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A prospective, double-blind, placebo-controlled trial investigating the efficacy and safety of Org 25935 in relapse prevention in subjects with alcohol dependence

Primary objective- To assess the effects of Org 25935 on heavy drinking in subjects with alcohol dependence.Secondary objectives- assess the effects of Org 25935 on the amount of drinking- To assess the effects of Org 25935 on the first relapse to…

The effect of caloric vestibular stimulation on disordered self-related cognition following psychotrauma and forced migration.

The objective of this pilot is to establish if CVS has any effect on patients with this psychogenic disorder in self-related cognition after psychotrauma and forced migration, and if so, to describe this effect in comparison with the effect CVS has…

Deep Brain Stimulation for patients with Tardive Dyskinesia and or Dystonia. Efficacy and Psychiatric and Cognitive Side-Effects

To assess whether treatment with DBS can reduce or resolve TDD and if DBS can induce beneficial or side effects in particular psychiatric and or cognitive symptoms.

A multisite randomized clinical trial evaluating BP1.3656 vs placebo for alcohol use disorder treatment.

The primary objective of this study is to assess tolerance and efficacy of 12 weeks BP1.3656 (30 µg or 60 µg OD versus placebo) to reduce alcohol consumption in alcohol dependent patients.

TMS-induced plasticity improving cognitive control in OCD

To characterise and compare neurobiological mechanisms underlying behavioural effects of three different rTMS treatment protocols in OCD using multimodal neuroimaging, with a focus on neuroplasticity.

A 3-Part, Randomized, Placebo-Controlled, Double-blind, Single Ascending Dose Study to Investigate
Safety and Tolerability, Pharmacokinetics and Pharmacodynamics of JNJ-55363932 in Healthy Participants.

Primary- To investigate the safety and tolerability of JNJ-55363932 after single oral dose administration(ascending dose levels) in healthy participants- To characterize the PK of JNJ-55363932 in plasma, cerebrospinal fluid (CSF) and urine…

Improving outcome through improving cognition in Severe Mental Illness: Cognitive Remediation Training combined with transcranial Direct Current Stimulation, a pilot study.

The primary goal is of this pilot study is to investigate the effects of Computerised Interactive Remediation of Cognition - a Training for Schizophrenia (CIRCuiTS), on the cognitive functioning of the described group of service users. It is…

*The Young Ones, an Acceptance and Commitment Therapy (ACT)-based transdiagnostic coaching group for young people with mental health problems*

We aim to evaluate the efficacy of an add-on trans-diagnostic ACT-group in adolescents (17-37 years), which is implemented in a mental institution in Amsterdam, the Netherlands.We hypothesize that there is a beneficial effect of an eight-week add-on…

Investigating a personalized smoking cessation treatment based on neurocognitive profile: an innovative deep cTBS study

The aim of the study is to investigate whether inhibition of the left or right insula has differential effects with regard to clinical outcomes (i.e. smoking cessation/reduction), cognitive processes (i.e. cognitive control, craving and goal-…