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Comparison of adenoma miss rate and adenoma detection rates between Endocuff Vission-assisted colonoscopy and conventional colonoscopy: a multicenter randomized trial (EXCEED study)

(1) To compare adenoma miss rates (AMR) between Endocuff Vision-assisted colonoscopy (EAC) and conventionalcolonoscopy (CC)(2) To compare adenoma detection rates (ADR) between EAC and CC(3) To assess whether a proposed increased ADR and reduced AMR…

Semi-mechanical versus hand sewn cervical anastomosis after esophagectomy with gastric tube reconstruction for esophageal cancer; the SHARE study

The primary objective of this study is to compare a semi-mechanical with a hand sewn cervical anastomosis after esophagectomy with gastric tube reconstruction for cancer.

Gum chewing to prevent postoperative ileus after abdominal surgery; A multi-centre randomised single- blinded study.

In the Netherlands, gum chewing has not been incorporated in the standard postoperative care after intra-abdominal surgery. Therefore a multi-center RCT was set up to evaluate the influence of gum chewing on the development of ileus. Our null…

Single- vs. double-balloon enteroscopy in small bowel diagnostics: A randomized controlled single-blind multicenter trial

The primary aim of the present study is to compare the new SBE system with the standard DBE system with respect to completeness of visualisation and insertion depth of the small bowel, as well as complications during the procedure.

Bowel preparation for elective left-sided colonic surgery.

The objective of this study is to ascertain the best method of bowel preparation, prior to elective left-sided colonic surgery in terms of patient comfort and surgical efficacy. The occurrence of infections (wound, peritonitis) and anastomotic leaks…

Comparison of laparoscopic procedures with and without the aid the AutoLap system - a Robotic Camera Holder

The objective of this study is to evaluate the ability to reduce the number of OR personnel required while performing the following procedures: colon resections (right hemicolectomy, left hemicolectomy/sigmoid resection), anti-reflux/hiatal hernia…

A Multicenter Randomized Controlled Trial to Compare the Efficacy of End-ischemic Dual Hypothermic Oxygenated Perfusion with Standard Static Cold Storage of Liver Grafts Donated after Circulatory Death in Preventing Non-anastomotic Biliary Strictures after Transplantation

To study the efficacy of end-ischemic DHOPE in reducing the incidence of NAS within six months after controlled DCD (Maastricht category III) liver transplantation.

Stimulating fiber intake by personalized dietary advice

To investigate if a personalized dietary advice is more effective in increasing dietary fiber intake in the Dutch population than the general advice that is currently provided by the Netherlands Nutrition center and the Dutch Digestive Foundation (…

A Pivotal, Prospective, Randomized, Controlled, Multicenter Superiority Clinical Study Comparing Standard Anastomosis Closure Technique to Standard Closure Technique Plus Sylys Surgical Sealant.

- To evaluate the impact of the use of Sylys® Surgical Sealant as an adjunct to standard anastomosis closure techniques on anastomotic leak rate. - To evaluate the impact of the use of Sylys® Surgical Sealant on the overall number of anastomosis-…

Efficacy of online cognitive behavioral therapy on symptoms and quality of life with irritable bowel syndrome.

Primary objective:Is guided online treatment, based on CGT with mindfull- and exposure exercises, with minimal patient contact, effective for IBS-patients as compared to a waiting list?Secondary objectives: Will the guided online treatment lead to…

Hypothermic oxygenated perfusion (HOPE) of human liver grafts before transplantation - A multicenter, randomized controlled trial

The purpose of this study is, in a phase II randomized trial, to test a newly developed machine perfusion technique of human liver allografts before transplantation.

Multicenter, semi-blinded, randomized, controlled, parallel arms clinical study on the performance of SGM-101, a fluorochrome-labeled anti-carcinoembryonic antigen (CEA) monoclonal antibody, for the delineation of primary and recurrent tumor and metastases in patients undergoing curative surgery for colorectal cancer.

The primary objective of this clinical trial is to assess the performance of SGM-101 in theintraoperative detection of resection margins and metastases in patients undergoing curativesurgery for colorectal cancer. SGM-101 will be administered as a…