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A Randomized, Double-blind, Placebo-controlled, Single Ascending Dose and Multiple Ascending Dose Study to Investigate the Safety, Tolerability, and Pharmacokinetics of REC-3964 in Healthy Subjects

REC-3964 is a new investigational drug, meaning that it has not yet been approved or marketed in the Netherlands or anywhere else at this time.In this study, REC-3964 is investigated in humans for the first time. REC-3964 has not been used by humans…

Pragmatic trial on the safety and tolerability of an optimized dose of rifampicin in tuberculosis patients

This study has been transitioned to CTIS with ID 2023-509885-39-00 check the CTIS register for the current data. The primary objective is to describe and compare the incidence of hepatotoxicity in standard care and in a regimen with an optimized…

Appropriate use of Blood Cultures in the emergency department through machine learning: a randomized controlled trial.

The aim of this study is to see whether we can safely use blood cultures more efficiently. By using a prediction model, we support the clinical decision to analyse a blood culture. If the chance that this culture yields a positive result is very…

*Primary and booster meningococcal vaccination in Dutch elderly: study to investigate the immune response and determine functional antibodies after the tetravalent MenACWY-TT conjugate vaccine in the elderly population*

This study has been transitioned to CTIS with ID 2024-513640-29-00 check the CTIS register for the current data. The aim of this study is to investigate the immune response to a primary and a booster immunization with a tetravalent MenACWY-TT…

Antibiotics vs antibiotics and Surgical ThERapy for Infective endocarditis

To test whether valve surgery plus medical therapy is superior to medical therapy alone for treatment of endocarditis.

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Analysing the immunogenicity of additional booster vaccinations in healthcare workers.
A multicenter, randomised, controlled trial

Key objective The key objective of the study to determine whether it is necessary to boost the healthy population in autumn. Primary endpoint: The primary endpoint is to determine the fold change in antibody level at day of boost and 28 days after…

Effectiveness of analgesic ear drops as add-on treatment to oral analgesics in children with acute otitis media: a pragmatic randomised controlled trial

To investigate whether analgesic ear drops added to usual care (oral analgesics with/without antibiotics) provide superior ear pain relief over usual care in children presenting to primary care with ear pain and diagnosed with AOM .

A randomized, blinded, placebo-controlled study to assess the safety, tolerability and pharmacokinetics of EGT710 following administration of single and multiple doses to healthy adults.

The purpose of the study is to see if the study compound (EGT710) is safe and tolerated when given to healthy adults. The study will also look at how the body absorbs, breaks down, and gets rid of the study treatment.Approximately 100 healthy…

A randomized, single-blind, placebo-controlled study to evaluate an oral cholera vaccination with intranasal rechallenge as adaptive immune challenge model

• To characterize the systemic response to mucosal immunization with an oral cholera vaccination challenge.• To characterize the local response to intranasal rechallenge after cholera vaccination as outcome measure for nasal mucosal immunity.• To…

A Phase 1b/2a, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate Nebulized Bacteriophage Treatment in Outpatient Adult Cystic Fibrosis (CF) Subjects with Chronic Pseudomonas aeruginosa (PsA) Pulmonary Infection

Primary Objective:To evaluate the safety and tolerability of nebulized BX004-A in CF subjects with chronic PsA pulmonary infection.Exploratory Objective:To evaluate the effect of BX004-A on sputum PsA burden, lung function, frequency of APEs, and…

Study into the effect of CytoSorb (cytokine adsorber) in relation to the MICrocirculation of patients with Septic Shock and Acute Kidney Injury at the ICU; MICSS-AKI

Could cytokines removal therapy by CytoSorb adsorber cause any improvement in the microcirculation?

A Dried blood spot sampling method for VANcomycin and Creatinine monitoring: Effectiveness Demonstrated in Outpatient Parenteral Antibiotic Therapy service

To investigate if dried blood spot sampling of vancomycin and creatinine leads to less outpatient visits regarding vancomycin therapy compared to conventional sampling in OPAT service.

Effectiveness of computerized training of attention and working memory in Post COVID-19 patients with cognitive complaints

Primary Objective: The aim of this study is to research the effect of a computerized cognitive rehabilitation program (RehaCom) in post COVID-19 patients with cognitive complaints on their sustained and divided attention and their working memory.…

Antibiotic prophylaxis for children with recurrent respiratory infections: towards evidence-based guidelines

Primary: To determine whether three months of prophylactic treatment with co-trimoxazole causes a reduction in the number of days a child experiences at least two RTI symptoms in children aged 6 months to <=10 years with recurrent RTIs, when…

Effect of intranasal administration of palivizumab on experimental respiratory syncytial viral infection - a controlled human infection study

Study A: Validation of productive infection of RSV CHIMStudy B: Effectiveness and immunogenicity of local administration of palivizumab on prevention of experimental RSV infection

Safe shortening of antibiotic treatment duration for complicated Staphylococcus aureus bacteremia

This study has been transitioned to CTIS with ID 2024-515398-90-01 check the CTIS register for the current data. To determine whether 4 weeks of total antibiotic treatment duration is non-inferior to 6 weeks in patients with complicated SAB who have…

A Randomised Open-Label Trial of Early, Very High-Titre Convalescent Plasma Therapy in Clinically Vulnerable Individuals with Mild COVID-19

To determine whether convalescent plasma collected from donors who have recovered from COVID-19 and who have a very high titre of anti-SARS-CoV-2 antibodies reduce the risk of hospitalization or death due to COVID-19 in patients with early symptoms…

Influencing Progression of Airway Disease in Primary Antibody Deficiency

This study has been transitioned to CTIS with ID 2024-513124-41-00 check the CTIS register for the current data. To show the protective value and to measure cost effectiveness of higher Ig dosing on progression of lung disease in PAD.

A randomized controlled trial on hypertonic saline inhalation in patients with nodular-bronchiectatic Mycobacterium avium complex pulmonary disease

To determine the effect of hypertonic saline inhalation and best supportive care versus best supportive care alone on clinical efficacy measures in patients with nodular-bronchiectatic M. avium complex pulmonary disease, as measured by changes in…

MRSA decolonization in complicated carriage - cluster randomized trial

To determine the superiority of doxycycline-rifampicin compared to trimethoprim-rifampicin for the decolonization treatment of complicated MRSA carriership.