109 results
Objective: To compare patient outcome following standard of care (laparoscopic right hemicolectomy) and an alternative, established, recognized therapy (SILS right hemicolectomy) for the treatment of right colonic tumors.
The purpose of this research is to investigate the effect of early multimodal preconditioning for patients who will undergo esophaguscardiaresection will lead to improvement of cardiorespiratory fitness, nutritional status and quality of life. This…
The purpose of this project is to perform a randomized trial comparing BARRX ablation with endoscopic surveillance for patients with a Barrett*s esophagus containing low-grade dysplasia. This study will also assess the effect of RFA ablation in…
Primary objective:To determine the relationship of route of gastroenteric anastomosis after PD and postoperative incidence of DGE.Secondary objectives:To determine the relationship of route of gastroenteric anastomosis after PD and gastric emptying…
To evaluate efficacy and safety of regorafenib in patients with metastatic colorectal cancer (CRC) who have progressed after standard therapies.The primary efficacy endpoint of this study is * Overall survivalThe secondary efficacy endpoints of this…
To increase the amount of curatively treatable metastasis and recurrences of CRCandmaking an evidence-based guideline for the use of CEA in the follow-up of CRC
Goal is to use two non-invasive techniques (continuous cardiac output monitoring and impedance measurement) to investigate the possibility of cardiac output measurement and impedance measurement to reduce the fluid intake with 30% reduction while…
Through a non-invasive cardiac output measurement we want to investigate in this observational pilot study , if it is possible to reduce the fluid intake in the first 24 hours (both perioperatively and postoperatively) by 30 %
The aim of this study is to evaluate an intervention aimed at improving family disclosure of inherited cancer risks by 1) supporting counselees in what they experience as a necessary, but at times difficult, task and, consequently 2) provide more at…
Assessment of the detection of neoplastic lesions in patients with longstanding ulcerative colitis, using different endoscopic imaging techniques: A: Chromo-endoscopy, methylene blue 0.1% (HDTV Olympus)B: HDTV Olympus colonoscopes and NBIC: Chromo-…
The purpose of this clinical research study is to compare the effect of panitumumab to cetuximab (Erbitux®) in treating metastatic colorectal cancer in patients whose tumor contains the wild-type (unchanged) KRAS gene and who have previously been…
To investigate whether stem cell sparing radiotherapy results in a lower risk of dry-mouth syndrome than current standard treatment technique.
The primary objective is the safety and feasibility of CEA/frameshift derived neopeptide loaded DC in patient with MSI-positive colorectal cancer and persons who are known to be carrier of a germline MMR-gene mutation with no signs of disease yet.…
Optimalisation of the surgical treatment of esophageal cancer.
In this project we will evaluate the added value of PDT after complete EMR in patients with prior HGD and EC in Barrett*s esophagus.
The aim of the study is to develop a shorter, less technical demanding and therefore less uncomfortable for the patient, procedure for the HALO360 treatment of Barrett's esophagus with early neoplasie, high-grade or low-grade dysplasia, without…
1 Primary Objective To investigate the effects of 15* liver ischemia versus 30* liver ischemia on liver injury and liver function.To investigate the effect of liver manipulation during mobilisation for a right hemihepatectomy, that can be used as a…
Study goal is to answer the following question:Is there an effect of interactive education with a web-application on patient satisfaction for patients undergoing a colonic resection?Sub-questions are:1. Do patients with a higher education level have…
The purpose of this research is to investigate the effect and feasability of multimodal preconditioning for patients who will undergo esophaguscardiaresection.
The goal of this study is to prove that there is a benefit in terms of post-operative outcome not only because of the multi-modal improvements in peri-operative fluid management through the ERAS program, but also by the use of a goal-directed fluid…