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Post-operative RadioTherapy for patients with metastases of the long bones

The OPTIMAL-PORT study aims to demonstrate the non-inferiority of *surgery only* compared to surgery with adjuvant radiotherapy as treatment for impending and actual pathological fractures on the pain experienced by patients.

Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY): A Multi-Center Randomized Controlled Study Comparing Alternative Antibiotic Regimens in Patients Undergoing Tumor Resections with Endoprosthetic Replacements

The objective of this study is to determine whether long term (5 days) postoperative (cefazolin) antibiotics will decrease the rate of infection following lower extremity tumor surgery, when compared to short term (24 hours) postoperative (cefazolin…

Maintenance therapy with trabectedin versus observation after first line treatment with doxorubicin of patients with advanced or metastatic soft tissue sarcoma

The main objective of the trial is to evaluate whether maintenance trabectedin given after 6 cycles of doxorubicin first-line therapy for advanced or metastatic STS prolongs progression-free survival (PFS) as compared to an observational approach.…

International Randomised Controlled Trial for the Treatment of Newly Diagnosed Ewing's Sarcoma Family of Tumours

The objective of the induction/consolidation chemotherapy randomisation (R1) is to compare: - VIDE strategy: vincristine, ifosfamide, doxorubicin and etoposide (VIDE) as induction chemotherapy and vincristine, actinomycin D and ifosfamide (VAI),…