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A SYNDEMIC BASED LINKAGE TO CARE INTERVENTION FOR HIGH RISK MEN WHO HAVE SEX WITH MEN

Primary objective: Does a personalised behaviour intervention comprising of targeted in depth screening on mental health problems and drug use increase help seeking behaviour among MSM who are at high risk for STIs and HIV. Secondary objectives:…

Web-based attention bias modification treatment for childhood anxiety disorders: a randomized, double-blind, controlled trial

Specific AimsAs reviewed above, childhood anxiety disorders are highly prevalent and debilitating, and there is an urgent need for improvement of current treatment strategies. An innovative, but scarcely examined, treatment option for childhood…

From expecting to experiencing: The role of parenting cognitions in the transition to parenthood

Study 1 is aimed to describe normative trajectories of parenting efficacy from pregnancy to early parenthood. Study 2 is focused on the question whether mental representations of attachment are protective in the context of parenting stress and its…

Randomized controlled trial of escitalopram versus placebo for patients with irritable bowel syndrome and panic disorder.

PRIMARY OBJECTIVE· 1. To study the effect of escitalopram versus placebo in the treatment of abdominal pain, in IBS patients with panic disorder.SECONDARY OBJECTIVES· 2.1. To assess the effect of escitalopram on gastrointestinal and psychiatric…

Boosting Oxytocin after trauma: Neurobiology and the Development of Stress-related symptoms.

Primary aim:In recently traumatized individuals (at the latest on day ten post trauma exposure) with a high initial level of distress, we aim to assess the effectiveness of intranasal OT in preventing symptoms of PTSD at one months post intervention…

Cannabidiol enhancement of exposure therapy in treatment refractory patients with phobias.

The aim of this research project is to investigate cannabidiol as a new medicine to target the cannabinoid system in the reduction of anxiety disorder symptoms. The research question is whether cannabidiol, as an augmentation strategy of exposure…

Enhancement of exposure therapy for social anxiety disorder with testosterone: A randomized placebo controlled clinical trial

To investigate the efficacy of testosterone enhanced exposure therapy for social anxiety disorder.

A randomised comparison of Eye Movement Desensitization and Reprocessing (EMDR), Narrative Exposure Therapy (KIDNET) and waiting list control in traumatized refugee children.

The study aims to answer the following research questions:1. How high/low are levels of symptomatology of depression and/or PTSD in traumatised refugee children in ASC?2. Do symptom levels decrease after a short-term trauma-focused intervention?3.…

Multi-modular Motion-assisted Memory Desensitization and Reconsolidation (3MDR) as treatment for Posttraumatic Stress Disorder

This study is aimed at assessing the effect of 3MDR treatment as compared to treatment as usual (TAU) on PTSD symptom severity in treatment resistant veterans with chronic cr-PTSD. It is expected that 3MDR will give a boosting effect to TAU…

A Randomized, Placebocontrolled, Double blind, Single Ascending Dose Study to Investigate Safety and Tolerability, Pharmacokinetics and Pharmacodynamics of JNJ-61393215 in Healthy Subjects

The primary objectives of this study in healthy subjects are:- To investigate the safety and tolerability of JNJ-61393215 versus placebo after single oral dose administration under fasted (ascending dose levels) and fed condition.- To characterize…

Efficacy of EMDR Resource Development and Installation in the stabilization phase of treatment of complex posttraumatic stress disorder

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Cost-utility and cost-effectiveness of blended eHealth treatment for severe anxiety disorders in secondary mental health care

This cost-effectiveness study will compare blended cognitive behavioral treatment (bCBT) with standard face-to-face CBT (CBT-TAU) among patients with a diagnosis of an anxiety disorder referred to an outpatient specialized mental health care. The…

Is clinical DBT-PE the revolution we have all been waiting for in the treatment of victims of childhood sexual abuse?

The current study aims to replicate the Bohus study published in 2013, comparing the effect of a 12-week residential DBT-PE program on the severity of PTSD to that of a waiting list condition in patients who suffer from CSA related PTSD and from one…

The STAP-study: Skills training and traumafocused treatment in multiple interpersonal traumatized adolescents with PTSD.

The randomized controlled trial (RCT) will be performed at Karakter Child and Adolescent*s Psychiatric Hospital and will be implemented at all locations, spread out over three provinces in The Netherlands. The project aims:1. To explore the…

The effects of propranolol on fear of tooth removal: A randomized, placebo-controlled, double-blind, parallel design trial

The aim of this study is to determine the effects of propranolol on patients* crucial fear-related memories and dental trait anxiety in those undergoing surgical removal of one of their teeth or molars. The hypotheses that are tested are that…

Self-Esteem Treatment in Anxiety - positive versus negative memory representations

We want to answer the following research questions:- Which of the mentioned treatment approaches is more effective for improving self-esteem?- Do both approaches have additive value (does a patient benefit more after receiving both treatments, in…

Automatization and defamiliarization in Obsessive Compulsive Disorder

Primary objective 1: Does repeated relevant checking in general lead to automatization in OCD patients? Primary objective 2: If automatization as a result of repeated relevant checking occurs, do OCD patients differ from other anxiety disorder…

Body awareness training in the trEatment of Wearing-off related Anxiety in patients with paRkinson*s diseasE.

The current proposal aims at investigating the effect of a multidisciplinary non-verbal intervention on the awareness and modulation of WRA to improve self-efficacy, mobility, mood, and quality of life as compared to usual care.

A study on the effectiveness of the cognitive behavioral therapy "Seeking Safety" in reducing trauma and addiction related symptoms in a Dutch substance-use disorder population.

To test the effectiveness of the psychotherapy "Seeking Safety" in a Dutch SUD sample.

Towards a better trauma treatment for older adults:
From comparative research to actual implementation.

a. By this research a treatment protocol for NET will be quantitatively and qualitatively evaluated on its effects. b. With the research findings it is possible to identify subgroups within the research population and indicate who benefits most from…