Search for a trial

Laxatives postoperative colorectal surgery

The objective of this trial is to compare time to gastrointestinal recovery after elective colorectal surgery between patients treated with a laxative versus patients treated with a placebo.

A phase III randomized study evaluating surgery of residual disease in patients with metastatic gastro-intestinal stromal tumor responding to Imatinib mesylate.

The primary objective of this study is to evaluate whether surgery of residual disease in patients iwth advanced GIST responding to Imatinib improves the progression free survival.The secondary objective is to correlate the pharmacokinetics of…

Endoscopic Tri-Modality Imaging (ETMI) for the detection of early colorectal neoplasia; a multi-center randomized controlled trial

The aim of this randomized controlled multi-center study is to establish whether ETMI improves the detection early colorectal neoplasia compared to standard video endoscopy in a non-expert setting and is effective in differentiating neoplastic from…

Endoscopic Tri-Modal Imaging (ETMI) for the detection of early neoplasia in patients with Barrett*s esophagus (BE) in tertiary referral centers; a randomized cross-over multi-center study.

Does ETMI improve the dysplasia in Barrett's esophagus?

The effect of neoadjuvant treatment of colorectal cancer with simvastatin on the expression and activation of elements of the Bone Morphogenetic Protein pathway.

Does oral simvastatin at standard doses alter BMP pathway signalling in colorectal cancer specimens in humans?

Treatment of anal intraepithelial neoplasia in HIV-positive patients, a triple-arm randomized clinical trial

To establish the preferred treatment of AIN to prevent the development of severe anal neoplasia (persistent AIN III or anal carcinoma) in HIV+ MSM and HIV+ woman.

Three different limited bowel preparation regimes for CT colonography: evaluation of image quality and patient acceptance

To investigate what CTC iodine tagging-only bowel preparation gives a high image quality and readability of the CTC together with a high patient acceptance.

Chromoendoscopy in Lynch syndrome patients

The aim of this study is to determine whether chromoendoscopy, including polypectomy of all detected lesions, reduces the development of colorectal neoplasia in Lynch syndrome patients at follow-up endoscopy.

EXPAND (Erbitux in combination with Xeloda and cisplatine in advanced esophago-gastric cancer);Open-label, randomized, controlled, multicenter phase III study investigating cetuximab in combination with capecitabine (Xeloda, X) and cisplatin (P) versus XP alone as first-line treatment for subjects with advanced gastric adenocarcinoma including adenocarcinoma of the gastroesophageal junction.

To demonstrate superiority of XP chemotherapy regimen plus cetuximab versus XP alone asfirst-line treatment for advanced gastric cancer in terms of PFS. To assess cetuximab + XP versus XP alone with respect to: OS; overall response; QoL; safety.

A Randomized, Multicenter Phase 3 Study to Compare the Efficacy of Panitumumab in Combination with Chemotherapy to the Efficacy of Chemotherapy Alone in Patients with Previously Treated Metastatic Colorectal Cancer

The primary objective is to evaluate the treatment effect of P*mAb plus FOLFIRI on overall survival (OS) and progression-free survival (PFS) compared to FOLFIRI alone as second line therapy for metastatic colorectal cancer.

Enteral Nutritional strategies compared to reduce postoperative ileus after major colorectal surgery

The main objective of this clinical survey is to improve the nutritional status of patients undergoing major rectal surgery, thereby aiming to reduce postoperative ileus using the Bengmark a self-migrating nasojejunal tube and early enteral…

A randomized trial comparing radiofrequency ablation with step-wise radical endoscopic resection for treatment of Barrett*s esophagus with high-grade dysplasia or early cancer.

The purpose of this study is to find answers for the following questions:1. Is BARRX ablation a good alternative to step-wise radical endoscopic resection for patients with a Barrett*s esophagus with high-grade dysplasia or early cancer in terms of…

A double-blind, randomised, placebo controlled Phase III study of
nintedanib plus best supportive care (BSC) versus placebo plus BSC in
patients with colorectal cancer refractory to standard therapies.

The objective of this Phase III study is to evaluate the efficacy and safety of nintedanib in patients with mCRC after failure of previous treatment with standard chemotherapy and biological agents.

Percutaneous splachnic nerve neurolysis vs. endoscopic ultrasound-guided celiac ganglia neurolysis

To compare the efficacy of P-SNN to EUS-CGN with regard to decreasing chronic malignant pain in patients with inoperable intra-abdominal malignancies.

A Randomized Trial of Dose Escalation in definitive Chemoradiotherapy for patients with Oesophageal cancer *ART DECO*

To improve the local tumor control rate by escalating the radiation dose in definitive chemoradiotherapy for patients with locally irresectable or medically inoperable carcinoma of the esophagus or gastric junction without distant metastases (stage…

A Phase 3, Randomized, Placebo-controlled, Parallel-group, Multicenter, Double-blind Study to Evaluate the Efficacy and Safety of Telotristat Etiprate (LX1606) in Patients with Carcinoid Syndrome Not Adequately Controlled by Somatostatin Analog (SSA) Therapy

The primary objective of the study is to confirm that at least 1 or more doses of telotristat etiprate compared to placebo is effective in reducing the change from baseline in the number of daily bowel movements (BMs) averaged over the 12-week…

NUTritional Route In Esophageal resectioN Trial II

The aim of this study is to investigate the effects of early start versus delayed start of oral intake on postoperative recovery and pulmonary complications following esophagectomy. This is a non-inferiority trial.

Randomized controlled trial comparing the simplified and standard regimen for focal radiofrequency ablation

The aim of this study is the efficacy of a simplified triple regimen at an energy setting of 12 J/cm2 instead of 2x2x15 J/cm2, without a cleaning phase in between, and its effect on the rate of stenosis and overall complications when using the Barrx…

Multicenter randomized controlled trial comparing Ferric(III)carboxymaltose infusion with oral iron suppletion in the treatment of perioperative anemia in patients with a colorectal carcinoma.

The aim of this trial is to investigate which treatment option is superior in the treatment of anemia in patients undergoing surgery in terms of hemoglobin increase, postoperative morbidity, amount of bloodtransfusions needed, length of stay,…

A multicenter randomized phase III trial of neo-adjuvant chemotherapy followed by surgery and chemotherapy or by surgery and chemoradiotherapy in resectable gastric cancer (CRITICS-study: ChemoRadiotherapy after Induction chemoTherapy In Cancer of the Stomach).

This study investigates whether chemoradiotherapy (45 Gy in 5 weeks with daily cisplatin and capecitabine) after preoperative chemotherapy (3x ECC (epirubicin, cisplatin, capecitabine)) and adequate (D1+) surgery leads to improved survival in…