44 results
In this double blinded randomised controlled trial we aim to compare the effects of 4 grams of oral butyrate tablets once daily following autologous (own) faecal transplantation with post-RYBG donor faecal transplantation with placebo tablets, at…
to investigate whether microbial transplantation from either allogenic (healthy) or autologous (own) donor, administered through a small intestinal tube, has beneficial effects on immune status, betacell function c-peptide secretion upon mixed meal…
Primary objective: To assess the effects of hypercaloric overfeeding in humans on vascular and metabolic insulin sensitivity and moreover, to establish whether insulin resistance develops in the vasculature before it occurs in peripheral tissue…
The purpose of the study is to investigate wether long-term resveratrol supplementation (6 months) leads to improved insulin sensitivity (estimated by Matsuda Index) in people with overweight/obesity. In addition we will investigate effects of…
To assess whether bile acids reach the brain after a meal
PrimaryThe 3 months* effect of Vildagliptin on insulin synthesis and storage capacitySecondaryThe 3 months* effect of vildagliptin on- Glucose, insulin, C-peptide levels- Hormonal axes, most importantly GLP1 and GIP and Glucagon- Body weight, body…
To explore the inflammatory changes of a PCSK-9 inhibitor compared with placebo on postprandial lipemia and postprandial leukocyte activation, oxidative stress and endothelial function in men with type 2 diabetes mellitus.
Based on our hypothesis that orally administered GOS will be fermented into a SCFA pattern high in acetate and that this will lead to beneficial effects on human substrate and energy metabolism, we aim to address the following primary objective: To…
To investigate whether in obese subjects meal timing during a hypocaloric diet is related to the brain serotonergic system and insulin sensitivity as well as to food-motivated behavior.
In this follow-up study we would like to compare the effect of single versus multiple (2x) duodenenal tube infused allogenic versus autologous feces (as controls) on insulin resistance, cholesterol and (shortchain) free fatty acid metabolism in…
The primary objective of the study is to investigate whether carbohydrate co-ingestion augments the in vivo postprandial muscle protein synthetic response after protein ingestion and whether this response is differs between young and elderly…
In this single centre pilot intervention study, we will investigate the effects of short-term administration of the angiotensin-receptor antagonist losartan on insulin sensitivity (assessed by using the homeostasis model assessment of insulin…
The primary objective of the study is to investigate whether local insulin supplementation augments the in vivo postprandial muscle protein synthetic response after protein ingestion and whether this response is differs between young and elderly…
Objective: To study differences of (adipo) cytokine spectra in visceral and peripheral adipose tissue and to study the effect of caloric restriction on (adipo) cytokine production of these different fat tissues.
To provide insight in the physiological significance and underlying mechanisms involved in the relation between gut microbiota, energy balance and insulin sensitivity in overweight men with impaired glucose homeostasis
Our primary objective is the effect of taurine on morbidity and consequent mortality.
To investigate whether the in vivo postprandial muscle protein synthetic response is augmented when dietary nitrate ingestion precedes protein ingestion in elderly type 2 diabetics.
To investigate whether single dosis of fecal therapy by infusion of allogeneic (post bariatric surgery donor feces in the bowel) or autologous (own feces) have differential effect on lipid-metabolism-mediated insulin resistance.
To determine the effects of hypercaloric HFHS snacking in the morning or evening on insulin sensitivity and serotonin function in the diencephalon.
The major research objective is:Does a switch from a low-fat to a high-fat diet lead to a reduced hepatic and skeletal muscle insulin sensitivity due to an increase lipid accumulation in liver, skeletal muscle and heart? Secondary research…