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A Randomised, Double-Blind, Placebo-Controlled Multicentre Clinical Trial of Inhaled Molgramostim in Autoimmune Pulmonary AlveoLAr Proteinosis Patients

The main purpose of this study is to investigate how molgramostim improves the flow of oxygen from the lungs to the blood in patients with aPAP. The effect on lung function as a whole will also be studied, along with any improvement in the patients…

A first-in-human, randomized, dose-Escalation, double-blind, placebo-controlled study to assess safety, tolerability and pharmacokinetics of APX001 administered by intravenous infusion to healthy subjects.

The study will be performed in 4 parts, Parts A, B, C and D. The purpose of the study is to investigate to what extent APX001 is tolerated.It will also be investigated how quickly and to what extent APX001 is absorbed and eliminated from the body (…

Hit hard and early. The effect of high dose methylprednisolon on nailfold capillary changes and biomarkers in early SSc: a 12-week randomised double-blind placebo-controlled trial.

Objective 1: analyze the effect of short-term treatment with high dose glucocorticoids on vasculopathic abnormalities as measured by NCM in patients with very early SSc.Objective 2: investigate the effects of glucocorticoids on signs and symptoms of…

Comparing Methotrexate monotherapy with methotrexate Plus LEflunomide combination ThErapy in Psoriatic Arthritis: A pragmatic randomized placebo-controlled double-blind clinical trial.

To compare the effectiveness of MTX monotherapy with MTX and LEF combination therapy in cDMARD-naïve psoriatic arthritis patients.

A PrOspective RandoMIsed Study of Treatment Selection Based on Epigenetic Markers Versus Standard of Care Treatment Selection in Adults With

Primary: To compare the efficacy of epigenome-guided treatment selection to usual standard of care (SOC) treatment selection for inducing clinical remission and endoscopic response at Week 26 in participants with active CD.Secondary:-To explore the…