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Game Ready continuous-flow cryo- and cyclic compression therapy after fracture treament of the hip: a prospective multicenter, open-label, multicenter, randomized, controlled, clinical trial on postoperative effects on pain.

The goal of the study is whether to establish if application of combined cyrocompression therapy directly postoperative after hip fracture surgery results in a significant reduction in painperception en whether this reduces the morfine consumption.…

The effect of Caphosol on the development of esophagitis in (N)SCLC patients treated with concurrent chemo/radiotherapy

Trial hypothesisAdding the use of Caphosol® (rinsing and swallowing four times a day) to the standard of care for esophagitis/mucositis, reduces the incidence, onset, duration and severity of esophagitis in (N)SCLC patients, comparing to the…

*Does maintaining endotracheal tube cuff pressures at 20 mm Hg prevent dysphagia and hoarseness after anterior cervical spine surgery?*
A randomised controlled trial.

To determine if adjusting endotracheal tube cuff pressure after placement of a retractor during anterior cervical spine surgery prevents postoperative dysphagia. Furthermore laryngo-tracheal complaints (hoarseness and sore throat) will be scored.

Decongestants for dilating the nasal cavity, a randomised, blinded, prospective study to prevent iatrogenic epistaxis during nasotracheal intubation

Primary Objective:The purpose of this study is to investigate the clinical efficacy of xylomethazoline, combined with dilating the nasal passage way with a polyvinyl-alcohol nasal dilator in the prevention of iatrogenic epistaxis during nasotracheal…

Local gentamicin in Redon treated post-sternotomy mediastinitis

The aim of our study is to evaluate clinical outcomes of patients primarily closed over Redon catheters for the treatment of PSM, comparing the application of local gentamicin with a control group.

Epiglottic downfolding during endotracheal intubation* An alternative technique to improve glottic exposure, and facilitate intubation?

We want to determine if epiglottic downfolding leads to a better view of the glottis and more successful intubations. We also want to investigate if this comes at the cost of more postoperative sore throat, dysphonia, dysphagia and coughing…

The analgesic efficacy of Δ9-THC (Namisol®) in patients with persistent postsurgical abdominal pain: a randomized, double-blinded, placebo-controlled, parallel design

Primary Objective: - To investigate the analgesic efficacy of a stable dose Namisol® in patients suffering from persistent postsurgical abdominal pain. Secondary Objectives:- To investigate the effect of a stable dose Namisol® on central nervous…

Does Misoprostol facilitate insertion of an Intra Uterine Device (IUD), both copper-containing as well as levonorgestrel-releasing, among nulli- and multipara?

To investigate whether Misoprostol (compared to placebo) will diminish the amount of insertion failures. To investigate whether Misoprostol (compared to placebo) will diminish the amount of insertion related complications (eg. syncope, perforation…

OTR4120: topical application to split-skin graft donor sites. A clinical evaluation on the healing.

Objective: To demonstrate the efficacy of a novel matrix therapy based technology that creates improved wound healing in a clinical donor site model.

Randomised controlled trial comparing the LFN (Lateral Femoral Nail) to the UFN (Unreamed Femoral Nail) in the treatment of femoral shaft fractures.

1 Confirm comparable results in reduction and consolidation of the fracture fragments using the LFN vs the UFN2 Identifying a significant difference in the soft tissue damage between the LFN and the UFN

Bile suppletion as adjuvant therapy in the treatment of iatrogenic bile duct injury after cholecystectomy: a bitter necessity?

The primary study objective is to investigate the contribution of peri-operative suppletion of bile to the preservation of bodyweight (expressed in kilograms).Secondary study objectives:1.To determine the contribution of peri-operative suppletion of…

Correction of Sub-clinical Prolongation of COAGulation Tests and/or Low Platelets before TRACHeotomy
- Randomized controlled trial *

To determine if patients with sub-clinical lengthening of coagulation test, low platelets or use of Ascal have increased risk of clinical significant bleeding during and after tracheotomy.

Chronic post-sternotomy pain, relation between accompanying painsymptoms and painlocation on the sternum

The objective of this study is to prove that chronic post-sternotomy pain is not a local painproblem, but part of a general painsyndrom.Our hypothesis is twofold:1. The investigated painsymptoms are of more frequently occurrence in the pain-sample…

Cosmo-Niveau
"Cosmetic results of choosing a different level of skin- and fascia-incision in a low transverse abdominal incision"

To determine whether there is any difference in the cosmetic result among women undergoing surgery for gynaecological diseases using two different lower transverse abdominal incisions: the Pfannenstiel incision versus a comparable technique in which…

Primary Closure of the lower limb and chest wound with Steri strip S in comparison with inter-cutane sutures in patients undergoing CABG.

To investigate whether application of Steri-Strip* S will lead to: 1) shorter treating time 2) improved satisfaction with the patient 3) improved wound healing4) improved cost-efficiency5) improved satisfaction with the attendant

Gauze throat at Oropharyngeal surgery

To investigate postoperative nausea and vomting in patients with or without a gauze throat after an operation of the mouth

A Randomized Controlled Trial on Prophylactic Platelet Transfusion Prior to Central Venous Catheter Placement in Patients with Thrombocytopenia

Our objective is to determine in a controlled study whether not correcting thrombocytopenia prior to CVC placement is non-inferior compared to correcting. In the Netherlands annually 17.700 units PC are possibly unnecessary transfused, for the…

PROtective ventilation with high versus low PEEP during one-lung ventilation for THORacic surgery - PROTHOR: A randomized controlled trial

To compare a strategy using high PEEP (10 cmH2O) with recruitment maneuvers versus low PEEP (5 cmH2O) without recruitment maneuvers, during thoracic surgery under standardized one lung ventilation with low VT (5 mL/kg predicted body weight - PBW) in…

CE marking for the Q-whet micro current wound stimulator

Objective:The objective of the study is to test the hypothesis that the QWHET micro current wound stimulation device has minimal side effects. The study will be designed as a double blind, prospective study.The results will be used to obtain a CE…