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Effectiveness of ultrasound imaging in general practice: optimising the management of patients with non-chronic shoulder complaints.

To optimize the management of non-chronic shoulder pain in primary care by the introduction of ultrasound as a diagnostic triage tool. The following research questions will be addressed:1. What are the effects of diagnostic ultrasound and its…

Results of subacromial surgery;
The influence of growth factors (PDGF), applied as autologous trombocyte concentrate, on functional recovery

test the hypothesis that the application of PRP leads to faster wound healing, less wound healing disorders, less pain and faster functional recovery after subacromial surgery.

A Clinical Study to Evaluate the Safety and Effectiveness of NOVOCART® 3D plus Compared to Microfracture in the Treatment of Articular Cartilage Defects of the Knee

Primary ObjectiveTo demonstrate that the effectiveness of the NOVOCART® 3D plus autologouschondrocyte transplantation system is superior to microfracture for the treatment ofarticular cartilage defects of the knee by demonstrating superiority of the…

The value of Platelet-Rich Plasma injections in the treatment of the jumper's knee: a double-blind randomised trial

There is a double study objective:- First the effects of a PRP-injection in the treatment of the jumper's knee in comparison with the effects of a placebo injection - Second the effects of a PRP-injection in comparison with the effects of an…

A randomised, double-blind, double-dummy, parallel-group multicentre study to demonstrate non-inferiority in pain and locomotor function and improvement in symptoms of constipation in subjects with moderate to severe pain due to osteoarthritis (OA) of the knee and/or hip taking oxycodone equivalent of 20 - 80 mg/day as oxycodone/naloxone prolonged release (OXN PR) compared to subjects taking oxycodone prolonged release tablets (OxyPR) alone.

• to assess opioid-induced constipation based on Complete Spontaneous Bowel Movement (CSBMs) recorded in the subject daily diaries during the first 4 weeks of the Double-blind Phase.• to assess the frequency of laxative use during the 12 weeks of…

A Double-blind, Randomized, Placebo-controlled Phase 3 Study of Orally Administered PLX3397 in Subjects with Pigmented Villonodular Synovitis or Giant Cell Tumor of the Tendon Sheath - ENLIVEN

The primary objective of this study is to compare the response rate of Pexidartinib with that of placebo per Response Evaluation Criteria in Solid Tumors, version 1.1 (RECIST 1.1) at Week 25 in subjects with symptomatic, locally advanced PVNS or GCT…

A Phase 3, Randomized, Double-blind, Placebo and Adalimumab-controlled Study to Evaluate the Efficacy and Safety of Filgotinib in Subjects with Active Psoriatic Arthritis Who Are Naïve to Biologic DMARD Therapy

The primary objective of this study is:* To evaluate the effect of filgotinib compared to placebo in active psoriatic arthritis (PsA) as assessed by the American College of Rheumatology 20% improvement (ACR20) response at Week 12Secondary objectives…

Effectiveness of blood flow restriction training after bone-patellar tendon-bone anterior cruciate ligament reconstruction: a randomized placebo-controlled trial

The purpose of this study is to evaluate the effect of low-load BFR therapy on quadriceps and hamstring strength 8-, 14-, 26-, 39- and 52-weeks after BPTB ACL reconstruction compared to placebo BFR therapy and conventional HLR training.

*Effectiveness of Ultrasound Guided Percutaneous treatment of Lateral Epicondylitis using standardized perforation with application of autologous blood, dextrose or perforation only, in relation to pain and functional recovery; A randomized controlled trial *

To assess the effectiveness of perforation and different injection therapies (autologous blood and dextrose) in the treatment of Lateral Epicondylitis of the elbow. The primary objective of our study is examining the change in pain score in the…

The effect of virtual reality on anxiety and pain in anterior cruciate ligament reconstruction: a prospective randomized controlled trial

The aim of this study is to determine whether VR used in the pre- and postoperative period after elective orthopedic surgery will decrease pain scores.

A randomized, double-blind, placebo-controlled, Phase III trial to
evaluate the efficacy and safety of intra-articular injections of
RTX-GRT7039 in adult subjects with pain associated with osteoarthritis of the knee

Primary objective:Demonstrate the analgesic efficacy of intra-articular RTX-GRT7039 compared with placebo.Secondary objective:• Demonstrate the analgesic efficacy of intra-articular RTX-GRT7039 compared with placebo.• Demonstrate the efficacy of…

MRI-BASED GRAFT MATURITY AFTER BLOOD FLOW RESTRICTION TRAINING IN BONE-PATELLAR TENDON-BONE ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION:
A RANDOMIZED CONTROLLED STUDY

Primary objective: The effect of LL-BFRT on MRI-based graft maturity after BPTB ACL reconstruction compared to HLRT.Secondary objectives: The effect of LL-BFRT on donor-site morbidity, range of motion, knee stability, PROMs, muscle strength, safe…