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Internet-based vascular Riskfactor Intervention and Selfmanagement study

The objective of the proposed study is to evaluate the efficacy on risk factor management and toevaluate cost-effectiveness of an internet-based risk factor management program for patients at highcardiovascular risk.The research questions are…

Weanen ASV versus Pressure Support

to compare the difference in weaning by ASV and PC/PS

Clinical evaluation of Alpine® vs. Xpedition® stent delivery system of the XIENCE® everolimus-eluting stent

To evaluate and compare the procedural time of two stent delivery systems for PCI with EES.

Primary care decision rule for chest pain using the Marburg heart score rule and troponin point of care test

To determine the effectiveness of a decision rule compared to the usual care of GP*s for patients presenting with non-traumatic chest pain in primary care.

Cost-effectiveness of CYP2C19 genotype guided treatment with antipaletelet drugs in patients with ST-segment-elevation myocardial infarction undergoing immediate percutaneous coronary intervention with stent implantation: optimization of treatment.

To assess the efficacy, safety and cost-effectiveness of the CYP2C19 genotype guided antiplatelet treatment strategy, using clopidogrel or prasugrel/ticagrelor.

Ticagrelor or prasugrel versus clopidogrel in elderly patients with an acute coronary syndrome and a high bleeding risk: optimization of antiplatelet treatment in high-risk elderly

To assess the safety, efficacy and net clinical benefit of clopidogrel versus the new antiplatelet drugs i.e. ticagrelor and prasugrel in patients older than 70 years.

Hollands-midden Acute Regional Triage - cardiology (HART-c): point-of-care high-sensitivity cardiac Troponin I study

To determine the effectiveness of the HEART (History, Electrocardiogram (ECG), Age, Risk factors, Troponin) score with POC hs-cTnI testing by ambulance nurses in safely ruling out ACS and increasing the number of patients left at home after…