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PROGRESSIVE ESOPHAGEAL DILATION FOR BENIGN STRICTURES: A RANDOMIZED CONTROLLED TRIAL

The main objective is to compare the efficacy and safety of esophageal dilation with the balloon the Savary bougie dilator according to the rule-of-3 to rule-of > 3 strategy during 6 months in patients with a severe benign esophageal…

A RANDOMIZED COMPARISON OF DEGRADABLE ESOPHAGEAL STENT VS DILATION THERAPY: *DESTINY TRIAL* FOR PATIENTS WITH RECURRENT BENIGN ESOPHAGEAL STRICTURES

To compare the efficacy and safety of dilation of recurrent benign esophageal strictures by using a degradable self-expanding stent or standard dilation therapy.

Endoscopic Stenting versus Operative Intervention in Malignant Gastric Outlet Obstruction(STENTOP), a multi-center randomized controlled trial.

To investigate which treatment modality is preferable in patients with an irresectable malignant gastric outlet obstruction: endoscopic stent placement or a surgical gastrojejunostomy.

Clip-assisted duodenal feeding tube placement: a single blind, randomized controlled trial

To compare migration rate to the stomach or esophagus of clip-assisted endoscopic duodenal feeding tube placement with non clip-assisted endoscopic duodenal tube placement.

Randomized, single-blind, placebo controlled multicenter phase III study to assess the efficacy and safety of expanded autologous adipose-derived stem cells (eASCs) (CX-401), for treatment of complex perianal fistulas in Crohn*s disease.

The primary objective of the study is to evaluate the efficacy of intralesional administration of eASCs (CX-401) when added to standard surgical care and drainage for the treatment of complex perianal fistulas in patients with Crohn*s disease (CD).

A randomized comparison of a fully covered self expandable metal stent versus a partially covered self expandable metal stent in malignant esophageal strictures

To compare a fully covered metal stent versus a partially covered metal stent in patients with dysphagia due to an incurable malignant stenosis of the esophagus or cardia.

A multicenter, double blind placebo-controlled randomised trial for benign esophageal anastomotic strictures: Savary dilation vs savary dilation with triamcinolon

To compare Savary dilation with saline 0.9% injections (placebo) with Savary dilation with triamcinolon injections in patients with benign anastomotic esophageal strictures

A Multi-Center, Prospective, Randomized Study Comparing Removable, Self-Expanding Metal Stents to Plastic Stents for the Treatment of Benign Biliary Strictures Secondary to Chronic Pancreatitis

To compare the use of Self Expanding Metal Stents (SEMS) to plastic stents for the treatment of benign biliary strictures secondary to chronic pancreatitis as it pertains to stricture resolution rates, complication rates and number of ERCP…

A 12-week, randomised, double-blind, placebo-controlled trial to evaluate the efficacy, quality of life, safety and tolerability of prucalopride in male subjects with chronic constipation.

Primary: To evaluate the efficacy of prucalopride versus placebo over 12 weeks of treatment in male subjects with chronic constipation.Secondary: To evaluate the safety, tolerability, effect on quality of life and effect on symptoms of prucalopride…

Endoscopic Balloon Dilatation of stenotic ileocecal anastomosis in Crohn*s disease with or without additive local steroid injection and oral Budenofalk* a double-blind, randomized, parallel group trial

The primary objective of this study is to evaluate whether adding intensive local anti-inflammatory therapy (Triamcinolone injection therapy combined with 9 mg oral BudenoFalk once daily for 24 weeks) to routine enteric balloon dilatation reduces…

Laparoscopic pyloromyotomy (LPM) vs open pyloromyotomy (OPM) for hypertrophic pyloric stenosis:
Is there a difference in the postoperative reconvalescence and the immunological response?

The aim of this study is to compare LPM with OPM with respect to clinical benefits or disadvantages of LPM in children with hypertrophic pyloric stenosis.

Phase III multicentre, Randomised, Double Blind, Comparative study to assess the efficacy and safety of lanreotide 30mg versus placebo as a palliative treatment of clinical symptoms associated with intestinal obstruction due to peritoneal carcinomatosis in inoperable patients

Primary objective:The primary objective of this study is to assess the efficacy of lanreotide 30 mg as compared to placebo to relieve clinical symptoms due to small bowel obstruction in inoperable patients with peritoneal carcinomatosis.Secondary…

A Multi-Center, Prospective, Randomized (RCT) Study Comparing WallFlex® Esophageal Fully Covered (FC) Metal Stent to Bougie Dilation for the Treatment of Refractory Anastomotic Esophageal Strictures

To demonstrate that management of dysphagia for the treatment of refractory anastomotic esophageal strictures is more effective with Fully Covered metal stent than with Bougie Dilation.

Intensive endoscopic therapy versus conventional treatment for untreated benign anastomotic strictures after esophagectomy: a pilot and randomized controlled trial

To prolong the dysphagia-free period and to reduce the number of endoscopic dilations for patients with newly diagnosed, untreated benign anastomotic strictures after esophagectomy.

Intralesional steroid injections to prevent refractory strictures in patients with esophageal atresia - a randomized controlled trial

This study has been transitioned to CTIS with ID 2023-504905-36-00 check the CTIS register for the current data. The primary objective is to find out whether ISI in children with EA can prevent refractory strictures from developing and consequently…

Needle-knife incision therapy compared to usual care of recurrent gastroesophageal anastomotic strictures: a multicenter randomized controlled trial (SAMURAI-study)

The aim of the current study is to evaluate the efficacy and cost-effectiveness of NKI followed by EBD compared to standard EBD in patients with recurrent esophagogastric anastomotic strictures. The combination of NKI and EBD is estimated to achieve…

A prospective randomized multi-center study comparing endoscopic pneumodilation and per oral endoscopic myotomy (POEM) as treatment of idiopathic achalasia

This study is designed to evaluate which of the two treatment modalities results in the highest success rate after 2 years. Thereafter, follow-up will continue and a similar analysis will be performed 5 years after treatment (and every 5 years…

Endoscopic ultrasonography-guided gastroenterostomy versus surgical gastrojejunostomy for palliation of malignant gastric outlet obstruction (ENDURO-study)

Primary objective:to investigate and compare the effect of EUS-GE and SGJ on patients* short- and long-term ability to eat* (time to oral intake, and reinterventions for persistent or recurrent symptoms of GOO within 6 months of follow-up,…

Cola for Oesophageal Food Bolus Impaction (Cola Trial)

The objective of the study is to assess the efficacy and safety of cola as the initial treatment of complete oesophageal food bolus impactions.

Colonic stenting as bridge to surgery versus emergency surgery for management of acute left-sided malignant colonic obstruction: a multicenter randomized trial (Stent-in II study)

To compare colonic stenting followed by elective surgery with emergency surgery for the management of acute left-sided malignant colonic obstruction in terms of health-related quality of life, morbidity and mortality.