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Cancer@Work; a nurse-led web-based intervention to enhance the return-to-work of cancer survivors - a multi-center randomised controlled trial

To enhance sustainable return to work of cancer survivors of working age.

An open-label, randomized, Phase IIIb trial evaluating the efficacy and safety of standard of care +/- continuous bevacizumab treatment beyond progression of disease (PD) in patients with advanced non-squamous non-small cell lung cancer (NSCLC) after first (1st)-line treatment with bevacizumab plus a platinum doublet-containing chemotherapy

The main aim of this study is to find out if the continuation of bevacizumab, in addition to standard 2nd & 3rd -line treatment, can help patients with NSCLC that has progressed to live longer. The study also aims to find out if continued…

De-ESCALaTE HPV: Determination of Epidermal growth factor receptor-inhibitor (cetuximab) versus Standard Chemotherapy (cisplatin) early And Late Toxicity Events in Human Papillomavirus-positive oropharyngeal squamous cell carcinoma.

Primary objective: To compare the severe (acute and late) toxicity (Grade 3-5), as assessed by CTCAE Version 4, caused by cetuximab and RT to that caused by cisplatin and RT in patients with HPV+OPSCC.Secondary objectives:- Compare overall number of…

Couple therapy for cancer survivors : A prospective, randomized controlled study.

The primary objective of the study is to gain insight in the short term and long term effects of the EFCT-ODA therapy on 1) dyadic coping abilities in the relationship and 2) relational satisfaction. Moreover, the process aspects of the ODA will be…

A PHASE 1B/2 OPEN-LABEL STUDY TO EVALUATE SAFETY, CLINICAL ACTIVITY, PHARMACOKINETICS AND PHARMACODYNAMICS OF AVELUMAB* (MSB0010718C) IN COMBINATION WITH OTHER CANCER IMMUNOTHERAPIES IN PATIENTS WITH ADVANCED MALIGNANCIES

Primary Objectives* Phase 1b lead-in: To assess safety and tolerability of a single dose level of avelumab in combination withincreasing dose levels of other immune modulators in combination with a single doselevel of avelumab in patients with…

The efficacy of Sonographic and biological pleurodesis Indicators of Malignant Pleural Effusion (SIMPLE) - a randomised trial

This trial will prospectively test the use of ultrasound imaging and pleural fluid analysis in improving the management of patients with malignant pleural effusion.Primary objective: Establish if the use of TUS before and during the first 24-72…

A PHASE 1, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, SINGLE-DOSE ESCALATION, MULTIPLE-DOSE ESCALATION, AND FOOD EFFECT STUDY OF FLX475 IN HEALTHY MALE AND FEMALE SUBJECTS

The purpose of this study is to investigate how safe the new compound FLX475 is when it is administered to healthy subjects. FLX475 has not been administered to humans before. It has been previously tested in the laboratory and on animals. FLX475…

Anamorelin HCl in the Treatment of
Non-Small Cell Lung Cancer - Cachexia (NSCLC-C):
A Randomized, Double-Blind, Placebo-Controlled,
Multicenter, Phase III Study to Evaluate the
Safety and Efficacy of Anamorelin HCl
in Patients with NSCLC-C

Based on the data available, Anamorelin HCl produces an increase in total body weight and Lean Body Mass in patients with advanced cancer, and specifically in patients with NSCLC, in addition to increasing muscle strength and improving quality of…

The effectiveness and evaluation of the online 'Kanker Herstel Hulp' intervention in cancer survivors.

The project primarily aims to study short (3 and 6 months) and long term (12 months) health related effects of the 'Kanker Nazorg Wijzer' on survivors' psychosocial distress and quality of life (QoL). Furthermore, process aspects of…

The clinical relevance of axillary reverse mapping (ARM)

The objective of the study is to determine the clinical relevance of sparing the lymfdrainage of the upper extremitiy by using the ARM-procedure in patients with breast cancer. The purpose of the continuation of the feasibility study is to create a…

Treatment of Cancer in the Head and Neck:
The Role of Hyperbaric Oxygen in Reducing Swallowing Problems

Primary Study Objectives:This study tries to objectives the potential benefit of prophylactic HBOT in terms of reducing / limiting the amount of dysphagia and / or xerostomia for tumors in the head and neck, specifically originating from the…

Efficacy and Cost Efficacy of Prophylactic treatment with Antibiotics during concomitant chemoradiotherapy in patients with locally advanced head and neck cancer to prevent Aspiration Pneumonia. A randomized phase II-III study

To observe a decrease in number of definite and/or suspected pneumonia after prophylactic treatment with antibiotics during CRT in patients with LAHNC.To observe a decrease in the number of admissions in the hospital To observe a decrease in the…

A Randomized, Double-blind, Placebo-controlled Study to Evaluate the Long-term Safety and Efficacy of Darbepoetin Alfa Administered at 500 µg Once-Every-3-Weeks (Q3W) in Anemic Subjects With Advanced Stage Non-small Cell Lung Cancer Receiving Multi-cycle Chemotherapy.

The purpose of this study is to evaluate the safety of darbepoetin alfa, inclusive of the effects on survival and cancer progression, and the necessity of blood transfusions.

Early recognition and optimal treatment of delirium in patients with advanced cancer

In this study, we aim to improve recognition of delirium in a palliative care population with advancedcancer and we aim to provide evidence for optimal treatment of delirium through adequate dosing ofpreferred neuroleptic.Primary objectives:1) To…

The sword of Damocles. Managing fear of cancer recurrence with the SWORD intervention study (Survivors' Worries of Recurrent Disease).

Cognitive behavior therapy (CBT) seems a promising intervention to reduce FCR. The SWORD study (Survivors* Worries of Recurrent Disease) will examine the efficacy and cost-effectiveness of individual CBT compared to treatment as usual (TAU) in…

Web-based tailored information and support for patients with a neuroendocrine tumor: a randomized pilot study.

To detect whether a web-based tailored information and support system improves patients* perception and satisfaction of received information. We hypothesize that after having received web-based tailored information and support patients feel more…

Evaluation of the effect of psycho-oncological intervention on well-being of patients with advanced prostate cancer on LHRH analogs and their partners.
A randomized controlled pilot study.

To asses the feasibility of conducting a larger trial to evaluate the effect of a psychological intervention on well-being of patients on LHRH analogs in the treatment of prostate cancer and their partners.

Chromosomal instability as indicator for the treatment of progressive mucosal lesions of the oral cavity: a prospective study.

The aim of this prospective study is the prevention of progression of premalignant lesions to invasive head and neck cancer by modifying the out-patient follow up and patient management.

The effectiveness of a tailored intervention program on return-to-work in unemployed sick-listed cancer patients and survivors: A randomized controlled trial.

To evaluate the effectiveness of a tailored intervention program for unemployed sick-listed cancer patients and survivors on return-to-work, compared to care as usual.

A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Sequential Single Dose Escalation Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics and Effect of Food on Pharmacokinetics of CAL-120 in Healthy Male Subjects

Primary:to evaluate the safety and tolerability of single dose administration of the study drug in healthy male subjectsto determine the pharmacokinetic parameters following single dose administration of the study drug in healthy male subjectso…