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Immune monitoring to characterize T-cell responses of kidney transplant patients during co-stimulation blockade by belatacept

Here, we postulate that the balance between the effect of belatacept on regulatory T-cell function and the relative insensitivity of memory T-cells for belatacept leads to donor-specific alloreactivity. We plan to study the peripheral CD28-dependent…

Influence of BCG vaccine as a booster for TDaP-IPV vaccination

To examine the effect of BCG as an adjuvant on DTP vaccination, and to investigate the non-specific training effects of BCG and DTP, alone and in combination, on the innate immune system.

Mesenchymal stromal cell (MSC) transplantation in septic shock.

Evaluation of therapeutic safety and clinical efficacy of MSC transplantation in septic shock.

A RANDOMIZED, OPEN-LABEL, MULTICENTER TRIAL TO DETERMINE SAFETY AND EFFICACY OF ECULIZUMAB IN THE PREVENTION OF ANTIBODY MEDIATED REJECTION (AMR) IN LIVING DONOR KIDNEY TRANSPLANT RECIPIENTS REQUIRING DESENSITIZATION THERAPY

The objective of the study is to evaluate the safety and efficacy of eculizumab to prevent AMR in sensitized recipients of living donor kidney transplants requiring desensitization therapy.

Effects of orally administered Beta-Glucan on leukocyte function in humans, a pilot study

The primary objective of the study is to evaluate the systemic effects of orally administered Beta-glucan on innate immune responses of leukocytes. The effects of Beta-glucan will be determined by measuring the ex-vivo responsiveness of leukocytes…

Effects of oxygen status on Hypoxia Inducible Factor 1-α. A pilot proof of principle study.

The primary objective of the study is to determine the effects of hyperoxia and hypoxia in healthy volunteers on kinetics of HIF1α mRNA in circulating leukocytes. Secondary objectives are to determine the effects of hyperoxia and hypoxia on HIF1α…

A Randomized Open Label Study Comparing the Safety, Tolerability and Pharmacokinetics (PK) of Amantadine Hydrochloride and Ribavirin with Oseltamivir Phosphate (TCAD) Administered Orally Versus Oseltamivir alone Administered Orally to Influenza A Virus Infected Hospitalized Immunocompromised Patients

Primary: To determine the safety and tolerability of TCAD administered orally to immunocompromised patients diagnosed with influenza ASecondary: To assess the antiviral effect, the speed of symptom resolution, and the influenza complication rate of…

The effects of preceding human endotoxemia on the Fluenz-induced immune response, a explorative study

Our primary objective is to investigate the effects of endotoxin-induced systemic inflammation and subsequent development of endotoxin tolerance on the inflammatory response following Fluenz® administration in vivo. To evaluate whether these effects…

Immune protective anesthesia during endoscopic colon surgery to improve long-term survival

Main objective: 1. Is there a 24hr-postoperative difference in immunological response between conventional and immune protective anesthesia?Secondary objectives:Is there a difference between patients with conventional and immune protective…

The effects of human endotoxemia on the functional capacity of hematopoietic stem and progenitor cells

Primary objective: - To characterize hematopoietic progenitor cells in human bone marrow before and after endotoxemia (by evaluating hematopoietic lineage differentiation and functional capacity). Secondary Objectives: - To determine the effects of…

A Phase 3, Randomized, Open-Label, Multicenter Study, to Compare
T-Guard to Ruxolitinib for the Treatment of Patients with Grade III or IV Steroid-Refractory Acute Graft-Versus-Host Disease (SR-aGVHD)

To assess the rate of complete response (CR) in Grades III and IV SR-aGVHD participants on Day 28 postrandomization.

Safety and Performance Evaluation of Seraph 100 Microbind Affinity Blood Filter (Seraph 100) in the reduction of pathogen load from the blood in septic patients with suspected, life-threatening bloodstream infection.

The primary objectives are to demonstrate the safety and performance of the Exthera Medical Seraph 100 Microbind Affinity Blood Filter in the reduction of pathogen load from the blood in septic patients with suspected, life-threatening bloodstream…

Enhancing the BCG-induced trained immunity response by addition of bisphosphonate or MMR vaccine: a possible preventive approach against COVID-19 (BCG-PLUS)

To investigate the effect of bisphosphonates and the MMR vaccine on BCG-induced trained immunity as a possible preventive approach against COVID-19

AN OPEN-LABEL, RANDOMIZED, CONTROLLED, PHASE 2 STUDY TO EVALUATE THE SAFETY AND EFFICACY OF PEGCETACOPLAN IN THE TREATMENT OF POST-TRANSPLANT RECURRENCE OF C3G OR IC*MPGN

This study has been transitioned to CTIS with ID 2024-511544-36-00 check the CTIS register for the current data. Primary:To evaluate the efficacy of pegcetacoplan in improving the underlying pathophysiology of complement 3 glomerulopathy (C3G)/…

A Randomised Open-Label Trial of Early, Very High-Titre Convalescent Plasma Therapy in Clinically Vulnerable Individuals with Mild COVID-19

To determine whether convalescent plasma collected from donors who have recovered from COVID-19 and who have a very high titre of anti-SARS-CoV-2 antibodies reduce the risk of hospitalization or death due to COVID-19 in patients with early symptoms…

An open-label randomized controlled experimental endotoxemia study on the effects of the cytokine-adsorbing hemofilter CytoSorb on the development of immunoparalysis in humans

To determine the effects of the CytoSorb hemoperfusion column on the development of immunoparalysis in a repeated human endotoxemia model, which is reflected by attenuated plasma cytokine levels during the second LPS challenge.