94 results
Primary ObjectivesTo assess, as primary economic outcome measure, cost-utility of a personalised multimodal orthotic treatment approach to reduce the risk of plantar foot ulcer recurrence in diabetes.And, as primary patient-related outcome measure,…
In this study we will investigate how safe the new compound Ent001 is and how well it is tolerated when it is used by healthy subjects.We also investigate how quickly and to what extent Ent001 is absorbed, transported, and eliminated from the body (…
In this project we intends to study the therapeutic potential of a personalized fibre mixture in individuals at high risk of developing T2DM, and aims to address the following key objectives: 1. To investigate whether a mixture of fermentable…
The overall objective of this study is to investigate both the efficacy as well as the safety of combined and prolonged use of S&SEs - as part of a healthy diet - in a population of overweight/obese adults and children.
To improve the healing rate and decrease wound surface area (WSA) of chronic diabetic foot ulcers using ESWT in combination with standard care. Furthermore, this study will investigate the long-term effects of ESWT on ulcer recurrence.
The primary objective is to demonstrate that semaglutide delays the progression of renal impairment and lowers the risk of renal and cardiovascular mortality compared to placebo, both added to standard-of-care, in subjects with type 2 diabetes and…
This study is designed to confirm the safety and efficacy of PLASOMA after CE marking:1. in a larger population,2. in a more diverse population, consisting also of non-diabetic wound types, and3. including long-term safety.and to determine the…
to investigate the effect of 14 days once daily oral Eubacterium hallii (E. hallii) treatment on postprandial glucose levels in relation to SCFA levels in feces in patients with type 2 diabetes treated with metformin.
Several observational studies have been published evaluating DECTA for imaging of the lower legs, comparing this technique with conventional CTA. However, to the best of our knowledge, no randomised controlled trial has been conducted comparing both…
The aim is to reduce SSI in PWT2D by implementing a proactive basal-bolus insulin regimen, compared to a widely used reactive sliding scale regimen. It is hypothesised that a proactive basal-bolus insulin regimen targeting glucose levels of 3.9-10…
The primary scientific aim of the PROMINENT study is to assess whether treatment with the selective peroxisome proliferator activated receptor modulator alpha (SPPARM-α), pemafibrate, will prevent myocardial infarction (MI), ischemic stroke,…
This study has been transitioned to CTIS with ID 2023-506981-30-00 check the CTIS register for the current data. Main objective:The primary objective is to demonstrate that combination therapy using finerenone and empagliflozin is superior in…
This study has been transitioned to CTIS with ID 2024-513304-33-00 check the CTIS register for the current data. The primary objective is to assess the effect of three doses of Diamyd compared to a placebo in terms of (1) beta cell function; and (2…
Primary Objective: to show a reduction in eGFR decline in patients treated with LCP tacrolimus compared to IR tacrolimus. Secondary objectives will include investigating the potential decline in other known side effects of calcineurin inhibitors i.e…
To investigate the effect of daily intake of 350 milligrams of magnesium citrate oral supplementation over a period of six months on calciprotein particle maturation time (T50) in serum, a measure of calcification propensity, and on vascular…
Phase 1 (0 - 24 Weeks) Objective:To study the effect of DMR on glycemic and mechanistic endpoints24 weeks post-procedure in subjects with T2D.Phase 2 (24 - 48 Weeks) Objective:To study the effect of DMR on glycemic endpoints for assessment…
To determine if dietary supplementation with seaweed improves glucose regulation in T2DM patients.
A relationship can be identified between HbA1c levels and self-management and quality of life. It appears better self-management skills result in a larger improvement of HbA1c levels, and the other way around, getting control over HbA1c levels is a…
The primary objective of this study is to investigate the effects of classical conditioning with intranasal insulin on endogenous insulin and glucose levels in diabetes type-2 patients and healthy controls. Additionally, we will examine the effects…
The main objective is to assess the efficacy of flexor tenotomy on the prevention of recurrence of toe ulcers in people with diabetes and a history of toe ulceration. Additionally, we aim to compare interphalangeal joints (IPJ) and metatarsal…