hybrid ablation for freedom of AF is superior to epicardial ablation alone in patients with (long-standing) persistent AF

Revascularization with paclitaxel-coated balloon angioplasty versus drug-eluting stenting in acute myocardial infarction - a randomized controlled trial

This randomized controlled trial is designed to prospectively assess the safety and efficacy of a CE-marked paclitaxel-eluting balloon only strategy versus third generation DES in the setting of a STEMI. This inferiority design serves to demonstrate…

Spinal Cord Stimulation to treat post-operative AF

See protocol page 19The primary objective is to determine the occurrence of post-operative AT/AF between the start of anesthesia and the first 5 days after CABG surgery in randomized groups, defined as patients in the SCS group and patient in the…

A Clinical Outcomes Study to Compare the Incidence of Major Adverse Cardiovascular Events in Subjects Presenting with Acute Coronary Syndrome Treated with Losmapimod Compared to Placebo (PM1116197, LATITUDE STUDY)
(Short title: LosmApimod To Inhibit p38 MAP kinase as a TherapeUtic target and moDify outcomes after an acute coronary syndromE (LATITUDE)-TIMI 60)

Primary: To evaluate the efficacy of oral losmapimod compared to placebo added to standard of care in subjects with ACS on the time to first occurrence of adjudicated MACE (defined as CV death, MI, or severe recurrent ischemia requiring urgent…

Finding the optimal treatment of severe panic symptoms in patients presenting at the emergency department with non-cardiac chest pain or palpitations. A cognitive behavioural therapy based intervention versus an information sheet. A randomized controlled trial.

The objective of our study is to examine the effectiveness of a cognitive behavioural therapy based intervention compared to an information leaflet on anxiety symptoms after one month, in patients presenting at the emergency unit with non-cardiac…

Comparison of Titanium-Nitride-Oxide coated Bio-Active-Stent (Optimax*) to the Drug (Everolimus) -Eluting Stent (Synergy*) in Acute Coronary Syndrome

The purpose of the trial is to compare the safety and effectiveness of bio-active-stent (BAS; Optimax*) and everolimus-eluting stent (EES; Synergy*) in patients presenting with acute coronary syndrome

Effects of polyphenol supplementation on inflammation and coronary endothelial function in patients with documented coronary artery disease

Primary Objective: The primary objective is to assess the effects of the oral administration of a daily dose of 1000 mg polyphenol extract for 3 weeks on biochemical markers of leucocyte recruitment in patients with documented CAD. Secondary…

Mindfulness-based cognitive therapy in female patients with microvascular coronary disease

To evaluate the efficacy of MBCT in comparison with treatment as usual (TAU) in women with MCDin terms of: reduction of psychological distress such as anxiety, depression and QOL, reduction of anginal symptoms, and improvement of vascular function

A Prospective, Randomized Evaluation of the TriGuard* HDH Embolic DEFLECTion Device during Transcatheter Aortic Valve Implantation

To assess the safety, efficacy, and performance of the TriGuard HDH embolic deflection device in patients undergoing transcatheter aortic valve implantation (TAVI), in comparison with patients undergoing unprotected TAVI.

Minimizing Adverse haemorrhagic events by TRansradial access site and systemic Implementation of angioX (MATRIX)

1) To demonstrate that trans-radial intervention as compared to femoral access site is associated to lower rate of the composite endpoint of death, MI or stroke within the first 30 days after randomization in acute coronary syndrome patients…

Evaluation of the Safety and Efficacy of Using Insulin-like Growth Factor-1 in Patients With a Heart Attack (RESUS-AMI)

The primary objective of the study will be to evaluate two low doses of a single intracoronary injection of rhIGF-1 compared with saline placebo on global LVEF by cardiac MRI and for safety (hypoglycaemia) in select subjects with STEMI and severe…