79 results
Primary objective:1. Reduction of hospitality duration in patients with CAP treated with intravenous dexamethasone. Secondary objective:1. Reduction of the use of intravenous antibiotics in patients with CAP treated with intravenous dexamethasone.2…
Primary objective:To determine the relationship of route of gastroenteric anastomosis after PD and postoperative incidence of DGE.Secondary objectives:To determine the relationship of route of gastroenteric anastomosis after PD and gastric emptying…
Part 1:- To assess tolerability, safety and PK of escalating single Intravenous (IV) doses of NI-0101 in healthy volunteers with the aim of covering a wide range of plasma concentrations up to those theoretically reflecting a potential therapeutic…
To study if regular follow-up of PD patients with testing of their theoretical and practical knowledge (hereafter called *new type of follow-up*) can reduce the incidence of peritonitis, reduce the technique failure rate related to peritonitis, and…
To investigate the role of the gut microbiota in the systemic priming of immune effector cells during human endotoxemia
The primary objective is to compare the overall survival (OS; time from randomization to death) in patients with hepatocellular carcinoma (HCC) who had disease progression during or following sorafenib therapy, or were intolerant to this agent.…
The aim is to understand which individuals benefit from antibiotics.
Phase I- To characterize the safety and tolerability and determine the maximum tolerated dose of daily RAD001 in combination with daily sorafenibPhase II- To estimate the hazard ratio of the treatment effect as measure of anti-tumor activity of the…
1 Primary Objective To investigate the effects of 15* liver ischemia versus 30* liver ischemia on liver injury and liver function.To investigate the effect of liver manipulation during mobilisation for a right hemihepatectomy, that can be used as a…
To establish: 1) the effectiveness of adenoidectomy compared to a non-surgical strategy in children in terms of reduction of upper respiratory tract infections (with or without fever) and improvement in quality of life 2) the costs-effectiveness of…
The main objective of this study is to evaluate outcomes and resource needs of imaging and treatment following Primovist-enhanced MRI (PV-MRI) as com¬pared to ECCM-enhanced MRI (ECCM-MRI) and contrast-enhanced CT (CE-CT) in patients with a history…
To show the differrence of total healing of wound between two therapies, VAC and gauze-therapy, in patient with a sinu pilonidalis after chirgical intervention.
Primary Objective: • To determine the efficacy of 13vPnC in preventing a first episode of self-reported ILI.Secondary Objectives: • To determine the efficacy of 13vPnC in preventing a first episode of self-reported LRTI.• To determine the incidence…
Primary objective (parasitological): To induce protection against malaria by exposure to infectious mosquito bites under chloroquine prophylaxis. Secondary objectives (immunological): 1. To induce an effective immune response against natural malaria…
The primary objective of this study is to investigate whether application of PRF® will reduce postoperative wound leakage, the necessity for allogeneic blood transfusions and the incidence of wound healing disturbances in patients undergoing…
To prove the efficacy and safety of ethanol lock solution in preventing catheter-related infections and subsequently venous thrombosis in children with a malignant disease who will have a tunnelled central venous catheter inserted.
Aim of the study is to assess the effects of supplemental parenteral L-alanyl-L-glutamine treatment on infectious, cardiac, cerebral, pulmonary and gastro-intestinal morbidity during the ICU- (Intensive Care Unit) and hospital stay in patients after…
Primary: Investigate if sterile transparent dressing pasted on the skin before CVC insertion reduces the contamination risk of the CVC.Secondary: Investigate if direct contamination has a clinical significance.Investigate what the mayor…
The primary study objective is to compare the rate of major CIED infections through 12-months post-implant between the TYRX envelope group and the control group.
Primary:- To investigate efficacy of PCT-guided antibiotic therapy in the ED- To evaluate the safety of PCT-guided antibiotic therapy in the ED - To determine and compare the accuracy of PCT and CRP as biomarker for bacterial infectionSecondary:- To…