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Randomized controlled trial of escitalopram versus placebo for patients with irritable bowel syndrome and panic disorder.

PRIMARY OBJECTIVE· 1. To study the effect of escitalopram versus placebo in the treatment of abdominal pain, in IBS patients with panic disorder.SECONDARY OBJECTIVES· 2.1. To assess the effect of escitalopram on gastrointestinal and psychiatric…

A Multicentre, Randomised, Placebo-controlled, Double-blinded Study of the Efficacy, Safety, and Pharmacokinetics of Lubiprostone in Paediatric Subjects Aged * 6 Years to < 18 Years with Functional Constipation

To assess the efficacy, safety, and pharmacokinetics of oral lubiprostone 12 or 24 mcg capsules dosed twice daily (BID) (based on subject body weight at baseline) as compared to matching placebo BID, when administered orally for 12 weeks in…

Evaluation of changes in gut transit time and gastrointestinal symptoms following the consumption of a fiber containing product in adults with constipation.

The objective of this clinical trial is to evaluate the tolerance and effectiveness of 4 week supplementation of a proprietary polydextrose fiber product, in a dose-ranging fashion, on whole gut transit time and gastrointestinal symptoms in adults…

Trial consisting of an 8-week double-blind placebo-controlled part to evaluate efficacy, safety, tolerability and pharmacokinetics of prucalopride in paediatric subjects with functional constipation, aged ???6 months to &lt;18 years, followed by a 16-week open-label comparator (PEG) controlled part, to document safety and tolerability up to 24 weeks

The primary objective is to evaluate the efficacy of prucalopride compared to placebo for the treatment of functional constipation in a paediatric population, aged *6 months to &lt;18 years. Secondary objectives include:1. Investigation of the…

The effect of a multispecies probiotic on hypersensitivity in IBS patients

The effect of a specially developed multispecies probiotic on visceral perception, as well as on general symptom scores and inflammatory and microbiological parameters will be studied in a pilot study of IBS patients with an increased visceral…

A Multicenter, Randomized, Double-blind, Placebocontrolled, Parallel-group, Phase 2a Study of Oral IW-9179 Administered Once Daily for 14 Days to Patients with Functional Dyspepsia

The objectives of this study are to determine the safety and efficacy of IW-9179administered to patients with functional dyspepsia (FD), with and without concomitant protonpump inhibitor (PPI) administration.

A confirmatory, placebo-controlled, randomised, double-blind, single-dummy, parallel group, ratio-finding study in constipated pain patients to establish an optimal hydromorphone â¤* naloxone ratio with an improved bowel function and a comparable analgesic efficacy compared to hydromorphone alone

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A 12-week, randomised, double-blind, placebo-controlled trial to
evaluate the efficacy and safety of prucalopride in subjects with chronic
non-cancer pain suffering from opioid induced constipation

1. Primary objective:To evaluate the efficacy of prucalopride versus placebo over 12 weeks of treatment in subjects aged 18 years and older with chronic non-cancer pain, suffering from OIC.2. Secondary objectives:To assess the safety and…

A randomised, double-blind, active-controlled, double-dummy, parallel group study to determine the safety and efficacy of oxycodone / naloxone prolonged release tablets in subjects with moderate to severe, chronic cancer pain

To determine the improvement in symptoms of constipation in subjects receiving treatment with oxycodone/naloxone prolonged release tablets (OXN) compared to subjects receiving oxycodone prolonged release tablets (OXY) based on the Bowel Function…

An explorative, randomized, placebo-controlled, double-blind, parallel-group trial, to evaluate the pharmacodynamic effect of M0003 on reflux parameters in subjects with gastroesophageal reflux disease and with persistent symptoms despite taking a stable dose of proton pump inhibitors.

The objectives of this exploratory trial are:1. To measure the pharmacodynamic (PD) effect on parameters derived from 24-hpH/impedance (MII) monitoring,2. To explore the effect on symptoms,3. To evaluate the safety and tolerabilityof treatment with…

Double-blind randomised evaluation of clinical tolerance (taste) of PEG 4000 and PEG 3350 in children with constipation

Evaluate which PEG (4000 or 3350) is most preferred by children.Evaluate whether a preferable taste of the drug can lead to a better compliance and subsequently to a better success percentage of the treatment of childhood constipation.

Effect of droperidol 2,5 mg added to 100 mg morfine in PCA therapy in combination with ondansetron and dexamethasone against PONV.

The aim of the study is to investigate the surplus value of droperidol on top of het combination ondansetron and dexamethasone.

LEFTSTYLE advice for nocturnal reflux symptoms

The main objective of the study is to investigate if sleep positional therapy, using the LEFT, reduces nighttime gastroesophageal reflux symptoms.

Effect of citalopram on chest pain in patients with functional chest pain

To assess the effect of citalopram on symptoms of chest pain in patients with functional chest pain.

Perifere histamine 1 receptor blokkade in PDS

We want to examine the effect of the antihistamine Ebastine on abdominal pain and other symptoms associated with IBS and the quality of life. Through this research we would like to emphasize that this study primarily focuses on improvements of the…

The effect of galacto-oligosaccharides (GOS) or chicory fructo-oligosaccharides (FOS) versus a placebo on bowel habits in children with functional constipation.

In the present randomised double blind controlled study, we will study the effects of GOS or FOS vs a placebo on stool consistency. Other parameters to be investigated include stool frequency, stool consistency in number of cases (%), painful…

The effect of galacto-oligosaccharides (GOS) versus a placebo on defecation parameters and microbiota in healthy children with hard or lumpy stools

In the present randomised double blind controlled study, we will study the effects of GOS vs a placebo on stool consistency in children with hard or lumpy stools. Other parameters to be investigated include stool frequency, stool consistency in…

Multicentre, Randomised, Placebo-Controlled Trial of Mebeverine in Children with Irritable Bowel Syndrome (IBS) or Functional Abdominal Pain- Not Otherwise Specified (FAP-NOS)

The primary objective of this study is to determine the effect of mebeverine on abdominal pain intensity and frequency in children with irritable bowel syndrome or functional abdominal pain - not otherwise specified.

Double-blind, randomised, placebo-controlled, dose-finding phase IIb trial to evaluate the efficacy, safety, and tolerability of a 12-week-treatment with Naronapride in adult participants with at least moderate idiopathic or diabetic gastroparesis

This study has been transitioned to CTIS with ID 2023-510195-31-00 check the CTIS register for the current data. The study aim is to examine different doses of Naronapride film-coated tablets (for oral intake) versus placebo in patients with…

Benesco for reflux symptoms: efficacy and mechanism of action

to assess the effect of benescoTM on reflux symptoms (part A) and to evaluate the effect of benescoTM on esophageal sensitivity to acid and mucosal barrier function in subjects with reflux symptoms (part B).