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The effect of Adenosine on Myocardial Protection in Intermittent warm blood Cardioplegia: a randomized placebo-controlled trial

The aim of this study is to determine whether the addition of adenosine to standard intermittent warm blood cardioplegia reduces the 6-hours post-operative cTnT in patients scheduled for minimally invasive, port access operations (mitral valve…

Comparison of a single dose fibrinogen with placebo and the number of blood transfusions after ascending aorta surgery (FIBTEG study)

The purpose of this study is to answer the following question: Leads a primary coagulation corrected with a single dose of fibrinogen concentrate after ascending aorta-arc reconstruction to a decrease in the number of allogenic blood transfusions,…

Preventing Oxidative stress-induced ischemic injury and systemic inflammation complications during and after invasive cardiac surgery with Alkaline Phosphatase (APPIRED III)

The purpose of this study (APPIRED III) is to investigate the efficacy of administered prophylactically RESCAP with regard to the prevention of (severe) renal failure, or renal dysfunction, reducing morbidity and mortality. It also looks at systemic…

Bicuspid aortic valve stenosis and the effect of vItamin K2 on calciummetabolism on 18F-NaF PET/MRI (BASIK2): a pilot study

To test the hypothesis that supplementation with vitamin K2 in comparison to placebo (total duration of treatment: 18 months) will slow down aortic valve calcium metabolism (on18F-NaF PET/MRI) after 6 months in subjects with a bicuspid aortic valve…

IcoSApent ethyL to slow down aortic VAlve stenosis proGrEssion

This study has been transitioned to CTIS with ID 2024-517342-33-01 check the CTIS register for the current data. The primary objective is:• to study the effect of icosapent ethyl on progression of aortic valve calcification.The secondary objectives…

Does colchicine reduce progression of aortic valve stenosis?

This study has been transitioned to CTIS with ID 2024-513486-39-00 check the CTIS register for the current data. The main objective of this study is to determine the effect of colchicine on the progression of moderate AS in asymptomatic patients.