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Effect of transient high blood glucose on brachial artery function

To study the effect of transient high blood glucose level on the brachial artery FMD response, and to determine the reproducibility of the measurements and observed effect.

'Powerful together against diabetes'. A Social network intervention for type 2 diabetics with a low socioeconomic status.

The aim of this study is to evaluate the effect of the intervention *Powerful Together against Diabetes* on metabolic control, health related outcome measures, diabetes related behaviour, psycho-social outcome measures and intermediate outcome…

Is metabole regulation of diabetes type 2 patients starting with insuline therapy improved by self-management training? An investigation into decreasing psychological barriers and exploration of etnical barriers.

The objectives of the present study are twofold:1 screening patients with diabetes type 2 for psychological risk factors and2 studying the effect of a self-management training on metabolic regulation in patients starting with insuline therapy

The effect of implementation of a physical reactivation program on physical activity behaviour, quality of life and biological and psychosocial factors on type-2 diabetes patients.

The aim of this study is to determine whether a physical reactivation program is more effective in improving physical activity, quality of life, diabetes control and psychosocial well being than usual care.

Effect of simvastatin on myocardial triglyceride accumulation, cardiac function and al vessel wall thickness in patients with type 2 diabetes mellitus

To study the possible beneficial effect of simvastatin on accumulation of triglycerides in the myocardium of patients with DM2 and the effect on vessel wall thickness using magnetic resonance imaging and spectroscopy

A Double-Blind clinical trial of Benfotiamine Treatment in Diabetic Nephropathy

-To investigate whether a short-term treatment (3 months) with benfotiamine in diabetic nephropathy patients leads to a reduction in urinary excretion of β2-microglobulin and albumin.-To investigate whether short-term treatment (3 months) with…

A 12-Week, Double-Blind, Randomized, Placebo-Controlled Study in Type 2 Diabetes Mellitus Subjects to Evaluate the Efficacy, Safety and Tolerability of MTP Inhibitor JNJ-16269110

The primary objective of this study is to evaluate the effect of 12-week treatment with JNJ-16269110 on the glycated hemoglobin (HbA1c) concentration in subjects with T2DM.Additional objectives are to evaluate the effect of JNJ-16269110 on:1.…

Beyond expectations: the effectiveness of a theory driven intervention to achieve and sustain optimal self-management in patients with type-2 diabetes

The present study examines an extended version of this intervention that aims to address more challenging self-management goals once patients have mastered the skills necessary to achieve relatively small improvements in their self-management. The…

A randomized, double-blind trial comparing the efficacy and safety of a fixed combination of fenofibrate and metformin vs rosiglitazone in patients with type 2 diabetes mellitus and dyslipidemia

Primary objective : Under conditions of first-line drug treatment in antidiabetic drug naïve/drug free patients (no antidiabetic drug treatment in the last 6 months), with type 2 diabetes mellitus and dyslipidemia, to show that : - the efficacy of a…

A Multicenter, Randomized, Double-Blind Study to Determine the Efficacy and Safety of the Addition of SYR-322 25 mg versus Dose Titration from 30 mg to 45 mg of ACTOS® Pioglitazone HCl in Subjects with Type 2 Diabetes Mellitus Who Have Inadequate Control on a Combination of Metformin and 30 mg of Pioglitazone HCl Therapy

The objective of the study is to evaluate the efficacy of the addition of SYR-322 (25 mg) to subjects who are inadequately controlled on pioglitazone HCl (30 mg) and metformin (*1500 mg or MTD).

