112 results
Primary Objective: To investigate in a prospective randomized controlled trial whether intravenous infusion of low doses dobutamine solely peroperative or for 18 more hours postoperative in women undergoing a breast reconstruction by means of a DIEP…
Primary objectives:- To evaluate the effect of old age (* 70 years) on everolimus pharmacokinetics (AUC0-24hr)- To evaluate the effect of obesity (BMI * 30 kg/m2) on everolimus pharmacokinetics (AUC0-24hr)Secondary objectives:- To evaluate whether…
Primary Objective: To examine the effects of equivalent weight loss with and without exercise on breast cancer biomarkers (endogenous sex hormones) in overweight, sedentary postmenopausal women.Secondary Objective(s): To examine the effects on body(…
A) Follow-up of breast cancer patientsPrimary research question1.In the follow-up of breast cancer patients: does a group medical consultation (GMC) increase patient empowerment compared to a regular individual visit and/or does it decrease…
Primary objective phase II:To explore if there is an indication of a positive effect on local control rate of adding Cisplatin to local reirradiation and hyperthermia to patients with local regional recurrent breast cancer in previously irradiated…
Objective of the study is to evaluate the different therapeutic options of lymphedema. Which treatment strategy is most cost-effective in the management of patients with breast cancer associated lymph edema: manual lymphatic drainage alone,…
To assess impact of high doses vitamin D on tumour histology in breast cancer patients
To determine the clinical efficacy and toxicity of ABT-869 in combination with paclitaxel in the first-line treatment of subjects with metastatic breast cancer.
This study will evaluate the efficacy of: a low intensity, home-based, self-management physical activity program, and a moderate intensity, structured, supervised exercise program, in maintaining or enhancing physical fitness (cardiorespiratory…
Nearly all patients who die from breast cancer die from the consequences of distant metastases. Adjuvant chemotherapy, either administered before or after surgery, has been shown to reduce the risk of metastases and death. Four main groups of…
An efficiency study will be conducted to evaluate the systematic use of the distress thermometer and its discussion by a nurse as compared to the usual care provided to outpatients who are treated for primary breast cancer by their treating…
The proposed study will focus on newly diagnosed breast cancer patients who, prior to receiving treatment, are identified on the basis of age or family history of breast or ovarian cancer as having at least a 10% risk of carrying a mutation in the…
The proposed study will evaluate the efficacy of a supportive intervention program in alleviating menopausal symptoms, improving sexual functioning and enhancing the quality of life of younger women (< 50 years) with breast cancer who have…
The proposed study will evaluate the efficacy of a supportive intervention program in alleviating menopausal symptoms, improving sexual functioning and enhancing the quality of life of younger women (< 50 years) with breast cancer who have…
The overall aim of the CASA trial is to investigate the role of PLD as adjuvantchemotherapy for older postmenopausal women for whom chemotherapy is indicated, but standard regimens, derived from trials in younger women, are assumed to be too toxic…
Primary Objectives:* To compare overall survival (OS) of patients who receive NKTR-102given once every 21 days (q21d) to patients who receive Treatment ofPhysician*s Choice (TPC) selected from the following list of seven singleagentintravenous…
To assess a pilot-study on the impact of removal versus preservation of the pectoral fascia on total drain volume, time to drain removal and needle aspirations (and thus seroma) in women undergoing bilateral prophylactic mastectomy.
Primary: The primary objective is to determine whether treatment with alpelisib in combination with fulvestrant prolongs progression free survival (PFS) compared to treatment with placebo in combination with fulvestrant based on local radiological…
The purpose of this study is to compare the effectiveness of treatment Arm A and Arm B by measuring the event free survival (EFS) and pathological complete response (pCR). EFS is defined as the time from the first treatment dose that the patient…
The major objectives of BENEFIT are (1) to explore the effect of exercise during neoadjuvant chemotherapy on the anti-tumoral chemotherapy effect, tolerability and compliance to chemotherapy, patient-reported outcomes including fatigue, sleep…