Search for a trial

Effectiveness of continuous glucose monitoring during diabetic pregnancy

In the present proposal, we aim to assess the cost-effectiveness of the use of CGMS in diabetic pregnancies.

Novel diagnostic test to improve cardiovascular disease risk reduction in subjects with type 2 diabetes, increasing cost effectiveness and quality of life.

The aim of this study is to answer the question: *Will the addition of the lipoprotein profile to the conventional diagnostics for dyslipidemia in T2D patients, lead to a better risk classification of CVD development?*. The improved risk…

The effect of continuous glucose monitoring on glycaemic control in patients undergoing major surgery

Our objectives are to evaluate whether CGM improves perioperative glycaemic control.

Effect of Spinal Cord Stimulation in Painful Diabetic Polyneuropathy: a multicenter Randomised Controlled Trial (PDP study)

The primary objective of this study is to investigate whether SCS combined with best (drug) treatment as usual (TAU) leads to clinically significant (>=50%) pain relief in patients suffering from moderate-to-severe PDP in the lower limbs…

The effects of 4 weeks oral administration of omega-3 fatty acids on hepatic steatosis and insulin sensitivity in morbidly obese patients undergoing gastric bypass surgery.

The aim of this study is to evaluate the effect of supplementation of a high oral dose of omega-3 fatty acids on hepatic steatosis and glucose metabolism in morbidly obese patients undergoing laparoscopic Roux-Y gastric bypass surgery (LRYGBP).

A Phase 2, Multicenter, Randomized, Active-Controlled, Parallel-Group, Dose-Finding and Safety Study of Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2)/Calcium Phosphate Matrix (CPM) in Subjects With Decreased Bone Mineral Density.

Onset of effect of systemic therapy to enhance bone density (eg, bisphosphonates) is not immediate and may not adequately protect subjects with decreased bone density from fracture.Bisphosphonate therapy will typically require 2 to 3 years of active…

Increasing habitual physical activity to reduce the surgical risk of hyperglycemia and complications in patients with the metabolic syndrome

In the POSitive project we aim to investigate whether the diagnosis of the metabolic syndrome could be embedded in the clinical practice of the POS. The use of the POS clinic as screening platform for health prevention contributes to early case…

Efficiency of the Nutrimanager in screening and treatment of (risk of) disease-related malnutrition in the preoperative period in colorectal cancer patients.

Questions and hypotheses:Question (s) - Will the dietitian's knowledge of the patient's nutritional intake improve by using Nutrimanager.- Is there a stable or improved nutritional state in patients using the Nutrimanager compared tot…

Effect of transient high blood glucose on brachial artery function

To study the effect of transient high blood glucose level on the brachial artery FMD response, and to determine the reproducibility of the measurements and observed effect.

Peri-operative Accuracy and Safety of Real Time Continuous Glucose Monitoring System in cardiac surgical patients. A pilot study

The primary objective of this study is to investigate the peri-operative accuracy and safety of the RT-CGMS in cardiac surgical patients.The secondary objective is to identify and define possible factors interfering with reliable and adequate…

Metformin vs Control to prevent gestational diabetes mellitus (GDM) in women with a high risk for GDM, an open label randomized controlled trial. The Medico-GDM trial.

The primary objective is to compare metformin versus no intervention for incidence of GDM in women with a high risk for GDM. The main secondary objective is pregnancy outcome with Metformin, neonatal outcomes and neonatal complications.

Randomised Controlled Study to Evaluate the Impact of Novel Glucose Sensing Technology on Hypoglycaemia in Type 1 Diabetes.

The primary objective of this study is to demonstrate the impact on time in hypoglycaemia (number of hours per day of hypoglycaemic excursions < 3.9 mmol/L, 70 mg/dL) using the Abbott Sensor Based Glucose Monitoring System compared to Self…

A phase 4, monocenter, randomized, open label, comparator-controlled, parallel-group, mechanistic intervention trial to assess the effect of 8-week treatment with the glucagon-like peptide-1 receptor agonist lixisenatide versus insulin glulisine on renal physiology and biomarkers in insulin glargine-treated patients with type 2 diabetes mellitus

Main study:Primary objective: What are the long-term effects (i.e. after 8-week drug exposure) of the GLP-1RA versus a single dose prandial insulin onrenal hemodynamics (glomerular filtration rate/ effective renal plasma flow in basal insulin-…

Assessment of fracture healing by high-resolution peripheral quantitative computer tomography (HRpQCT) and bone strength analysis in standard care and after immediate administration of vitamin D.

Fracture healing groupPrimary outcome: to study the healing of distal radius fractures in terms of calculated bone strength based on the results of cortical and trabecular bone parameters using a novel HRpQCT technique (XtremeCT device, Scanco,…

Assessment of fracture healing by high-resolution peripheral quantitative computed tomography (HR-pQCT) and bone strength analysis in standard care and after immediate administration of calcium supplementation

The main objective is to compare the effect of immediate (or pre-existent) administration of daily calcium supplementation (1 Cacit bruisgranulaat *1000*: 1000 mg calcium) or two daily dosages of calcium + vitamin D (CaD® sachet 1000/880: 1000 mg…

TANGO-DM: Randomized trial of effective treatment according to new GDM criteria

To evaluate the effectiveness and cost-effectiveness of intensive GDM treatment as compared to routine maternity care in pregnant women with a discordant OGTT result between the new (2013) WHO criteria as compared to the old (1999) WHO criteria for…

The effect of intradialytic parenteral nutrition on nutritional status and quality of life in hemodialysis patients

The aim is to see whether intradialytic parenteral nutrition is an efective treatment against the loss of muscle mass

Virtual Monoenergetic Imaging of the Lower Extremities Using Dual-Energy CT Angiography in Patients with Diabetes Mellitus: A Randomized Controlled Trial

Several observational studies have been published evaluating DECTA for imaging of the lower legs, comparing this technique with conventional CTA. However, to the best of our knowledge, no randomised controlled trial has been conducted comparing both…

Combined effects of SGLT2 inhibition and GLP-1 receptor agonism on food intake, body weight and central satiety and reward circuits in obese T2DM patients

Primary objective:To investigate the separate and combined actions of the SGLT2 inhibitor dapagliflozin and GLP-1 receptor agonist exenatide on activity in central reward and satiety circuits in response to food related stimuli in obese patients…

Placebo-controlled double-blind randomized controlled trial investigating vitamin K supplementation on vascular calcification propensity in vitamin K deficient renal transplant recipients

To study the effect of vitamin K supplementation on calcification propensity and vitamin K status in RTRs with vitamin K deficiency.