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Randomized controlled trial of escitalopram versus placebo for patients with irritable bowel syndrome and panic disorder.

PRIMARY OBJECTIVE· 1. To study the effect of escitalopram versus placebo in the treatment of abdominal pain, in IBS patients with panic disorder.SECONDARY OBJECTIVES· 2.1. To assess the effect of escitalopram on gastrointestinal and psychiatric…

Cortrak bedside Or Regular Endoscopic placement of nasoenteral feeding tubes in surgical patients (CORE): a randomized controlled multicenter non-inferiority trial

To determine the (cost-)effectiveness and budget impact EM-guided bedside placement as compared to endoscopic placement of a nasoenteral feeding tube in surgical patients.

Individual or Group Hypnotherapy in the treatment of Irritable Bowel Syndrome in primary and secondary care.

This study has two main objectives:1. To assess the efficacy of hypnotherapy on symptoms and quality of life in IBS patients;2. To compare the efficacy of individual hypnotherapy with a group application of hypnotherapy in IBS treatment.

A Multicentre, Randomised, Placebo-controlled, Double-blinded Study of the Efficacy, Safety, and Pharmacokinetics of Lubiprostone in Paediatric Subjects Aged * 6 Years to < 18 Years with Functional Constipation

To assess the efficacy, safety, and pharmacokinetics of oral lubiprostone 12 or 24 mcg capsules dosed twice daily (BID) (based on subject body weight at baseline) as compared to matching placebo BID, when administered orally for 12 weeks in…

Evaluation of changes in gut transit time and gastrointestinal symptoms following the consumption of a fiber containing product in adults with constipation.

The objective of this clinical trial is to evaluate the tolerance and effectiveness of 4 week supplementation of a proprietary polydextrose fiber product, in a dose-ranging fashion, on whole gut transit time and gastrointestinal symptoms in adults…

Trial consisting of an 8-week double-blind placebo-controlled part to evaluate efficacy, safety, tolerability and pharmacokinetics of prucalopride in paediatric subjects with functional constipation, aged ???6 months to &lt;18 years, followed by a 16-week open-label comparator (PEG) controlled part, to document safety and tolerability up to 24 weeks

The primary objective is to evaluate the efficacy of prucalopride compared to placebo for the treatment of functional constipation in a paediatric population, aged *6 months to &lt;18 years. Secondary objectives include:1. Investigation of the…

The effect of a multispecies probiotic on hypersensitivity in IBS patients

The effect of a specially developed multispecies probiotic on visceral perception, as well as on general symptom scores and inflammatory and microbiological parameters will be studied in a pilot study of IBS patients with an increased visceral…

The effect of Gaviscon on acid reflux episodes and on the position of the gastric acid pocket: A Scintigraphic study

Earlier studies suggest that Gaviscon alters the position of the acid pocket, as the number of acid reflux episodes decreased but the number of nonacid reflux events almost doubled after drug intake. (8) However, until now the formation of the raft…

A multicenter randomized controlled trial of the effectiveness of pelvic physical therapy for children 5-17 years with functional constipation as SURPLUS to paediatric usual care

The purpose of this study is to investigate the effectiveness of pelvic physical therapy as a SURPLUS to the paediatric usual care in children (5-17 years) with functional constipation.Other research questions are: Does pelvic physiotherapy…

A Multicenter, Randomized, Double-blind, Placebocontrolled, Parallel-group, Phase 2a Study of Oral IW-9179 Administered Once Daily for 14 Days to Patients with Functional Dyspepsia

The objectives of this study are to determine the safety and efficacy of IW-9179administered to patients with functional dyspepsia (FD), with and without concomitant protonpump inhibitor (PPI) administration.

A confirmatory, placebo-controlled, randomised, double-blind, single-dummy, parallel group, ratio-finding study in constipated pain patients to establish an optimal hydromorphone â¤* naloxone ratio with an improved bowel function and a comparable analgesic efficacy compared to hydromorphone alone

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A 12-week, randomised, double-blind, placebo-controlled trial to
evaluate the efficacy and safety of prucalopride in subjects with chronic
non-cancer pain suffering from opioid induced constipation

1. Primary objective:To evaluate the efficacy of prucalopride versus placebo over 12 weeks of treatment in subjects aged 18 years and older with chronic non-cancer pain, suffering from OIC.2. Secondary objectives:To assess the safety and…

Pneumodilation Or Endoscopic Myotomy in Achalasia trial

To compare the efficacy of POEM to the efficacy of endoscopic pneumodilatation as the initial treatment of symptomatic idiopathic achalasia. The treatment succes is defined as symptom relief based on a Eckhardt score of 3 or less at 3 months, 1 year…

A randomised, double-blind, active-controlled, double-dummy, parallel group study to determine the safety and efficacy of oxycodone / naloxone prolonged release tablets in subjects with moderate to severe, chronic cancer pain

To determine the improvement in symptoms of constipation in subjects receiving treatment with oxycodone/naloxone prolonged release tablets (OXN) compared to subjects receiving oxycodone prolonged release tablets (OXY) based on the Bowel Function…

The cost effectiveness of tube feeding versus oral nutritional supplements
in hospitalized patients with IBD

The aim of the study is to assess the cost-effectiveness of implementation of tube feeding in hospitalized IBD patients.

A randomized controlled trial of physiotherapy in patients with fecal incontinence

This study is carried out to assess the effectiveness of rectal balloon training (RBT)combined with pelvic floor muscle training (PFMT) compared to pelvic floor muscle training alone in a population of patients with FI.

An explorative, randomized, placebo-controlled, double-blind, parallel-group trial, to evaluate the pharmacodynamic effect of M0003 on reflux parameters in subjects with gastroesophageal reflux disease and with persistent symptoms despite taking a stable dose of proton pump inhibitors.

The objectives of this exploratory trial are:1. To measure the pharmacodynamic (PD) effect on parameters derived from 24-hpH/impedance (MII) monitoring,2. To explore the effect on symptoms,3. To evaluate the safety and tolerabilityof treatment with…

Mindfulness-based stress reduction in patients with Irritable Bowel Syndrome (IBS)

the aim of the current pilot investigation is to examine the effectiveness of mindfulness based stress reduction in reducing stress levels in IBS patients, as well as the effects of the training on IBS symptom severity and quality of life in these…

Stimulation of the autonomic nervous system to improve postoperative recovery after colorectal surgery

To study the occurrence of postoperative ileus and the extend of the postoperative inflammatory response either systemic as well as locally in the bowel in patients receiving chewing gum before and after colorectal surgery.

Double-blind randomised evaluation of clinical tolerance (taste) of PEG 4000 and PEG 3350 in children with constipation

Evaluate which PEG (4000 or 3350) is most preferred by children.Evaluate whether a preferable taste of the drug can lead to a better compliance and subsequently to a better success percentage of the treatment of childhood constipation.