The effectiveness of plantar pressure assessment and monitoring in prescription footwear to reduce re-ulceration in diabetic patients: a randomised controlled trial

To what extent does the use of therapeutic footwear, which is prescribed and monitored using plantar pressure distribution assessment, result in a reduced plantar ulcer recurrence rate compared to the use of therapeutic footwear which is prescribed…

A phase 4, monocenter, randomized, open label, comparator-controlled, parallel-group, mechanistic intervention trial to assess the effect of 8-week treatment with the glucagon-like peptide-1 receptor agonist lixisenatide versus insulin glulisine on renal physiology and biomarkers in insulin glargine-treated patients with type 2 diabetes mellitus

Main study:Primary objective: What are the long-term effects (i.e. after 8-week drug exposure) of the GLP-1RA versus a single dose prandial insulin onrenal hemodynamics (glomerular filtration rate/ effective renal plasma flow in basal insulin-…

Effects of SUlodexide on Postprandial lipidmetabolism in patiEnts with diabetes mellitus type II; Reversing dyslipidemia

To investigate whether treatment with sulodexide can reverse postprandial dyslipidemia in patients with type 2 diabetes mellitus

A Phase 2, Double-Blind, Randomized, Placebo Controlled Study to Evaluate the Efficacy and Safety of ASP8232 as Add-On Therapy to Angiotensin Converting Enzyme inhibitor (ACEi) or Angiotensin Receptor Blocker (ARB) in Reducing Albuminuria in Patients with Type 2 Diabetes and Chronic Kidney Disease.

Primary Objective:To evaluate the efficacy of ASP8232 in reducing Urinary Albumin Creatinine Ratio (UACR) in subjects with Type 2 Diabetes Mellitus (T2DM) and Chronic Kidney Disease (CKD) at 12 weeks compared to placebo.Secundary Objectives:1. To…

A Phase 2 Placebo-Controlled, Double-Blind, Enriched Enrollment
Randomized Withdrawal Study to Evaluate the Efficacy and Safety of
BIIB074 (Vixotrigine) in Treating Pain Experienced by Subjects With
Confirmed Small Fibre Neuropathy That Is Idiopathic or Associated With
Diabetes Mellitus

The primary objective of this study is to evaluate the efficacy of BIIB074 in treating pain experienced by subjects with confirmed SFN that is idiopathic or associated with diabetes mellitus.Sub study objective:Corneal Confocal Microscopy (CCM) as a…

A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Study to Demonstrate the Effects of Sotagliflozin on Cardiovascular and Renal Events in Patients with Type 2 Diabetes, Cardiovascular Risk Factors and Moderately Impaired Renal Function

This study is designed to demonstrate the CV and renal effects of sotagliflozin in patients with T2D, high CV risk, and moderate renal impairment. One of the major objectives of this study is to fulfill the regulatory mandate that any new therapy…

Effects of a single denosumab injection on reduction of total contact cast treatment and consolidation of bonefractures caused by acute Charcotfoot in patients with diabetes mellitus (CHARCOT study)

This study has been transitioned to CTIS with ID 2024-518637-28-00 check the CTIS register for the current data. Does single subcutaneous injection with denosumab or placebo (NACL 0.9%) induces a shorter Total contact cast treatment duration and…

Randomised, double-blind (within dose groups), placebocontrolled and parallel group trial to investigate the effects of different doses of oral BI 685509 given over 20 weeks on UACR reduction in patients with diabetic kidney disease

The main objectives of the trial are to demonstrate the effectiveness of BI 685509 and to characterize the dose-response relationship for BI 685509 in patients with DKD by assessing 3 doses and placebo.

RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PARALLEL-GROUP STUDY TO ASSESS CARDIOVASCULAR OUTCOMES FOLLOWING TREATMENT WITH ERTUGLIFLOZIN (MK-8835/PF-04971729) IN SUBJECTS WITH TYPE 2 DIABETES MELLITUS AND ESTABLISHED VASCULAR DISEASE

Objective: To demonstrate the non-inferiority of ertugliflozin compared with anon-ertugliflozin comparator group on the time to first occurrence of any of thecomponents of the composite endpoint of cardiovascular death, non-fatal…

The Effect of Tirzepatide versus Dulaglutide on Major Adverse Cardiovascular Events in Patients with Type 2 Diabetes (SURPASS-CVOT)

This study has been transitioned to CTIS with ID 2023-507846-96-00 check the CTIS register for the current data. The main reason for conducting this study is to help in answering the following research question:• How tirzepatide compares to…