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TRANSANAL ENDOSCOPIC MICROSURGERY VERSUS ENDOSCOPIC MUCOSAL RESECTION FOR LARGE RECTAL ADENOMAS

In a randomized trial we will compare the cost-effectiveness and cost-utility of TEM and EMR for the resection of large rectal adenomas.

Prospective randomized trial to compare the clinical efficiency (Adenoma Detection Rate) of G-EYE(TM) HD Colonoscopy with Standard HD Colonoscopy

The aim of this study is to compare the additional diagnostic yield (adenoma detection rate) of G-EYE colonoscopy with that of standard high definition colonoscopy.

A Phase III Randomized Open-Label Study of Single Agent Pembrolizumab vs. Physicians' Choice of Single Agent Docetaxel, Paclitaxel, or Irinotecan in Subjects with Advanced/Metastatic Adenocarcinoma and Squamous Cell Carcinoma of the Esophagus that have Progressed after First-Line Standard Therapy (KEYNOTE-181)

Primary:1) To compare OS in subjects with squamous cell carcinoma of the Esophagus.2) To compare OS in subjects with PD-L1 Combined Positive Score (CPS)*10%3) To compare OS in all subjectsSecondary:1) To evaluate the progression free survival (PFS)…

Discovery: Pentax* Computer-aided Detection to Improve Adenoma Detection in a Real-time Setting - The Discovery II Study. A randomized clinical trial.

The primary objective of the study is to compare the ADR between PCSC and CC in patients referred for diagnostic, screening (non-iFOBT based) or surveillance colonoscopy.Secondary objectives are the following:- To compare the polyp detection rate (…

Randomized Two Arm Multi-Center Study to Evaluate the Safety and Efficacy of the Use of Magentiq Eye's Automatic Polyp Detection System (ME-APDS) During Colonoscopy

• Evaluate the safety of ME-APDS in subjects during colonoscopy.• Assess the efficacy of ME-APDS - whether the use of the ME-APDS improves the Adenoma Per Colonoscopy APC when compared to conventional colonoscopy (CC). Thereby we aim to further…

The European Polyp Surveillance study

1. To investigate the optimal time interval for colonoscopy surveillance in patients with low-risk and high-risk adenomas (EPoS I trial and EPoS II trial); 2. To evaluate the yield of surveillance in patients with clinically relevant serrated polyps…