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The effectiveness of Pivotal Response Treatment in children and adolescents with autism spectrum disorder: a randomized clinical trail

Primary Objective: The main objective is to investigate the effectiveness of PRT compared to CAU in school-aged children and adolescents with ASD.The primary research question is:1) Directly after treatment and at follow-up, what is the…

Effectiveness of Cognitive Remediation Training (CRT) and vocational rehabilitation (IPS), in persons with early psychosis.

The present study focusses especially on the value of cognitive skill training within a program of work integration by means of IPS. Research shows that these interventions indeed lead to enhanced cognitive skills (Wykes et al. 2011). According to…

Evaluating social skills training in children with autism spectrum disorders: generalization of skills by training parents and teachers?

The current study aims to investigate the effectiveness of a social skills training for children with ASDs in the last two grades of primary education (10-12 years old). The first objective is to investigate the effectiveness as compared to no…

A prospective, double-blind, placebo-controlled trial investigating the efficacy and safety of Org 25935 in relapse prevention in subjects with alcohol dependence

Primary objective- To assess the effects of Org 25935 on heavy drinking in subjects with alcohol dependence.Secondary objectives- assess the effects of Org 25935 on the amount of drinking- To assess the effects of Org 25935 on the first relapse to…

Motivation study. Clinical empirical study on the effect of motivation feedback on motivation and compliance.

We want to study the effect of feedback to the clinician concerning the motivation of the patient to see if this feedback leads to a better motivation, compliance and treatment result because the clinician is more aware of the motivation (or the…

Effect of Routine Process Monitoring using the ORS / SRS scales on the outcome of treatment by a Rapid Response Team in MHC.

1. Currently, there are a wide variety of therapeutic techniques for specific patients and certain psychological problems. The guidelines on mental health care focus only on the specific therapy factors. In addition to these specific therapy factors…

SOS-training Social skills and Street skills: Improving strength and reducing vulnerability for victimisation: a randomised controlled trial in addicted patients with psychiatric disorders

The goal of this study is obtaining knowledge about the effectiveness of a training that aims to decrease victimisation of dual diagnosis patients.The primairy research question is:- What is the effect of the SOS-training on the frequency of…

Deep Brain Stimulation for patients with Tardive Dyskinesia and or Dystonia. Efficacy and Psychiatric and Cognitive Side-Effects

To assess whether treatment with DBS can reduce or resolve TDD and if DBS can induce beneficial or side effects in particular psychiatric and or cognitive symptoms.

A multisite randomized clinical trial evaluating BP1.3656 vs placebo for alcohol use disorder treatment.

The primary objective of this study is to assess tolerance and efficacy of 12 weeks BP1.3656 (30 µg or 60 µg OD versus placebo) to reduce alcohol consumption in alcohol dependent patients.

Families in the frontline;An evaluation study of parenting interventions for veteran families

The main objective is to investigate the effectiveness of parenting programs addressing family functioning and PTSD within the Dutch veteran population. A secundary objective is to unravel and identify the role of emotion regulation and…

TMS-induced plasticity improving cognitive control in OCD

To characterise and compare neurobiological mechanisms underlying behavioural effects of three different rTMS treatment protocols in OCD using multimodal neuroimaging, with a focus on neuroplasticity.

Suboxone (buprenorphine/naloxone) versus methadone opioid rotation in patients with escalated opioid use and chronic pain: a randomized trial.

This study has been transitioned to CTIS with ID 2024-513924-41-01 check the CTIS register for the current data. The primary objective of this study is to compare effectivity of suboxone and methadone on reducing opioid misuse.Secondary objectives…

Virtual reality therapy for voice hearing: a randomized controlled trial

To investigate whether VR-VOICES is more effective than regular treatment for voicehearing in patients with auditory hallucinations.

Repetitive Transcranial Magnetic Stimulation (rTMS) versus sham rTMS in
Body Dysmorphic Disorder

The main objective of this study is to investigate whether rTMS treatment will improve clinical outcomes in body dysmorphic disorder, by reducing BDD YBOCS outcomes. Furthermore to improve localization and rTMS treatment in the dorsolateral…

A 3-Part, Randomized, Placebo-Controlled, Double-blind, Single Ascending Dose Study to Investigate
Safety and Tolerability, Pharmacokinetics and Pharmacodynamics of JNJ-55363932 in Healthy Participants.

Primary- To investigate the safety and tolerability of JNJ-55363932 after single oral dose administration(ascending dose levels) in healthy participants- To characterize the PK of JNJ-55363932 in plasma, cerebrospinal fluid (CSF) and urine…

Forensic Network Coaching: a randomised controlled trial investigating the effectiveness of a network coach in improving mental well-being and decreasing psychiatric problems and criminal recidivism.

In this study we will examine the effectiveness and time course of the addition of a forensic network coach to treatment as usual in improving mental well-being among a forensic psychiatric outpatient population. Patients will be randomly allocated…

Improving outcome through improving cognition in Severe Mental Illness: Cognitive Remediation Training combined with transcranial Direct Current Stimulation, a pilot study.

The primary goal is of this pilot study is to investigate the effects of Computerised Interactive Remediation of Cognition - a Training for Schizophrenia (CIRCuiTS), on the cognitive functioning of the described group of service users. It is…

*The Young Ones, an Acceptance and Commitment Therapy (ACT)-based transdiagnostic coaching group for young people with mental health problems*

We aim to evaluate the efficacy of an add-on trans-diagnostic ACT-group in adolescents (17-37 years), which is implemented in a mental institution in Amsterdam, the Netherlands.We hypothesize that there is a beneficial effect of an eight-week add-on…

To what extent do veterans experience higher health-related wellbeing after adding the conversation model based on Huber*s concept on positive health to usual care?

Primary objective of this study is to gain insight in the effects of adding the conversation model according to positive health to usual care for veterans suffering from PTSD on patients* health-related wellbeing.

Sodium-oxybate as a potential new treatment for catatonia in patients with depression, bipolar disorder or a psychotic disorder, a randomized controlled trial. The Laborit study.

We aim to investigate whether sodium oxybate can be used as a novel treatment in psychiatric patients with catatonia. Our primary objective is: To determine if sodium oxybate is effective as a novel treatment in psychiatric patients with catatonia…