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A Phase 2, Multicenter, Randomized, Active-Controlled, Parallel-Group, Dose-Finding and Safety Study of Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2)/Calcium Phosphate Matrix (CPM) in Subjects With Decreased Bone Mineral Density.

Onset of effect of systemic therapy to enhance bone density (eg, bisphosphonates) is not immediate and may not adequately protect subjects with decreased bone density from fracture.Bisphosphonate therapy will typically require 2 to 3 years of active…

The contribution of the sympathetic nervous system to the anabolic effect of estrogen on bone.

The objective is to study the effect of beta-agonist and beta-antagonist treatment on human bone remodeling.

The effect of high dose cholecalciferol orally on serum of vitamin D in elderly with osteoarthritis of the hip

To study the effect of high dose oral cholecalciferol suppletion on serum 25-OHD in elderly with osteoarthritis of the hip.

The effect of high dose cholecalciferol orally on serum of vitamin D in elderly with osteoarthritis of the hip

A pilot study the effect of high dose oral cholecalciferol suppletion on serum 25-OHD in elderly with osteoarthritis of the hip.

Assessment of fracture healing by high-resolution peripheral quantitative computer tomography (HRpQCT) and bone strength analysis in standard care and after immediate administration of vitamin D.

Fracture healing groupPrimary outcome: to study the healing of distal radius fractures in terms of calculated bone strength based on the results of cortical and trabecular bone parameters using a novel HRpQCT technique (XtremeCT device, Scanco,…

Assessment of fracture healing by high-resolution peripheral quantitative computed tomography (HR-pQCT) and bone strength analysis in standard care and after immediate administration of calcium supplementation

The main objective is to compare the effect of immediate (or pre-existent) administration of daily calcium supplementation (1 Cacit bruisgranulaat *1000*: 1000 mg calcium) or two daily dosages of calcium + vitamin D (CaD® sachet 1000/880: 1000 mg…

Treatment of Osteogenesis Imperfecta with Parathyroid hormone and Zoledronic acid

This study has been transitioned to CTIS with ID 2024-519705-36-00 check the CTIS register for the current data. The primary objective will be to investigate if a two-year course of TPTD followed by antiresorptive treatment with a single infusion of…

Active vitamin D for secondary hyperparathyroidism after bariatric surgery: a multicenter randomized controlled trial.

This study has been transitioned to CTIS with ID 2023-510312-40-00 check the CTIS register for the current data. Main objective- to investigate the effect of alfacalcidol on the treatment of secondary hyperparathyroidism in patients after RYGB…

The Vold-study: The effect of a 12-week self-composed vegan diet with or without concurrent resistance exercise on thigh muscle volume in older adults

Primary: To assess the effects of a 12-week self-composed vegan diet in comparison to an omnivorous diet on thigh muscle volume (TMV) in community-dwelling older adults. And to assess the effect of a 12-week self-composed vegan diet combined with…

Randomized placebo-controlled pilot study to determine the effect of probiotics on vitamin K status in renal transplant recipients

To investigate the effect of a daily sachet of probiotics for 12 weeks vs placebo on vitamin K status in renal transplant recipients.

The effect of an isocaloric, protein- and mineral-enriched ('postdischarge') formula on growth, body composition and bone mineralization of late preterm infants.;Follow-up: The effect of an isocaloric, protein- and mineral-enriched (*postdischarge*) formula on growth, body composition and neurocognitive development of late preterm infants at the corrected age of 2 years.

The main objective is to compare growth and body composition of late preterm infants at 6 months corrected age, fed either an isocaloric, protein- and mineral-enriched ('postdischarge') formula (PDF) or standard term formula (TF) between…