10 results
The objective of this study is threefold:1) compare the effectiveness and cost-effectiveness of brief CT added to maintenance AD versus maintenance AD alone versus guided tapering or discontinuation of AD with brief CT.2) examine whether the…
The purpose of this study is to develop a webbased intervention for breast cancer patients to reduce the impact of psychological problems that arise after the completion of medical treatment at an early stage. The question is whether this…
Primary:1. to investigate the serotonergic HPA-axis activation (cortisol, ACTH, prolactin) in patients with a major depressive episode, using a newly developed oral 5-HTP-challenge administered before the first ECT treatment.2. to investigate the…
The aim of the study is to:1. assess the prevalence of depression in patients with somatic illnesses admitted to the general hospital and to examine which self-report questionnaire is most suitable to screen for depression in this setting;2. to…
The overall objectives of the iSPOT-D trial are to use standardised genetic-brain-cognitionprotocols to:1. Identify markers of MDD as a diagnostic group and its subtypes2. Identify markers which change with acute (8 weeks) drug treatment in MDD3.…
Primary objective:To assess whether the state of premature immune aging (senescent CD8+ T cells) predicts treatment response to physical endurance intervention therapy in depressed patients. We will compare the mood-beneficial effects of physical…
Primary objective:To assess whether the state of premature immune ageing (senescent CD8+ T cells) modify treatment response to physical endurance intervention therapy in depressed patients. We will compare the mood-beneficial effects of physical…
Primary Objective:To evaluate feasibility, acceptability, effectiveness and cost-effectiveness of the culturally adapted PM+ intervention forSyrian refugees in The Netherlands.Secondary Objective(s):1. To translate and (culturally) adapt PM+ for use…
1. To prove that Short-Term Psychodynamic Psychotherapy (STPP) is in fact non-inferior to Cognitive Behavioural Therapy (CBT) in the treatment of Major Depression so it can be considered a treatment of first choice in the Dutch Guidelines for…
The main aim is to investigate efficacy of the Therap-i module, in addition to treatment-as-usual (TAU), in decreasing depressive symptoms in patients with MDD, who are unresponsive to protocolized psychological treatment for depression.